Plot	L1D	Specific	Examples
	L1D279 (1.6)	L1T13 (39%): nanoparticles (2%), formulation (1%), carrier (1%), drug_delivery (1%), formulations (1%) L1T32 (5%): drug (12%), drugs (7%) L1T107 (4%): efficacy (16%), targeted (14%) L1T88 (4%): improve (9%), optimize (8%), improved (7%), improving (5%)	USE OF LH-RH AGONISTS AND ANTAGONISTS IN PROSTATE CANCER (1985) [+] USE OF LH-RH ANALOGS IN BREAST AND OVARIAN CANCER (1985) [+] USE OF HYPOTHALAMNIC HORMONES IN PANCREATIC CANCER (1985) [+] LIPOSOME ACTIVATED MACROPHAGES FOR THERAPY OF METASTASIS (1985) [+] DNR CONJUGATES FOR THERAPY OF DRUG RESISTANT LEUKEMIA (1986) [+] TOXICITY OF MEMBRANE ACTIVE CHEMOTHERAPEUTIC AGENT (1987) [+] SARCOPLASMIC RETICULUM: MEMBRANE TARGET OF ANTHRACYCLINE (1989) [+] PHARMOCOLOGY AND EFFICACY OF NOVEL TAXOL FORMULATIONS (1991) [+] A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY (1992) [+] LIPOPHILIC CAMPTOTHECINS FOR CANCER TREATMENT (1994) [+] TARGET SPECIFIC EMULSION FOR SYSTEMIC GENE DELIVERY (1997) [+] MECHANISMS OF ACTION OF HIGHLY EFFICACIOUS PGA-TAXOL (1997) [+] TUMOR TARGETED DRUG CARRIER WITH CONTROLLED DRUG RELEASE (1998) [+] Pluronic Block Copolymers in Drug Resistant Cancer (2001) [+] Design of Enzymes Mediating Anti-Cancer Drug Activation (2002) [+] Tumor-Specific Targeting of Folate-Derivatized Drugs (2002) [+] Cells Designed to Deliver Anticancer Drugs by Apoptosis (2003) [+] Cell-Penetrating Peptide Agents for Cancer Therapy (2003) [+] LONG-CIRCULATING TUMOR-SELECTIVE DNA DELIVERY SYSTEMS (2003) [+] Targeted Liposomal Doxorubicin Delivery to Leukemia (2003) [+] Targeted Proapoptotic Anticancer Drug Delivery System (2004) [+] Engineered intelligent micelle for tumor pH targeting (2004) [+] Polymer-Nucleotide Complexes with Cytotoxic Activity (2004) [+] Drug carrier of blood/tumor/brain permeability (2004) [+] Engineering Polymers For Gene Therapy of Head Cancer (2005) [+] Enhancing the efficacy of nucleoside analogs (2005) [+] NANOTHERAPEUTIC STRATEGY FOR MULTIDRUG RESISTANT TUMORS (2005) [+] Tumor drug delivery systems based on polymalic acid (2006) [+] MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS (2006) [+] Pharmacokinetic strategies to optimize IP chemotherapy (2006) [+] Tumor-targeted silencing of Bcl-2/Bcl-xL by the self-assembled siRNA-nanovectors (2006) [+] EGFR Targeted Nanoparticles to Overcome Paclitaxel Resistant Breast Cancer (2006) [+] Molecular Targeting of Drug Delivery System to Cancer (2006) [+] Cross-linked Polymer Micelles in Cancer Therapy (2006) [+] Targeting Nanoparticle DNA Delivery to Prostate Tumors (2007) [+] Tumor and PTK-Targeted Therapy by FUS1 and PTK inhibitor (2007) [+] Phospholipid Nanocarriers Improve Chemotherapy by Targeted Drug Delivery (2007) [+] Micellar Nanotherapeutics for Targeted Lung Cancer Therapy (2007) [+] TARGETING THE CASM ONCOGENE AS A NOVEL THERAPY FOR PANCREATIC CANCER (2007) [+] X-ray Targeted Therapeutic Genes within Nanoparticles (2007) [+] Phase I study of Clostridium novyi-NT spores in solid tumor cancer patients (2007) [+] LPD Nanoparticles in Anti-Cancer Therapy (2008) [+] Combination therapy using tumor-targeting synthetic dsRNA and gemcitabine (2008) [+] Targeted Lipopolyplexes for Oligonucleotide Delivery to AML (2008) [+] Targeted Therapeutics of LGL Leukemia utilizing Ceramide Nanoliposomes (2008) [+] DOUBLE-TARGETED MACROMOLECULAR THERAPEUTICS FOR THE TREATMENT OF PROSTATE CANCER (2008) [+] Targeted Nanoparticle DNA Therapy for Ovarian Cancer (2008) [+] Development of JS-K as an anti-leukemic agent (2008) [+] Surface-modified pharmaceutical nanocarriers for subcellular targeting (2008) [+] Novel cancer therapy by EGFR targeted transfection of synthetic dsRNA (2008) [+] Treatment of Chemotherapy-Resistant Human Ovarian Cancer by Administration of CPE (2008) [+] Systemic Non-Viral Gene Therapy for Cancer (2008) [+] Anaerobic Bacteria as Oncopathic Agents for Pancreatic Cancer (2009) [+] Molecular mechanism of antiangiogenic properties of gold nanoparticle (2009) [+] Overcoming Drug Resistance to Nucleoside Analogs by Tumor-Targeted Active Nanofor (2009) [+] Ident. of Structural Features of HK Polyplexes for Imprv. siRNA Deliv. to Tumors (2009) [+] Aptamer-siRNA Chimeras Targeting HER2-Positive Breast Cancers (2009) [+] Targeted and traceable delivery of siRNA with nanoparticle-amphipol (2009) [+] Intelligent Polymeric Nanogel Technology Overcoming Drug Resistance in Ovarian Ca (2009) [+] Novel nanoparticles for siRNA delivery (2010) [+] Drug Resistance In Cancer Therapy (2010) [+] Targeting aberrant epigenetics by nanomedicine (2010) [+] Tumor Targeted Corroles for Detection and Intervention (2010) [+] Enzyme-instructed self-assembly for anticancer nanomedicine (2010) [+] Synergistically Acting Targeted Therapeutics for Melanoma (2010) [+] Multifunctional Nanotherapeutics for Cancer Treatment and Imaging (2010) [+] Targeted Chemoprevention for Melanoma (2010) [+] Multifunctional nanoparticles for targeting aberrant tumorigenic pathways (2010) [+] Size-tunable cancer nanotherapeutics (2010) [+] Synergistic chemo-siRNA combination therapy (2011) [+] CpG-siRNA Conjugates to Target Acute Myeloid Leukemia (2011) [+] CPE Peptide-Based Nanoparticles for the Diagnosis and Therapy of Chemotherapy Res (2011) [+] Multifunctional PEG Hydrogel Nano/Microparticles for Targeted Treatment of NSCLC (2011) [+] Nanocrystals for the Treatment of Multidrug Resistance in Cancer (2011) [+] Discovery of Novel Thiazole Analogs for Treating Malignant Melanoma (2011) [+] Tumor Penetrating Peptides for Cancer Targeting (2011) [+] Hybrid nanotechnology to target metastatic advanced prostate cancer (2012) [+] High Density Lipoprotein Nanoparticles for siRNA Delivery (2012) [+] Internalizing human antibody-targeted nanosized siRNA therapeutics (2012) [+] SIGMA-2/PEPTIDOMIMETIC CONJUGATES TARGET APOPTOSIS IN PANCREATIC CANCER (2012) [+] The role of fibroblasts in the activities of tissue penetrating peptides (2012) [+] Targeting Stromal Collagen in Pancreatic Cancer (2013) [+] Phosphatidylserine Targeted Tumor Cell Lytic Peptoids (2013) [+] An osteolytic stimuli-responsive nanotherapeutic system for bone metastases (2013) [+] Novel Nanoparticle Therapy for Pancreatic Cancer (2013) [+] Targeted Combination Therapy for Breast Cancer (2014) [+] A Nanotechnology Platform for Suicide Gene Therapy of Recurring Ovarian Cancer (2015) [+] Liposomal Doxorubicin and Pluronic Combination for Cancer Therapy (2015) [+] Targeted Radiation Therapy for Pancreatic Cancer (2015) [+] Targeted- and timed-releasing nanotherapeutics against leukemia stem cells (2015) [+] Novel pRNA Nanoparticle Delivery as Directed Therapy for Colorectal Cancer Metastasis (2015) [+] Tumor priming sequences combined with novel nanoparticle drug carriers for enhanced therapeutic efficacy in pancreatic cancer: a tripartite USA/Northern Ireland/Republic of Ireland consortium (2015) [+] Targeting the vascularity for delivery of inhibitors of metastasis in ovarian cancer (2015) [+] Painted erythrocyte carriers for therapy of acute myeloid leukemia (2016) [+] Development of Targeted Nanotechnology Platform for Pancreatic Cancer (2016) [+] Aerosol Delivery of Topotecan for Personalized Lung Cancer Therapy (2016) [+] Glutaminase Inhibitor Drug Discovery and Nanoparticle-Based Delivery for Pancreatic Cancer Therapy (2016) [+] Tumor-Targeted Chemo-Immunotherapy for Osteosarcoma Metastasis (2016) [+] Tumor vasculature-targeted nanotherapeutics for DNA damage response (2016) [+] Systemic RNA Delivery to Tumors (2016) [+] Combination Therapy of OvCa with Oligonucleotides and Photodynamic Therapy (2016) [+] Targeted Nanotherapy for Pancreatic Cancer (2016) [+] Nanoparticle-mediated treatment for bone metastasis (2016) [+] Inhaled Delivery of Vidaza for Targeted Epigenetic Lung Cancer Therapy (2016) [+] Lipid-dendrimer micellar nanocarriers for siRNA/drug co-delivery in MDR cancer (2016) [+] Immunostimulatory Nanocarrier for Breast Cancer Immunochemotherapy (2017) [+] Catch and Release Immunotoxins: CAR-Bombs for Cancer (2017) [+] Synthetic Lethal Targeting of Growth Factor Receptors (2017) [+] Secondary Chemoprevention of Oral Cancer by Locally Delivered Agents (2017) [+] Reprogramming Tumor Microenvironment by Nanoparticle (2017) [+] Improving the in vivo delivery and antitumor efficacy of antisense drugs (2017) [+] Novel Enediyne-Based Antibody-Drug Conjugates for Cancers (2017) [+] Development of novel protein-based therapeutics for lung cancer (2018) [+] NextGen RNAi Delivery to Breast Tumors for Selective mTORC2 Blockade (2018) [+] Self-assembled multifunctional aptamer-complex biomaterial for precision medicine (2018) [+] Nanoscale Coordination Polymers Co-deliver Chemotherapeutics and siRNAs for Efficacious Treatment of Resistant Ovarian Cancer (2018) [+] Nanotherapeutics for Synergistic Targeting of Myc in Prostate Cancer (2018) [+] TUMOR SPECIFIC DELIVERY OF VERTICILLIN A OVERCOMES EPIGENETIC SILENCING RESPONSIBLE FOR DRUG RESISTANCE (2018) [+] Tumor-targeted inhibitors of stearoyl-CoA desaturase for the treatment of cancer. (2018) [+] Cyclic Peptide Nanoparticles Based Dual-drug Delivery to Treat Prostate Cancer (2018) [+] Impact of Fn14-targeted Nanoparticles for Triple-Negative Breast Cancer (2018) [+] miR-155 targeted therapeutics for precision medicine in lung cancer (2018) [+] P-selectin-Mediated Targeting of PI3K Nanomedicines to the Tumor Microenvironment (2018) [+] Mechanism of Intratumoral Transport of Particulate Drugs (2018) [+] Elucidation and therapeutic exploitation of PAK mediated radioresistance (2018) [+] A Targeted Nanomedicine Prototype Against Enzalutamide-resistant Prostate Cancer (2018) [+] Tumor caveolae-targeted systemic therapy of breast cancer with antibody drug conjugates (2019) [+] An improved IL-24 gene-based therapeutic for cancer (2019) [+] Endothelial Cell-Targeted Amatoxin Conjugates for Effective Therapy of Breast Cancer (2019) [+] Copper-depleting nanotheranostics for treating triple negative breast cancer (2019) [+] Self-immolative prodrug/miRNA nanoparticle combinations for cancer treatment (2019) [+] Bionanotechnology approach for treatment of lung cancer (2019) [+]
	L1D341 (1.5)	L1T127 (35%): snps (3%), gwas (2%) L1T157 (8%): genetic (11%), variants (11%), genome-wide (8%) L1T141 (5%): identified (13%), identify (11%), disease (10%), identifying (9%), identification (9%) L1T112 (5%): discover (5%), genomics (5%), datasets (4%), top (3%)	STATISTICAL METHODS FOR GENETIC EPIDEMIOLOGY OF CANCER (1992) [+] MAPPING PROSTATE CANCER SUSCEPTIBILITY LOCI (1994) [+] FAMILIAL CLUSTERING OF CANCER IN UTAH (1995) [+] GENETIC ANALYSIS OF HEREDITARY PROSTATE CANCER FAMILIES (1999) [+] MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER (1999) [+] GENETIC EPIDEMIOLOGY OF PROSTATE CANCER AGGRESSIVENESS (2000) [+] MOLECULAR EPIDEMIOLOGIC STUDY OF BREAST CANCER (2000) [+] GENETICS OF VULNERABILITY TO NICOTINE ADDICTION (2000) [+] Genetic Epidermiology of Melanoma (2001) [+] Pathways from genotype and environment to melanoma (2001) [+] Mapping and Cloning Prostate Cancer Predisposition Loci (2001) [+] Molecular and Genetic Analysis of Lung Cancer Survival (2002) [+] Statistical Methods for Genetic Epidemiology (2002) [+] Pancreatic Cancer Genetic Epidemiology Consortium (2002) [+] Genetic Susceptibility to Non-Hodgkins Lymphoma (2003) [+] IDENTIFICATION OF MELANOMA PREDISPOSITION LOCI (2003) [+] Genetics of Prostate Cancer Risk &Agressiveness (2003) [+] Gene Copy Number Changes and Breast Cancer Survival (2004) [+] Interaction of PTEN and CDKN1B in Pca susceptibility (2004) [+] Identification of Melanoma Susceptibility Gene at 1p22 (2004) [+] Genetic studies of mammographic density (2005) [+] Elucidating the somatic genetics of prostate cancer (2005) [+] QTL mapping for genes regulating apoptosis capacity (2006) [+] Genetic Epidemiology of Glioma International Consortium (2006) [+] EphB2 as a Prostate Cancer tumor Suppressor and Risk Factor in African Americans (2006) [+] A Genome-Wide Association Study of Non-Hodgkin Lymphoma (2006) [+] Statistical Methods for Gene Environment Interactions In Lung Cancer (2007) [+] Focused Genomic Dissection of the Prostate Cancer Risk Variant on Chromosome 8q24 (2007) [+] Phenotype-based approach to find gene interactions underlying breast cancer risk (2007) [+] Mapping Genes for Mammographic Breast Density (2007) [+] Database of Functional SNPs in Cancer-Related Environmentally Responsive Genes (2007) [+] Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology (2007) [+] Fine mapping and characterization of the 8q24 prostate cancer risk locus (2007) [+] COMMON AND RARE SEQUENCE VARIANTS IN BREAST CANCER RISK (2007) [+] High Density Association Analysis of Lung Cancer (2007) [+] Genetic epidemiology of cell division regulation in breast cancer (2007) [+] The IGF Signaling Pathway and Breast Cancer Risk (2007) [+] Prostate Cancer in a Black Population (2007) [+] Haplotype-Based Genome Screen for Ovarian Cancer Loci (2007) [+] Cross-species network approach to predict epistatic cancer susceptibility genes (2008) [+] Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast &Colo (2008) [+] New Familial Colon Cancer Gene Discovery Via Combined Linkage and SNP Association (2008) [+] Confirmation of SNPs Associated with Aggressive PCa in a GWA Study (2008) [+] Inflammation Genes and Lung Cancer Risk (2008) [+] Identifying Genes for Mammographic Breast Density (2008) [+] The Genetic Basis of Neuroblastoma Tumorigenesis (2008) [+] Genetic Factors for Breast Cancer- A genome Wide Study (2008) [+] Fanconi Defects in Pancreatic Cancer Oncogenesis (2008) [+] Cell Cycle/Apoptosis Gene Variants and Breast Cancer Risk (2008) [+] Whole Genome Scan for Modifier Genes in Colorectal Cancer (2008) [+] Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS) (2009) [+] Genetic Susceptibility for Lung Cancer in African Americans (2009) [+] Replication of Association Signals Identified in Ulcerative Colitis GWAS (2009) [+] Replication Study of Breast Cancer Susceptibility Genes in Blacks (2009) [+] Fine Mapping and Replication of a Genome-Wide Association Scan for SLE in Hispani (2009) [+] PD GWAS Consortium (2009) [+] Genome-wide Copy Number Variation and Breast Cancer Risk (2009) [+] Genome-wide scan for genetic variants associated with early-onset prostate cancer (2009) [+] Genome Wide Association Study of Head and Neck Cancer (2009) [+] Genome-Wide Association Study of Endometrial Cancer (2009) [+] Genome-Wide Study to Identify SNPs and CNPs Associated with Radiation Injury (2009) [+] Genetics Variants in the Genome Predisposing to Aggressive PCa (2009) [+] The role of germline and somatic DNA changes at 8q24 in PCa risk (2009) [+] Whole Genome Association Study of Mammographic Density (2009) [+] Genome-Wide Association Study of Radiation Exposure and Bilateral Breast Cancer (2009) [+] MIcroRNA: A Novel Genetic Modifier for Breast Cancer Predisposition (2009) [+] Functional Analysis of Genome Wide Associations in Colorectal Cancer (2010) [+] A genomewide study of lung cancer in never smokers (2010) [+] The Mitochondrial Genome and Ovarian Cancer Risk (2010) [+] Pooling and expansion of Chronic Lymphocytic Leukemia GWA data (2010) [+] Genome-wide association study of breast cancer in the African Diaspora (2010) [+] Genetic Predictors of AML Treatment Response (2010) [+] International Case Control Study of Malignant Glioma (2010) [+] GENETIC EPIDEMIOLOGY OF CHRONIC LYMPHOCYTIC LEUKEMIA (2010) [+] Identifying Ovarian Cancer Susceptibility Alleles using Genome-Wide Scan Data (2010) [+] Genomic Approaches to Defining Inherited Basis of Childhood Cancer (2010) [+] Genomic Enhancers at 8q24 and Prostate Cancer (2010) [+] Discovery of New Genes for Inherited Predisposition to Breast Cancer by Exome Seq (2011) [+] A comprehensive approach to breast cancer susceptibility across the risk spectrum (2011) [+] Breast and prostate cancer risk SNPs regulate FoxA1 and nuclear receptor activity (2011) [+] Validation and Fine-Scale Mapping of Pancreatic Cancer Susceptibility Loci (2011) [+] Genetic determinants of gene expression phenotypes in aggressive prostate cancer (2011) [+] COPY NUMBER VARIANTS AND EARLY-ONSET BREAST CANCER (2011) [+] Molecular and Genetic Analysis of Neuroendocrine Tumor Risk and Survival (2011) [+] Functional Significance of Prostate Cancer risk-SNPs (2011) [+] Consortium Study to Identify Breast Cancer Susceptibility Loci (2011) [+] Resequencing and Functional Studies to Identify Causal Gene Variants of Lymphoma (2011) [+] Genome Sequencing to identify novel genetic factors for breast cancer risk (2012) [+] Genome-wide association study of breast cancer in high-risk women (2012) [+] Shared Genomic Segment Analysis and Tumor Subtyping in High-Risk BrCa Pedigrees (2012) [+] Genome-wide sequencing of prostate cancer in men of African ancestry (2012) [+] Whole Genome Sequencing to Discover Familial Myeloma Risk Genes (2012) [+] Massively Parallel Sequencing for Familial Colon Cancer Genes (2012) [+] Genetic Etiology of Cancer Drug Response (2012) [+] CANCER SUSCEPTIBILITY VARIANT DISCOVERY IN HIGH THROUGHPUT SEQUENCING DATA (2013) [+] Genetic Susceptibility and Risk Model for Pancreatic Cancer (2013) [+] COMPLETE VARIANT PROFILING OF ALL KNOWN BREAST CANCER GENES (2013) [+] MicroRNA & Breast Cancer: Functional Characterization in a Population-Based Study (2013) [+] The contribution of rare alleles to ovarian cancer in the population (2013) [+] Identifying Prognostic Markers and Therapeutic Targets for Serous Ovarian Cancer (2013) [+] Discovery of Risk Loci and Genomics of Pancreatic Cancer through Exome Sequencing (2014) [+] Colorectal cancer risk loci: GWAS, fine-mapping, and functional analysis (2014) [+] Next generation sequencing to identify novel colorectal cancer genes (2014) [+] Identifying and validating novel susceptibility genes for breast cancer (2014) [+] Germline and Tumor Genomic Analyses of Breast Cancer in Latinas (2014) [+] High-throughput sequencing to identify novel melanoma susceptibility genes (2015) [+] Methods for Integrating Functional Data into Complex Disease Genetic Analyses (2015) [+] Breast Cancer Risk Enhancers (2015) [+] Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors (2015) [+] Genetic Susceptibility to Pediatric Glioma inIndividuals and Diverse populations (2015) [+] Identifying causal variants and genes underlying breast cancer risk loci (2016) [+] Functional Characterization of Glioma GWAS Variants (2016) [+] Genome-wide Pleiotropy Scan across Multiple Cancers (2016) [+] Genetic Epidemiology of non-Hodgkin Lymphoma (2016) [+] Epidemiology and biology of lncRNAs in ovarian cancer (2016) [+] Breast Cancer genetic study in African-ancestry populations (2016) [+] Using functional genomics to inform gene environment interactions for colorectal cancer (2016) [+] The Genetic Basis of Aggressive Prostate Cancer: The Role of Rare Variation (2016) [+] Functional Effects of Ovarian Cancer Risk Variants (2017) [+] (PQ3) UNDERSTANDING THE INTERACTIONS BETWEEN GERMLINE AND SOMATIC ALTERATIONS in the PATHOGENESIS OF GLIOMAS (2018) [+] Genomic and Transcriptomic Analysis of Breast and Ovarian Cancers (2018) [+] Theory and methods for mediation and interaction (2018) [+] Genetic Risk Prediction of Breast Cancer for African Americans (2018) [+] Transcriptome-wide association study to identify susceptibility genes for colorectal cancer (2018) [+] Genetic studies of homologous recombination deficiency in hispanic gastric cancer (2018) [+] Discovery, Biology and Risk of Inherited Variants in Glioma (2018) [+] Genetic mechanisms underlying sexual dimorphism in cancer and response to therapy (2019) [+] Characterizing germline and somatic alterations by glioma subtypes and clinical outcome (2019) [+] PQ3 Cutaneous squamous cell carcinoma: Integrating germline and somatic alterations that underlie tumor progression (2019) [+] Integration of germline and tumor genomes in CLL (2019) [+] Eliminating variants of uncertain significance in BRCA1, BRCA2 and beyond (2019) [+] Integrating genomic and transcriptomic data to identify breast cancer susceptibility genes (2019) [+] Transcriptome-wide association studies and genetic risk prediction for breast cancer integrating RNA splicing and gene expression from multiple tissues (2019) [+]
	L1D335 (1.4)	L1T13 (31%): drug_delivery (3%), nanoparticles (3%), nanoparticle (2%) L1T203 (4%): delivery (25%), deliver (16%) L1T32 (4%): drug (14%), drugs (9%), agent (8%), agents (7%) L1T107 (4%): efficacy (14%), targeted (13%) L1T91 (3%): brain_tumors (8%), brain (6%), bbb (6%), brain_tumor (6%), gbm (4%) L1T14 (3%): imaging (8%), mri (6%), molecular_imaging (5%) L1T88 (3%): optimize (7%), optimized (6%), limited (5%), local (4%), improved (4%)	PDT IN THE TREATMENT OF PANCREATIC CANCER (1992) [+] TRANSPLANTATION AND HEPATOXINS FOR LIVER CANCER (1993) [+] ACOUSTICALLY ACTIVATED MICELLAR DRUG DELIVERY (1999) [+] BRAIN THERAPY USING ULTRASOUND MEDIATED DRUG DELIVERY (1999) [+] NOVEL HUNTER KILLER PEPTIDES FOR CANCER THERAPY (2000) [+] TOPOTECAN BY INTRACEREBRAL CLYSIS FOR BRAIN TUMORS (2002) [+] Interstitial Drug Delivery to Thermoablated Liver Tumors (2002) [+] Intracerebral Infusion of Radiolabeled Specific Antibody (2002) [+] Controlled Drug Delivery to Colon Tumors Via Ultrasound (2004) [+] Metallofullerene Nanoplatform for Imaging &Treatment (2005) [+] Multifunctional Nanoparticles in Diagnosis and Therapy (2005) [+] Nanotechnology Platform for Pediatric Brain Cancer Image (2005) [+] Functional Polymer Matrixes for Site-Specific, Image Guided Drug Delivery (2006) [+] Nanovectors For Brain Tumor Diagnosis And Treatment (2007) [+] Integrin avb3 targeted drug design, delivery, and imaging (2007) [+] Radiolabeled RGD Peptides for Breast Cancer Imaging and Therapy (2007) [+] An integrated system for tumor detection and targeted drug therapy of cancer (2007) [+] Enhanced Intraarterial Delivery of Chemotherapeutic Drugs to the Brain (2008) [+] Development of Targeted Anticancer Drugs (2008) [+] Nanoimmunoliposome-Complexed SPIO: Tumor-Specific Detection of Early Lung Cancer (2008) [+] Dendritic nanomedicine for cancer imaging and treatment (2008) [+] Targeted liposomal radiotherapy of malignant mesothelioma (2008) [+] Chlorotoxin as a Targeting Agent for Cancer Therapies (2008) [+] Development of Molecularly Targeted Imaging Agents for Early Detection of PDAC (2008) [+] Image-guided Prodrug and siRNA Targeting of Cancer (2009) [+] Mucus penetrating nanoparticles for early stage cervical cancer (2009) [+] Local Radionuclide Delivery to Solid Tumors by Injectible Biopolymer (2009) [+] Sensitizer Delivery for Focused Hyperthermia Cancer Treatment (2009) [+] Tumor exosomes as agents of genetic change (2009) [+] PSMA-based Cancer Imaging Agents (2009) [+] Molecular Target for Liver Cancer Diagnosis and Therapy (2009) [+] Development of a gold nanoparticles based targeted delivery system (2009) [+] Ultrasonic assessment of therapeutic response (2009) [+] Molecular Combinatorial Therapy of Glioblastoma Multiforme (2010) [+] Targeted Therapy to Receptors for LH-RH in Prostate Cancer (2010) [+] Nanoparticle-Directed Photothermal Ablation of Primary Brain Tumors guided by Mag (2010) [+] Molecularly guided multimodal theranostics for breast cancer (2010) [+] 'Exvading'Invasive Pediatric Brain Tumors (2010) [+] An Integrated Nano-Cell Delivery Platform of Theranostics for Lung Cancers (2010) [+] Ovarian Cancer PDT: Multi-intracellular targeting and Image-guided dosimetry (2011) [+] Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBM (2011) [+] See, Reach, Treat Tumor-Optimized Transarterial Chemoembolization Drug Delivery (2011) [+] Quantitative MRI-Guided Nanoembolization for Liver Cancer (2011) [+] Personalizing Nanoparticle Therapy (2011) [+] Integrated Image-Guided Targeted Therapy for Refractory Ovarian Cancer (2011) [+] Highly Paramagnetic, Biodegradable Nanoclusters for Imaging Prostate Cancer (2011) [+] Radiation response modulation of tumors using biocongjugated gold nanoparticles (2011) [+] MRI Capable Receptor Targeted Drug Delivery for Pancreatic Cancer (2011) [+] Image-guided combination therapy: noninvasive assessment of delivery and response (2011) [+] Ultrasound enhanced penetration for treatment of pancreatic cancer (2011) [+] Targeted Therapy of Triple Negative Breast Cancer Using Theranostic Nanoparticles (2011) [+] Flexible, Conformal, Polymeric Films for Lung Resection Margins (2011) [+] CED of Nanoparticles Loading with Novel Agents for Improved Treatment of Gliomas (2011) [+] Optical Imaging of Chemotherapy for Brain Tumors (2011) [+] A Surface Activable Nanoemulsion platform for Breast Cancer Diagnosis and Therapy (2011) [+] Brain Tumor-Penetrating Nanoparticle Delivery with MR-Guided Focused Ultrasound (2012) [+] Renally Excreted Multimodal Core-Shell Silica Nanoparticles as Tumor-Selective Ra (2012) [+] CHRONIC CONVECTION ENHANCED DELIVERY (CED) OF TOPOTECAN FOR GLIOBLASTOMA (2012) [+] TSPO Ligands for Cancer Imaging (2012) [+] A Suite of Tumor Targeting Peptides for Personalized Therapy of Lung Cancer (2012) [+] Using EMP2 for Image Guided Drug Delivery for Breast Cancer (2012) [+] Improving therapy of glioblastoma multiforme by enhancing therapeutic drug delive (2012) [+] Heterocellular 3D ovarian tumor arrays for imaging and mechanistic combinations (2012) [+] Tumor-targeted Polymersomes to image and Treat Ovarian Cancer (2013) [+] Theranostic nanoparticles for the treatment of RAI refractory thyroid cancer (2013) [+] Developing targeted therapy with prostate cancer specific nanomedicine (2013) [+] Nanoparticle formulations of DNA repair inhibitors to improve chemoradiotherapy (2013) [+] Multifunctional nanoparticles to improve treatment of human glioblastoma (2013) [+] Biomaterials for treatment of head and neck cancer (2013) [+] Detection of micrometastasis using a dual-ligand nanoparticle (2013) [+] Radiation and Receptor Targeted RadioTheranostic Nanoparticles for Glioblastoma (2014) [+] MR Guided Focused Ultrasound Controlled Stem Cell Therapy for Brain Tumor (2014) [+] A nanosystem for tumor treatment and imaging (2014) [+] PET Imaging-guided Personalized Therapy in Pancreatic Cancer (2014) [+] (PQD5) imaging systemic tissue injuries induced by anticancer drugs (2014) [+] In vivo derived in silico model for DDS optimization (2014) [+] CRC-specific near-IR agents for tumor imaging (2014) [+] Preventing tumor relapse with biomaterial-supported lymphocyte implants (2014) [+] Optimized ultrasound-enhanced immunotherapy (2015) [+] Stem Cell/Nanoparticle Constructs for Targeted Ovarian Cancer Therapy (2015) [+] Image-guided radiation-induced permeability (IGRIP) for IGDD (2015) [+] MR-HIFU induced drug delivery for pancreatic cancer treatment (2015) [+] Endovascular Chemofiltration: Optimizing Removal of Chemotherapeutics and Nanoparticles from the Blood to Reduce Toxicity (2015) [+] Convertible MRI contrast signaling delivery and release of anti-glioma nano-drug (2015) [+] Early Phase Clinical Trials in Imaging and Image-Guided Interventions (2015) [+] Stimuli-responsive crosslinked theranostics against advanced prostate cancer (2015) [+] Differential MRI imaging for brain tumor metastases diagnosis and treatment monitoring (2015) [+] MRI-Monitored Delivery of Sorafenib-Eluting Microspheres to Liver Tumors (2015) [+] Nanodelivery to enhance the imaging and therapy of breast cancer (2015) [+] Bioluminecence-activated photodynamic therapy of breast cancer (2015) [+] Enhancing Liver Cancer Treatment With Image-Guided Magnetic Hyperthermia (2015) [+] Image-guided EMT inhibition for treating metastatic breast cancer (2015) [+] Diagnosis and longitudinal monitoring of metastatic prostate cancer through molecular MR imaging (2016) [+] avb6-directed molecular imaging and therapy (2016) [+] Image-guided ultrasound therapy and drug delivery in pancreatic cancer (2016) [+] Treatment of glioma with nanocombretastatin with MRI monitoring (2016) [+] Simultaneous Thermal and Osmotic Stresses in Tumor Ablation: Imaging and Biology (2016) [+] Targeted therapy of peritoneal carcinomatosis using theranostic nanoparticles (2016) [+] Nanoparticle-Based Triple Modality Imaging and Photothermal Therapy of Brain Tumors (2016) [+] Glial tumor image-guided surgery and treatment (2016) [+] Organic nanoparticles for dual MRI-guided therapeutic selection and ovarian cancer drug delivery (2017) [+] High-frequency Irreversible Electroporation (H-FIRE) combinatorial GBM treatment (2017) [+] Development of PET imaging biomarkers to predict enhanced glioblastoma radiotherapy by a novel H-NOX oxygen carrier (2017) [+] Antivascular ultrasound therapy of primary liver neoplasia (2017) [+] Stroma targeted theranostic nanoparticles for pancreatic cancer (2017) [+] Targeted Molecular Imaging of Plectin-1; Bench to bedside and back again (2017) [+] Image Guided Delivery and Evaluation of Low? Density Lipoprotein-Docosahexaenoic acid Nanoparticles for the Management of Hepatocellular Carcinoma (2017) [+] HER2-pretargeting image-guided therapy of breast cancer (2017) [+] Active Delivery of Platinum Nanoimmunoconjugates to Improve Breast Cancer Therapy (2017) [+] MR-Guided Focused Ultrasound Combined with Immunotherapy to Treat Malignant Brain Tumors (2017) [+] A Novel Molecular Imaging Agent for Surgical Resection of Invasive Brain Tumors (2017) [+] Smart and self-reporting clinical nano carriers for drug delivery (2017) [+] First in human study with 18F-avb6-targeting peptide (2017) [+] Precision nanotherapeutics for cancer treatment (2017) [+] Tumor-targeted nanoparticle-based delivery system for imaging and treatment of cancer (2017) [+] A multiplexed approach to improve tumoral targeting and chemotherapeutic treatment (2018) [+] Catheter-Directed Image-Guided Delivery of Cytostatic and Cytotoxic Combination Therapy to Liver Tumors (2018) [+] PET nanoreporter image-guided breast cancer therapy (2018) [+] Treating Tumoral Hypoxia via Ultrasound-Guided Oxygen Release for Improving Radiation Therapy (2018) [+] Nanodelivery platform for antibody drugs targeting NHL (2018) [+] Spatiotemporal delivery of synergistic drug combinations to kidney cancer (2018) [+] Engineering knotted peptide therapeutics for pediatric brain tumor patients (2018) [+] The Impact of FUS-Mediated Brain Cancer Therapy on BBB Transport, Cytokines, and Immunocyte Trafficking (2018) [+] Novel Receptor-Targeting Peptides for Melanoma Therapy (2018) [+] Clinical Development of Rhenium Nanoliposomes (RNL186) for Glioblastoma (2019) [+] Biomaterial Drones for Image-Guided Drug Delivery during radiotherapy (2019) [+] Localized delivery of glycosaminoclycan ethers for the treatment of radiation-induced proctitis (2019) [+] SUPERHYDROPHOBIC DRUG LOADED BUTTRESSES FOR PREVENTION OF LUNG TUMOR RECURRENCE (2019) [+] Anti-vascular and cytotoxic nanoparticle formulations for ovarian cancer therapy (2019) [+] OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA (2019) [+] Development of Novel Acoustic Clusters for Improving Combinatorial Neuroblastoma Therapy (2019) [+]
	L1D358 (1.4)	L1T112 (14%): computational (5%), networks (4%), high-throughput (3%) L1T99 (10%): drivers (4%), driver (3%), driver_genes (2%), genome_editing (2%), driver_events (2%) L1T157 (9%): mutations (9%), genetic (9%), genomic (6%), somatic_mutations (5%), somatic (5%) L1T50 (6%): approaches (3%), many (3%), cancer (3%), our (2%), we (2%) L1T33 (5%): systematic (4%), challenge (4%), integrate (4%), integrated (2%), systematically (2%) L1T36 (4%): tools (8%), enable (8%), validation (7%), robust (6%), platform (5%) L1T160 (3%): functional (18%), complex (12%), understanding (9%)	PATHOLOGY OF TUMOR GROWTH (1997) [+] MAPPING NETWORKS OF GENE INTERACTIONS IN YEAST (1997) [+] IDENTIFYING GENOME CHANGES IN CANCER DEVELOPMENT (1998) [+] Microsphere Array for Lung Cancer Mutation Scanning (2001) [+] COMPUTATIONAL &LABORATORY STUDY OF P16/INK4 MUTATIONS (2002) [+] Oncogenic Gene Regulatory Networks (2005) [+] A Functional Census of p53 Cancer and Suppressor Mutants (2005) [+] Genetic analysis of mouse chromosome 11 (2006) [+] Combinatorial Genomics in Cancer (2006) [+] Coordinating Cell Killing by Communication: Biological Control and Cancer Therapy (2006) [+] Predicting and testing gene function in the human cell division cycle (2007) [+] The Molecular Basis for Bortezomib Activity (2007) [+] Gene expression programs of lactic acidosis in human cancers (2007) [+] An integrative approach to cancer gene discovery in hepatocellular carcinoma (2007) [+] Global characterization of lysine acetylation in cancer by a proteomics approach (2008) [+] Identification and characterization of driver gene(s) in recurrent lung cancer am (2008) [+] A genomic survey of allele-specific selection in tumor amplicons (2008) [+] A Genome Wide RNAi Vulnerability Map for Myeloma (2008) [+] Gene Networks Essential to Colon Cancer Phenotype (2008) [+] Comparative functional genomics for lung cancer gene discovery (2008) [+] High-throughput analysis of pancreatic cancer mutations (2009) [+] MicroRNAs and other non-coding RNAs in Colorectal Metastasis (2009) [+] Defining genetic pathways of plasma-cell neoplasia (2010) [+] Retrotransposon instability in glioblastoma multiforme (2011) [+] Mechanistic Elaboration of Fragility in the Cancer Cell Mitotic Spindle (2011) [+] Enabling NF-kB Signal Transduction Studies in Primary Multiple Myeloma Cells (2012) [+] Predicting Transcriptional and Epigenetic Networks in Cancer from Sequencing Data (2012) [+] Discovery and Characterization of Methylation Markers (2012) [+] Integrative Cancer Genomics: Drivers, Pathways and Drugs (2012) [+] Epigenetic Drivers of Cancer (PQ 10) (2012) [+] Integrative Analysis to Identify Therapeutic Targets for Lung Cancer (2013) [+] Molecular characterization of myeloma and related asymptomatic precursor states (2014) [+] Identification and modeling of driver genetic modules in glioblastoma (2014) [+] Systematic Functional Characterization of RNA Editing in Endometrial Cancer (2014) [+] CHARACTERIZATION OF RECURRENT ADJACENT GENE TRANSLOCATIONS IN BREAST CANCER (2014) [+] Analysis of Intratumoral Crosstalk in Clonal Populations of OvarianTumor Cells (2014) [+] Characterization of RNA-Chromatin Interactome by RNA-DNA Ligation and Sequencing (2014) [+] (PQB5) Reconstruction of Evolutionary Networks using Cross-Sectional Genomic Data (2014) [+] Role of LMO1 in Neuroblastoma Initiation and Maintenance (2015) [+] The impact of chromosome 17p lesions on leukemogeneis and therapy response (2015) [+] Integrative interpretation of the organismal consequences of non-coding variation (2015) [+] Computational Model of Autophagy-Mediated Survival in Chemoresistant Lung Cancer (2015) [+] Genomic Evolution of Breast Cancer (2015) [+] A network platform to connect drug response and prognosis phenotypes for cancers (2016) [+] Roles for Intracellular pH Dynamics in Cancer (2016) [+] Genomic Architecture of LGL Leukemia (2016) [+] Interaction-based computational methods for analyzing cancer genomes (2016) [+] Framing Therapeutic Opportunities in Tumor-Activated Gametogenic Programs (2016) [+] Mutator Phenotype in Colon Cancer (2016) [+] Connecting Genomic Alterations in Liposarcomas with Drug Responses and Identification of New Therapeutic Approaches (2016) [+] Regulation of mRNA splicing by intronic genetic variants (2016) [+] Structural Variation in Neuroblastoma (2016) [+] A Quantitative Multiplexed Platform for the Pharmacogenomic Analysis of Lung Cancer (2016) [+] Determinants of pancreatic cancer and malignant melanoma phenotypes in CDKN2A hereditary kindreds (2016) [+] (PQ8) Genetically faithful murine models for studying disease progression in chronic lymphocytic leukemia (2017) [+] Understanding Long Tail Driver Mutations in Cancer (2017) [+] Elucidating Cancer Risk in BRCA2 and RAD51 Variants (2017) [+] Multigenic copy number alterations (2017) [+] Visualization and Epigenomic Characterization of Early Intestinal Tumorigenesis in Mice (2017) [+] Using microfluidic single cell culture to characterize cancer cell asymmetric division (2017) [+] Database and Tools for Functional Inference and Mechanistic Insight into Somatic Cancer Mutations (2017) [+] Dissecting tumor metabolic heterogeneity in vivo (2017) [+] Genetic Analysis of Breast Cancer Progression in Mice Using Inducible Transposition (2017) [+] Quantitative Computational Methods to Accurately Measure Tumor Heterogeneity in Solid Tumors to Inform Development of Evolution-based Treatment Strategies (2018) [+] A plasticity and reprogramming paradigm for therapy resistance at the single cell level (2018) [+] Systematic mapping of genetic vulnerabilities in head and neck cancer (2018) [+] Rewiring of regulatory networks in breast cancer by transcription factor isoforms (2018) [+] Tools for annotating mutations in the 3D cancer genome (2018) [+] (PQ4) Novel tools for in vivo study of genetic interactions in cancer progression (2018) [+] PROLIFERATION-QUIESCENCE CONTROL IN SINGLE CELLS: INTEGRATION OF MITOGEN, NUTRIENT, AND STRESS SIGNALING (2018) [+] Multiscale systems biology modeling to exploit tumor-stromal metabolic crosstalk in colorectal cancer (2018) [+] (PQ4) Quantitative and multiplexed analysis of gene function in cancer in vivo (2018) [+] Integrating bioinformatics into multiscale models for hepatocellular carcinoma (2018) [+] Discovery of Somatic Noncoding Variants that Serve as Drivers in Pediatric Cancers (2018) [+] Natural Products with Selective Cytoxicity to Non Small Cell Lung Cancer (2018) [+] A GENETIC INTERACTION MAP OF THE HUMAN NUCLEUS (2018) [+] DNA Methylation and gene expression variations influence pituitary adenoma hormonal function and invasive growth (2018) [+] Computational Methods for Identifying Non-coding Cancer Drivers (2018) [+] Engineered ECM platforms to analyze progression in high grade serous ovarian cancer (2018) [+] Unbiased identification of spliceosome vulnerabilities across cancer (2018) [+] Reducing Cancer Transcriptional Heterogeneity through Regulation of Chromatin Structure (2018) [+] High-throughput Epigenomic Mapping of Regulatory Elements in Ovarian Cancer at Basepair Resolution (2018) [+] Reverse Sensitivity Analysis for Identifying Predictive Proteomics Signatures of Cancer (2019) [+] Multiplexed functional analysis of BRCA1and BARD1 missense variants in DNA repair (2019) [+] Single-cell characterization of tumor and microenvironment co-evolution in Peripheral T-cell Lymphomas (2019) [+] Unraveling mechanisms of tumor suppression in lung cancer (2019) [+] Multiscale Resolution and Deep Network Approaches for Deconvolving Different Cell Types in Bulk Tumor using Single-cell Sequencing Data (scDEC) (2019) [+] Mechanistic insights into Variants of Uncertain Significance (VUS) using novel EGFR variants as a paradigm (2019) [+] An integrated approach to melanoma metastasis and therapy resistance: effects of age-related changes in the ECM and the biomechanics of the skin (2019) [+] Cancer under pressure: Mechanisms of adaptation to compressive stress (2019) [+] Decoding the fundamental mechanisms of tumor emergence and evolution (2019) [+] Characterizing noncoding GWAS variants in acute lymphoblastic leukemia treatment outcome (2019) [+] In Vivo Base Editing for Precision Oncology Models (2019) [+] Understanding the full spectrum of epigenetic vulnerability in cancer through the delineation of DNA methylation function in gene 3' end (2019) [+] Spatial epigenomics: A new framework for overcoming mechanical heterogeneity in solid tumors (2019) [+] Comparative analysis between patient-derived models of pancreatic ductal adenocarcinomas and matched tumor specimens (2019) [+]
	L1D301 (1.4)	L1T13 (25%): nanoparticles (3%), nanotechnology (2%), imaging_agents (2%) L1T100 (7%): optical (5%), fluorescence (4%), microscopy (4%), fluorescent (3%), optical_imaging (3%) L1T66 (5%): develop (10%) L1T36 (4%): technology (13%), platform (8%), enable (7%) L1T72 (4%): binding (6%), assembly (6%), bind (5%), libraries (4%), structure (4%) L1T162 (3%): peptides (18%), molecules (14%), vivo (13%) L1T32 (3%): drugs (10%), agents (6%), drug (6%)	NEW APPROACHES TO ANALYSIS OF BIOPOLYMERS (1986) [+] CONTROLLED RELEASE OF LIPOSOMAL CONTENTS IN MACROPHAGES (1987) [+] CONTRAST AGENTS AND MODELS OF TISSUE BEHAVIOR FOR MRI (1987) [+] DEVELOPMENT OF A 191-OS:191M-IR RADIONUCLIDE GENERATOR (1987) [+] CLEAVABLE SURFACTANT-BASED VESICLES FOR CANCER TREATMENT (1987) [+] MR RECEPTOR IMAGING (1991) [+] TISSUE TARGETING WITH PHAGE LIBRARIES (1997) [+] IN VIVO IMAGING OF TUMOR CELL ENDOCYTOSIS (1998) [+] MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION (1999) [+] ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY (2000) [+] MR IMAGING OF GENE EXPRESSION (2000) [+] HIGH EFFICIENCY LYMPHOCYTE LABELING FOR IN VIVO TRACKING (2000) [+] THERMALLY SENSITIVE DRUG DELIVERY SYSTEM FOR TUMORS (2000) [+] DEVELOPMENT OF Q-DOTS AS BIOLOGICAL PROBES (2000) [+] PORPHYRAZINE TUMOR CONTRAST AGENTS (2001) [+] Targeted Molecular Probes for Tumor Imaging (2002) [+] Engineered Antibody EGFR Antagonist Cancer Therapeutics (2002) [+] c-src inhibitors from novel encoded chemical libraries (2003) [+] Multifunctional Nanoparticles for Intracellular Delivery (2003) [+] Novel optical probes for in vivo imaging (2003) [+] Ultrasound Imaging and Local Drug Delivery in Tumors (2004) [+] Biomolecular Analysis using Liquid Crystals (2004) [+] Optical Probes &Methods for Imaging Integrin Expression (2004) [+] Detecting cancer early with targeted nano-probes (2005) [+] Hybrid Nanoparticles in Imaging and Therapy of Prostate* (2005) [+] DNA-linked dendrimer nanoparticle systems for diagnosis (2005) [+] Photodestruction of Ovarian Cancer: ErbB3 Targeted (2005) [+] Near-Infrared Fluorescence Nanoparticles for Imaging (2005) [+] Nanotechnology Platform for Targeting Solid Tumors (2005) [+] Diagnostic &targeting reagents for lung cancer (2005) [+] Mechanisms of ultrasound mediated intracellular drug and gene delivery (2005) [+] PARACEST agents for molecular imaging of cancer by MRI (2005) [+] USING VIRAL NANOPARTICLES TO TARGET CANCER (2005) [+] Novel Cancer Nanotechnology Platforms for Photodynamics (2005) [+] Application of Nanotechnology in Photodynamic Therapy (2005) [+] Micelle surface engineering for active targeting by acidic tumor extracellular pH (2006) [+] Label-Free Screening Using Photonic Crystal Sensors for the Apoptotic Pathway (2006) [+] Engineering Multifunctional Nanoparticles (2006) [+] Catalysis and Inhibition of Gelatinases (2006) [+] NIR-Emissive Polymersomal Markers for Molecula-Level Detection of Metastasis (2006) [+] CT Monitoring of Angiogenesis (2007) [+] Targeting Pancreatic Cancer (2007) [+] Drug Delivery Carriers Targeted to Breast Tumor by Fusion Phage Proteins (2007) [+] Nanovectors for Characterization and Destruction of Breast Tumor Vasculature (2007) [+] Fate and Effects of Nanoparticles: Relationship to Physicochemical Properties (2007) [+] Lipid Nanoparticle Mediated Inhibition and Detection of Matrix Metalloproteinases (2008) [+] Carbon Nanotubes as Multi-functional Spectroscopic Markers and Delivery Agents fo (2008) [+] pHLIP Nanotechnology Platform for Cancer Imaging and Therapy (2008) [+] Metal nanoparticle-mediated diagnosis, targeting, and treatment of cancer (2008) [+] Multifunctional Photosensitizers for Image-guided PDT of Brain Tumors (2008) [+] Ultra-Sensitive MR Probes for Molecular Diagnosis of Lung Cancer (2008) [+] Nanotubes in tumor imaging and therapy (2008) [+] Sensitive and multiplexed analysis of cancer biomarkers with QD barcodes (2008) [+] Use of New Bacterial Enzymes to Improve Nitro-Prodrug Cancer Therapy (2008) [+] Development of an Assay for the Early Detection of Ovarian Cancer (2009) [+] Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery (2009) [+] Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor (2009) [+] A Technological Platform for the Identification of Serine Proteases in Cancer (2009) [+] NMR and NIR Detection of Phospholipase Activity In Vivo (2009) [+] Adaptable Polymer Micelles for Tumor Targeting (2010) [+] Identifying antigens bound by novel scFvs targeting all subtypes of mesothelioma (2010) [+] Nanovalve Platform: Targeted, Controlled, Release of Anticancer Drugs (2010) [+] Layer-by-layer nanocarriers for highly efficient solubilization of insoluble drug (2010) [+] Design of Therapeutic Peptide-Based Nanoparticles (2010) [+] GOLD NANOCAGES AS A NEW CLASS OF THERAPEUTIC AGENTS FOR PHOTOTHERMAL CANCER TREAT (2010) [+] Biodegradable Plasmonic Nanoparticles for Cancer Imaging and Therapy (2010) [+] Microfluidic Platform for Preparation of Biomolecule Based Nuclear Imaging Probes (2011) [+] Activatable MR Imaging Probes (2011) [+] Quantitative analysis of pharmacological mechanism by intravital imaging (2011) [+] Characterization of Erbb Receptors in Nanoparticles (2011) [+] Intracellular Trafficking of Antisense and siRNA Oligonucleotides in Cancer Cells (2011) [+] Targeting aggressive prostate cancer with novel theranostic nanomedicine (2011) [+] Novel Single Domain Antibodies with Multivalency and Multispecificity (2012) [+] Multifunctional Nanoparticles for Image-Guided Vaccine Delivery in Cancer (2012) [+] (PQD5) Development of in Vitro Vascularized Microtumors for Drug Screening (2013) [+] Supramolecular Assemblies for Detecting Biomarkers in Complex Mixtures (2013) [+] Acyclic Cucurbit n uril Molecular Containers for Drug Solubilization and Delivery (2013) [+] Spatially-resolved proteomic mapping of living cells (2013) [+] Quantitative Imaging of Cancer Drug Resistance via Radioluminescence Microarrays (2014) [+] Biosensor Assay to Screen for Signaling Pathway Inhibition in Cancer (2014) [+] Chemical Probes for In Vivo Fibrin Imaging (2015) [+] Development of a New Generation Micro-CT imaging for Functional and Molecular Imaging of Cancer (2015) [+] Quantitative assessment of the role of collagen alterations in ovarian cancer (2016) [+] Phospholipase-activated theranostics for PDT of breast cancer (2016) [+] Multiplexed analysis of exosomes in cancer nano therapy (2016) [+] Targeting Lymphatic Vessels for Ligand Directed Imaging (2017) [+] Role of tumor heterogeneity on receptor engagement (2017) [+] Structure and function of Transient Receptor Potential channels (2017) [+] Rapid Protease Profiling with a Multiplex Electronic Method for Detection of Metastatic Triple-Negative Breast Cancer (2017) [+] (7) Novel imaging devices for measurement and control of tumor microenvironments (2017) [+] Implantable microdevices with integrated optical imaging for high-throughput in situ tumor response and drug sensitivity measurement (2018) [+] Imaging tumor microenvironment by Optical Fiber-Tethered Simultaneous Lifetime-resolved Autofluorescence-Multiharmonic (OFT-SLAM) microscopy (2019) [+] A Fluorescence-Based High-Throughput Platform for Glycotyping the Hematopoietic Cell Lineage (2019) [+] Modular approach for the delivery of antibodies into the cytoplasm of cells (2019) [+]
	L1D364 (1.4)	L1T112 (14%): computational (4%), high-throughput (3%), computational_tools (3%), profiling (3%), networks (3%) L1T80 (12%): software (5%) L1T10 (11%): precision_medicine (2%), microfluidic (2%), throughput (2%), untargeted (1%), multiplexed (1%) L1T33 (9%): challenges (4%), integration (3%), challenge (3%), integrate (3%), integrated (3%) L1T36 (6%): tools (11%), platform (10%), enable (8%), technology (7%), technologies (6%)	NEW APPROACH FOR RAPID MAPPING OF PROTEIN VARIATIONS (1997) [+] SINGLE MOLECULE IMMUNOASSAY AND DNA SCREENING (1998) [+] MEASUREMENT OF KINASE ACTIVITIES IN SINGLE TUMOR CELLS (1998) [+] PARALLEL AND HIGH THROUGHPUT MICROSAMPLE PROCESSING (1999) [+] RAT GENOME DATABASE (1999) [+] Electronic Access to Mouse Tumor Data (2002) [+] Interdisciplinary Tumor Complexity Modeling (2003) [+] p53 target Genes in Apoptosis (2004) [+] Nanotechnology Linking Biomarkers with Cancer Behavior (2004) [+] Genetic Network Inference with Combinational Phenotypes (2005) [+] High Throughput PCR-Based Gene Expression Screening (2005) [+] Integrated system for cancer biomarker detection (2005) [+] COMPUTATIONAL TOOLS FOR CANCER PROTEOMICS (2006) [+] Analysis and Statistical Validation of Proteomic Datasets (2006) [+] A Platform for Pattern-Based Proteomic Biomarker Discovery-R01 (2006) [+] New Proteomic Algorithms to Identify Mutant or Modified Proteins (2006) [+] Enhancement of MS signal processing toward improved cancer biomarker discovery (2006) [+] PICquant-An integrated platform for biomarker discovery (2006) [+] Knowledge-based Gene Expression Analysis for Biomedical and Cancer Research (2006) [+] Quantitative Methods for Spectral and Image Data in Proteomics Research (2006) [+] Differential metabolic network analysis of tumor progression (2007) [+] Chemical Probes for Metabolic Pathway Discovery in Human Disease (2007) [+] Statistical Inference on Chemotherapy Effects from Flow Cytometry Data (2008) [+] Integrated Biochip Sensors for Detection of Cancer (2008) [+] High-content Image Analysis and Modeling for RANigenome-wide Screening (2008) [+] Application of MAGNet Tools to Gene Regulatory Networks in Cancer (2008) [+] Software &Hardware Inference Engines for Automated Determination of Primary Cell (2008) [+] Bayesian models for cancer prognosis by integrating diverse types of data (2008) [+] Signaling Network Dynamics in Metastatic Prostate Cancer (2009) [+] Functional consequences of cancer mutations (2009) [+] Providing Peptide Atlas Based Services through the caGRID infrastructure (2009) [+] Prediction of Pathologic Complete Response by Gene Expression Profiling in Esopha (2010) [+] Analysis of LC-MS data to identify peptide and glycan biomarkers for hepatocellul (2010) [+] Predicting Adjuvant Chemotherapy Response in Lung Cancer (2010) [+] Individualizing cancer predictions via selective voting in convex-hull ensembles (2010) [+] Tools for Linking and Mining image and Genomic Data in Non-Small Cell Lung Cancer (2011) [+] High Content Representation and Association of 3D Cell Culture Models (2011) [+] Statistical Methods for Normalizing Microarrays in Cancer Biomarker Studies (2011) [+] Molecular Signatures to Characterize the Oncogenic State of Individual Tumors (2011) [+] Multiplexed Detection of Cell Free DNA Biomarkers for Cancer (2011) [+] A New Model of Peptide Fragmentation for Improved Protein Identification and Targ (2011) [+] Development of quantitative multiplex RNA in situ hybridization (2011) [+] Integrative methods for high-dimensional genomics data (2011) [+] Validation of a single cell multiplexed in-situ biomarker analysis platform for p (2012) [+] A next-generation Integrative Genomics Viewer for biomedical and cancer research. (2012) [+] Identifying the cellular hierarchy and drug response of AML using cytometric data (2012) [+] A Predictive Prognostic Model for Glioblastoma Multiforme (2012) [+] Rare Cancer Genetics Registry (2012) [+] Analytical Approaches to Massive Data Computation with Applications to Genomics (2013) [+] BIGDATA: DA: Interpreting massive genomic data sets via summarization (2013) [+] Delineating Heterogeneous Structural Complexity in Cancer Genomes (2013) [+] Genetic circuits for high-throughput, multi-sensory, live cell microRNA prof (2013) [+] Biomarkers for predicting response to Hsp90 therapy (2013) [+] BIGDATA: Mid-Scale DCM: DA: ESCE: Discovering Molecular Processes (2013) [+] Man's Best Friend for Driver-Passenger Distinction (2014) [+] Tracing Cell Lineages (2014) [+] VERSA: An Integrated, Multi-Endpoint Platform for Circulating Tumor Cell Analysis (2014) [+] A scalable image-based approach for profiling and annotating very large compound (2014) [+] Multiparameter single-cell genomics platform for personalized treatment of cancer (2014) [+] VIRUS DISCOVERY AND CHARACTERIZATION IN LARGE-SCALE CANCER SEQUENCING DATA (2014) [+] Power calculation and design issues in next-generation sequencing (2015) [+] Exploiting the immune response to detect pathogen-induced cancers (2015) [+] Molecular and Therapeutic Basis of Morphometric Aberrations in Brain Tumors (2015) [+] A Label-Free, Point-of-Care Platform to Diagnose Acute Promyelocytic Leukemia (2015) [+] Hardwiring Mechanism into Predicting Cancer Phenotypes by Computational Learning (2016) [+] RNA circuits for cell state determination in mammalian cells in vitro and in vivo (2016) [+] Analysis of cancer cell metabolism in diverse environmental conditions (2016) [+] Graph-based Bayesian analysis of Genomics and Proteomics Data (2016) [+] Multi-parametric 4-D Imaging Biomarkers for Neoadjuvant Treatment Response (2016) [+] Highly multiplexed and mutation-sensitive quantitative PCR for cancer diagnostics (2016) [+] (PQ3) A functional genomic approach to identification and interpretation of germline-tumor genetic interactions (2018) [+] Cross-Platform and Graphical Software Tool for Adaptive LC/MS and GC/MS Metabolomics Data Preprocessing (2018) [+] Addressing Sparsity in Metabolomics Data Analysis (2018) [+] MULTIPLEX CHEMICAL TAGS FOR HIGH-THROUGHPUT GLYCAN AND GLYCOPEPTIDE QUANTITATION AND CHARACTERIZATION (2018) [+] Molecular and clinical evaluation of the glioma patient experience to anticipate modern outcomes and guide patient care (2018) [+] An Academic-Industry Partnership to Advance Functional Genomics for Personalized Oncology. (2018) [+] Clinical platform for high-throughput analyses of extracellular vesicles (2018) [+] Deep learning based antibody design using high-throughput affinity testing of synthetic sequences (2018) [+] Enhancing the dog as a model for human cancers: from genome sequence towards clinical trials. (2018) [+] Transforming family dogs into a powerful and accessible model for human cancer (2018) [+] Mummichog 3, aligning mass spectrometry data to biological networks (2018) [+] Tools for Leveraging High-Resolution MS Detection of Stable Isotope Enrichments to Upgrade the Information Content of Metabolomics Datasets (2018) [+] Bioinformatics Technology to Characterize Tumor Infiltrating Immune Repertoires (2018) [+] Dissecting the complexity of metastasis with mathematical models and quantitative experiments with in zebrafish (2018) [+] Computational Tools for Analysis and Visualization of Quality Control Issues in Metabolomic Data (2018) [+] Daily Quantification of Cancer-Associated Exosomal miRNA in Patient Blood by Photonic Crystal-Enhanced Quantum Dot Emission (2018) [+] Methods for Analyzing Cancer Somatic Mutation Data (2018) [+] Early Detection through Novel OCEAN Technology - Ovarian Cancer Exosomal Analysis with Nanoplasmonics (2018) [+] A Comprehensive Platform for High-Throughput Profiling of the Human Reference Metabolome (2018) [+] Chromatin mobility in response to DNA damage (2018) [+] Informatics Tools for Quantitative Digital Pathology Profiling and Integrated Prognostic Modeling (2018) [+] Methods and Tools for Integrative Functional Enrichment Analysis of Metabolomics Data (2018) [+] Synthesizing Image-derived Heterogeneity with Genomic measurements for Assessing Disease Aggressiveness in Lower Grade Gliomas (2018) [+] Novel Computation Methods for the Analysis of Cell-Free DNA Sequence Data (2019) [+] Clinicopathologic and Genetic Profiling through Machine Learning and Natural Language Processing for Precision Lung Cancer Management (2019) [+] Reactome IDG portal: Pathway-based analysis and visualization of understudied human proteins (2019) [+] A data analytics framework for mining the dark kinome (2019) [+] Clinical translation of a NexGen platform for quantifying protein networks in human biospecimens (2019) [+] Integrating microbial glycan arrays with genomic sequences to study host microbe interactions (2019) [+] The Federated Tumor Segmentation (FeTS) platform: An intuitive tool facilitating secure multi-institutional collaboration (2019) [+] Microfabricated instrumentation to measure sphingolipid signaling in human acute myeloid leukemia (2019) [+] PDB MANAGEMENT BY THE RESEARCH COLLABORATORY FOR STRUCTURAL BIOINFORMATICS (2019) [+] Informatics resources for liquid biopsy research (2019) [+] Nano-Engineered Lab-on-a-Chip for Assessing HuR-Regulated Exosomes for Cancer Monitoring and Targeted Therapy (2019) [+] Rigorous and reproducible mutational analysis of the urinary exosomal DNA (2019) [+] Tool for Predicting Glycosaminoglycan Recognition of Proteins (2019) [+] Illuminating the Druggable Genome by Knowledge Graphs (2019) [+] Experimental-Computational Synthesis of Altered Immune Signaling in Breast Cancer (2019) [+] Exploiting public metagenomic data to uncover cancer-microbiome relationships (2019) [+] Distributed Learning of Deep Learning Models for Cancer Research (2019) [+] Lymph Node Quantification System for Multisite Clinical Trials (2019) [+] Computational pathology software for integrative cancer research with three-dimensional digital slides (2019) [+]
	L1D333 (1.5)	L1T187 (27%): disparities (3%), ethnic (3%), whites (2%), aa (2%), african_american (2%) L1T127 (14%): african_ancestry (2%), genetic_risk_factors (2%), snps (2%), environmental_factors (2%), ancestral (2%) L1T57 (7%): risk_factors (3%), japanese (3%), case-control_study (2%), blacks (2%), epidemiology (2%) L1T148 (4%): incidence (19%), risk (14%)	RACIAL DIFFERENCS IN PROSTATE CANCER--AN AUTOPSY STUDY (1991) [+] P53 BREAST CANCER MUTATIONS IN HIGH AND LOW RISK GROUPS (1992) [+] PREMALIGNANT LESIONS OF THE PROSTATE--AGE AND RACE STUDY (1995) [+] MALIGNANT COMPLICATIONS OF CHRONIC HEPATITIS C VIRUS (1999) [+] POLYMORPHISMS IN PROSTATE CANCER CARCINOGENESIS (2000) [+] Molecular epidemiology of Barretts esophagus and cancer (2002) [+] Molecular Genetics of Colon Cancer in Blacks and Whites (2002) [+] Molecular Epidemiology of Fatal Prostate Cancer (2003) [+] Multi-Center Study of Pancreatic Cancer Etiology (2004) [+] Ethnic/Racial Minorities in the Colon CFR (2004) [+] Admixture Mapping for Breast Cancer in Latinas (2007) [+] Molecular Epidemiology and Lung Cancer: A Nested Case-Control Study (2008) [+] Genetic determinants associated with pemetrexed response and toxicity (2009) [+] Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta (2009) [+] DNA Methylation: a Mechanism for Aggressive Breast Cancer in African-American Wom (2010) [+] Genome Wide Admixture Scan for Multiple Myeloma in African Americans (2010) [+] Growth Factors and Lethal Prostate Cancer Signature (2010) [+] Epidemiology of Ovarian Cancer in African-American Women (2010) [+] Inflammation Pathways and COPD in the Development of Lung Cancer (2011) [+] Obesogenic environment: impact on breast, colorectal, and prostate cancer risk (2011) [+] Adding Hispanics to Ongoing GWAS in Colorectal Cancer (2011) [+] Genome-Wide Association Study of Childhood Leukemia by Hispanic Status (2011) [+] Genetic Risk Factors for Ewing's Sarcoma (2012) [+] Helicobacter pylori blood biomarker for gastric cancer risk in East Asia (2013) [+] Genome-Wide Association Study (GWAS) in Hepatocellular Carcinoma (HCC) (2015) [+] Helicobacter pylori protein-specific antibodies and colorectal cancer risk (2015) [+] Molecular Classification of High Grade Endometrial Cancers: Extending TCGA Findings to a Diverse Population (2016) [+] Characterizing Molecular Subtypes of Ovarian Cancer in African-American Women (2016) [+] Lung cancer in never smokers: incidence, risk factors, and molecular characteristics in Asian American, Native Hawaiian and Pacific Islander females (2016) [+] Oral Microbiome and Lung Cancer Risk (2016) [+] Circadian Disruption and Risk of Prostate Cancer in a Multiethnic Cohort (2016) [+] Breast Cancer In Blacks: Impact of Genomics, Healthcare Use and Lifestyle on Outcomes (BRIGHT) (2017) [+] Exploring factors related to racial disparities in ovarian cancer incidence and survival: the OCWAA consortium (2017) [+] Investigating the cause of racial/ethnic disparity in pancreatic cancer incidence (2017) [+] Molecular pathoepidemiology of contralateral breast cancer (2017) [+] Impact of germline variants on racial and ethnic differences in somatic mutation frequency (2018) [+] Understanding the Determinants of Racial/Ethnic Disparities in Liver Cancer and Chronic Liver Disease in Understudied and High-Risk Populations (2018) [+] Genomics of HCC in the Hispanic population of Texas (2018) [+] Colonic responses to vitamin D and aspirin in African- and European-Americans (2018) [+] Somatic Mutations and Their Etiological Determinants for Breast Cancer in African American Women (2019) [+] Relationships between parity, breastfeeding and ER- breast cancer in African American women: Elucidating the biologic underpinnings at the molecular and cellular level. (2019) [+] Understanding the Multilevel Drivers of Liver Cancer Disparities (2019) [+] Biological determinants of colorectal cancer outcomes in Latinos of diverse ancestral origins (2019) [+] Investigating genetic ancestry influences on oral cavity and laryngeal cancer survival disparities (2019) [+] Molecular Epidemiology of Langerhans Cell Histiocytosis: Evaluating the Impact of SMAD6 and Genetic Ancestry on Disease Risk (2019) [+]
	L1D354 (1.3)	L1T99 (12%): patient-derived (3%), patient_samples (3%), predictive_biomarkers (2%), targeted_therapies (2%), cutting-edge (2%) L1T10 (9%): single-cell (3%) L1T15 (6%): therapies (9%) L1T50 (5%): our (2%), we (2%), most (2%), approaches (1%), primary (1%) L1T112 (4%): evolutionary (7%), profiling (5%), computational (4%), genomics (4%), infer (4%) L1T33 (4%): guide (4%), accelerate (3%), comprehensive (3%), challenges (3%), an_innovative (2%) L1T188 (4%): heterogeneity (12%), single_cell (10%), predict (8%), predictive (7%), predicting (7%) L1T157 (4%): genomic (20%) L1T129 (3%): subtypes (7%), specimens (5%), prognosis (5%), prognostic (4%), expression_profiles (4%)	THERAPY AND BIOLOGICAL CORRELATES OF SOFT-TISSUE SARCOMA (1995) [+] Ethnicity-based proteomic biomarkers in breast cancer (2002) [+] Characterization of Leiomyosarcoma and GIST by Genomics (2003) [+] GENOMIC ANALYSIS OF MEDULLOBLASTOMAS (2004) [+] Molecular Approaches to Early Detection of Lung Cancer (2005) [+] Signal Transduction Pathways in Glioblastoma (2005) [+] Translating Prostate Cancer Gene Expression Subtypes (2005) [+] Molecular Characterization of Leiomyosarcoma and GIST (2005) [+] Individualized Treatment of Pancreatic Cancer (2006) [+] Resistance and Response Mechanisms to Prostate Cancer Therapy (2006) [+] Validation of RNA and DNA Biomarkers of Prognosis in Chronic Lymphocytic Leukemia (2006) [+] Molecular Predictive Testing in Ocular Melanoma (2006) [+] Tailoring New Drugs in Pancreatic Cancer (2007) [+] Somatic genetic predictors of response to therapy in metastatic melanoma (2007) [+] Genomic Analysis of Tumor Context Vulnerabilities in Human Metastatic Melanoma (2007) [+] Epigenetic regulation of temozolomide responsiveness in glioblastoma (2008) [+] Human Breast Cancer Stem Cell Surrogates (2008) [+] Conserved Biology of Tumor and Microenvironment in Breast Cancer Progression (2008) [+] Dissecting Mechanisms of Metastasis Through Comparative Systems Genetics (2008) [+] Optimal Predictors of Response to Trastuzumab (2009) [+] Identifying Inborn Genetic Susceptibility to Development of Cancer Metastasis (2009) [+] Integrating Diagnostics with Therapeutic Strategies in Chronic Myeloid Leukemia (2009) [+] Heterogeneous Cancer Progression from Microarray Data (2009) [+] Multiplexed Measurement of Kinase Activity in Single Cancer Cells (2009) [+] Interaction of anti-angiogenic and cytotoxic therapies in colorectal cancer (2009) [+] Refining and Validating Genomic Signatures in Lung Cancer (2009) [+] Uveal Melanoma Micrometastasis (2009) [+] Genomic Complexity and Clinical Outcome in Chronic Lymphocytic Leukemia (2009) [+] Transposon-based screens for colorectal cancer genes (2009) [+] Prognostic markers for ovarian cancer (2009) [+] Prospective Validation of Genomic Signatures of Chemosensitivity in NSCLC (2009) [+] Analysis of Redox Modulated Signaling Networks in Response to Ionizing Radiation (2009) [+] Biomarker-Driven Src Inhibitor Studies in Colorectal Cancer Patients (2010) [+] Molecular and Cellular Characterization of Prognostic Immune Response in Childhoo (2010) [+] Hedgehog signaling in head and neck cancer stem cells, and its role in resistance (2010) [+] Lung cancer heterogeneity and its impact on drug resistance. (2010) [+] Exploiting Biological Networks to Improve Clinical Treatment of Ovarian Cancer (2010) [+] Genetic Basis of Signaling Heterogeneity in Human Follicular Lymphoma (2011) [+] Personalizing NSCLC Therapy: Exploiting KRAS activated pathways (2011) [+] Translational phosphoproteomics for lung cancer (2011) [+] Infant and Toddler Brain Tumors (2011) [+] Cellular and Genetic Basis of Anaplastic Medulloblastoma (2011) [+] Markers and therapeutic strategies for overcoming chemoradiotherapy resistance (2011) [+] Assaying GBM growth and therapy response in single cells and tumorspheres (PQ17) (2012) [+] LACE-Bio-II: Identification, validation and implementation of prognostic and/or p (2012) [+] Design of MEK Inhibitor Regimens for the Treatment of Pancreatic Cancer (2012) [+] Single-Cell Sequencing of Breast Tumors to Investigate Genome Evolution (2012) [+] Targeting the Oncogenic Transcription Factor c-myb in Adenoid Cystic Carcinomas (2012) [+] Genetics pathways in intra-hepatic cholangiocarcinoma (2013) [+] Overcoming acute, adaptive BRAF inhibitor resistance in melanoma (2013) [+] Genetic Biomarkers for Risk Assessment of Peripheral T-Cell Lymphomas (2013) [+] Prognostic and Functional Role of microRNAs in Melanoma Brain Metastasis (2013) [+] Bioinformatics Tools for Genomic Analysis of Tumor and Stromal Pathways in Cancer (2013) [+] Identification of Melanoma Brain Metastasis Tumor Biomarkers (2013) [+] ANALYSIS AND THERAPEUTIC TARGETING OF BREAST CANCER DISSEMINATED TUMOR CELLS (2013) [+] Imaging Guided Genomics of Malignant Transformation (2013) [+] Single-Cell Methods for Analysis of Clonal Heterogeneity and Evolution in Cancer (2013) [+] (PQD5) Predicting Anti-Cancer Efficacy through Tumor Profiling (2014) [+] (PQD3) Mechanisms of prolonged initial disease-free survival in glioblastoma (2014) [+] (PQD1) An Iterative Approach for Overcoming Evolving Targeted Therapy Resistance (2014) [+] (PQB-4) Single cell analysis strategy for monitoring drug responses of tumors (2014) [+] (PQD1) Clonal heterogeneity and targeted therapy resistance in melanoma (2014) [+] Cellular-level Optical Metabolic Imaging to Predict Drug Response in Cancer (2014) [+] Malignant and Radioresistant Nature of Hypoxic Tumor Cells (2014) [+] (PQD1) lmpact of cytotoxic and targeted therapy on clonal evolution of CLL (2014) [+] (PQD1) Evolution of vemurafenib resistance in circulating melanoma cells (2014) [+] (PQD-5) Patient derived orthotopic xenograft models for drug response prediction (2014) [+] Integrated genomic analysis and multi-scale modeling of therapeutic resistance (2014) [+] Integrated models for metastatic phenotype and outcome prediction in osteosarcoma (2014) [+] (PQC3) Genomic Diversity and Microenvironment as Drivers of Metastasis in DCIS (2014) [+] Dynamical Models of Cetuximab Resistance in HNSCC Based on Serial Genomics Data (2014) [+] Statistical methods for genomic analysis of heterogeneous tumors (2014) [+] GENOMIC HARBINGERS OF BRAIN METASTASIS IN NON SMALL CELL LUNG CANCER (2014) [+] (PQD2)New Biomarkers and Pathways to Enhance Cure in Ovarian Cancers (2014) [+] Defining the impact of clonal evolution on chronic lymphocytic leukemia (2014) [+] Microfluidic Device to Profile Chemosensitivity in Glioma Slice Cultures (2014) [+] (PQ #4) Single cell barcoding for studies of study clonal evolution in glioblasto (2014) [+] Biomarkers of Hormone Therapy Response in a Multicenter Prostate Cancer Trial (2014) [+] (PQD3)Molecular Profiles associated with Long-Term Survival in pancreas Cancer (2014) [+] (PQD5) Mass Profiling Melanoma Responses to Improve Therapy Choices and Prognosis (2014) [+] Therapeutic Strategies for Patients With BRAF Mutant Colorectal Cancer (2014) [+] The adaptive kinome in pancreatic cancer (2015) [+] Validation of Quantitative 11C-Erlotinib PET for Imaging EGFR-Mutant Lung Cancer (2015) [+] (PQB4) Stochastic Profiling of Functional Single-Cell States Within Solid Tumors (2015) [+] Genetic evolution of glioblastomas during radiation and temozolomide therapy (2015) [+] (PQC3) Ethnicity-determined immune response and DCIS outcome (2015) [+] Illuminating molecular targetable pathways in HNSCC (2015) [+] Noninvasive monitoring of lung cancer patients treated with radiotherapy (2015) [+] Targeting the Immune System in Mouse Models of Lung Adenocarcinoma (2015) [+] (PQD-3) Spatiotemporal Molecular Interrogation of Early Metastatic Evolution In Situ (2015) [+] Development of high throughput screening technologies in breast cancer (2015) [+] Leveraging Genetically-Engineered Mice to Optimize Pediatric Glioma Management (2015) [+] The identification of genetic determinants of melanoma recurrence (2015) [+] Mouse Models of Metastatic Triple-Negative Breast Cancer for Therapeutic Testing (2015) [+] Tumor Heterogeneity and Acquired Resistance to EGFR Inhibition (2015) [+] A scalable platform for target validation in GEMM models of gastrointestinal malignancies. (2015) [+] Therapeutic targeting of Fibroblast Growth Factor Receptors in Squamous Cancers (2015) [+] Molecular Characteristics of Treatment-resistant High-risk Neuroblastoma (2016) [+] Modeling KRAS genetic heterogeneity in mouse models (2016) [+] Integrative statistical models for TNBC biomarker discovery (2016) [+] MicroRNA Biomarkers for Determining Treatment Response in Colorectal Cancer (2016) [+] Analysis of drug response in organoids and mouse models (2016) [+] Biomimetic hydrogel niches to study the malignant phenotype of glioblastoma multiforme (2016) [+] Glioblastoma, Glioblastoma Stem Cells and Radiotherapy (2016) [+] Tumor subtypes and therapy response in pancreatic cancer (2016) [+] DEFINING RISK FACTORS FOR NF1-OPTIC GLIOMA (2016) [+] Pharmacogenomic and circulating tumor cell approach to individualized treatment of pancreatic cancer (2016) [+] Using genetically engineered mouse models of brain tumors to develop therapeutic nanoparticles & biomaterials (2016) [+] Circulating Tumor Cells Analyses and Molecular Profiling for Patients Receiving Radiation Therapy (2016) [+] Single Cell Sampling of Signaling Activity in Triple Negative Breast Cancer (2016) [+] Determinants of acquired resistance in small cell lung cancer (2016) [+] Cell free nucleic acid-based biomarkers in advanced prostate cancer (2017) [+] Systems Modeling of Tumor Heterogeneity and Therapy Response in Colorectal Cancer (2017) [+] Integration of Genomic and Clinical Data to Enhance Subtyping of Colon Cancer (2017) [+] Optical imaging of pancreas cancer organoids for drug development and personalized treatment (2017) [+] Characterizing TP53 and PPM1D mutations as resistance drivers to radiation therapy in Diffuse Intrinsic Pontine Gliomas (2017) [+] Secondary Prevention through Surveillance and Intervention (2017) [+] (PQ1) Identifying and targeting human glioblastoma migrating in the peritumoral niche (2017) [+] Credentialing murine models for glioblastoma preclinical drug development (2017) [+] Next-Generation Mouse Models of Endometrial Cancer (2017) [+] Optical imaging to predict cell-level genetic heterogeneity and treatment sensitivity in colorectal cancer (2018) [+] Biological Comparisons Among Three Derivative Models of Glioma Patient Cancers Under Microenvironmental Stress (2018) [+] Drug repurposing in breast cancer (2018) [+] Development of optimal strategies to inhibit ERK signaling in tumors with RAF and MEK mutations (2018) [+] Identification of genomic drivers of brain metastases in lung adenocarcinoma (2018) [+] High-Throughput Screening and Validation of Molecular Targeted Chemoradiosensitizers (2018) [+] Longitudinal models of breast cancer for studying mechanisms of therapy response and resistance (2018) [+] Mechanisms of neuroinflammation in brain metastasis progression (2018) [+] Individualized monitoring of treatment response and resistance in patients with metastatic melanoma (2018) [+] Bioinformatic-Chemical Approach to Credential Molecular Targets to Combat Rapid Chemo-Radiation Resistance in SCLC (2018) [+] Quantitative HER3 PET Imaging for Assessing Resistance and Guiding Therapy (2018) [+] Integrative Somatic and Germline Computational Biology to Redefine Clinical Actionability in Solid Tumors (2018) [+] Eco-Evolutionary dynamics of NSCLC to immunotherapy: Response and Resistance (2018) [+] Profiling signaling activity and gene expression in single, pancreatic adenocarcinoma cells using CE-RNA-Seq (2018) [+] A novel microfluidic device to predict brain cancer prognosis and response to therapy (2018) [+] Racial Differences in Prostate Cancer Molecular Subtyping (2018) [+] Molecular origins and evolution to chemoresistance in germ cell tumors (2018) [+] Genomic Prediction of Doxorubicin-Induced Cardiotoxicity (2018) [+] Epigenomic Reprogramming in Patient Derived Models of Colorectal Cancer (2018) [+] Genomic and functional characterization of a panel of neuroblastoma patient-derived xenografts and cell lines (2018) [+] Using patient-derived models to understand drug responses in SCLC (2018) [+] Forecasting tumor evolution: can the past reveal the future? (2018) [+] A biomarker-driven strategy to guide the use of radiotherapy in non-small cell lung cancer (2018) [+] Shapeshifters in Cancer: Defining the Fundamental Forces of Leukemia Evolution (2018) [+] Creating a Catalog of Cancer Clonotype Drug Sensitivities with Single-Cell Genome Sequencing (2018) [+] Defining Epidrivers of CLL Evolution in Response to Targeted Therapy (2018) [+] Longitudinal therapeutic monitoring of colorectal cancer patients using exosome-based liquid biopsies (2018) [+] Pre-Clinical Novel Radiosensitizer Evaluation Program for Brain Tumors (2018) [+] (PQ3) Integrative biomarkers of cancer progression and therapeutic response from germline and somatic clinical sequencing (2019) [+] Age associated genomic instability and brain tumor risk (2019) [+] Germ-line miRNA binding site variants as biomarkers of toxicity and response to checkpoint inhibition (2019) [+] Kinome-guided Targeting of Cooperative Dependencies in BRAF and KRAS Mutated Colorectal Cancer (2019) [+] Investigation of a Novel Cancer Stem Cell Population in Ependymoma. (2019) [+] Integrated Informatic and Experimental Evaluations of Cancer Chronotherapy (2019) [+] Definition of Immune Infiltrate Phenotype and DNA Damage Response Deficits Across Diverse Murine Mammary Carcinomas (2019) [+] Integrators of Metastatic Potential (2019) [+] Predictive Modeling of the EGFR-MAPK pathway for Triple Negative Breast Cancer Patients (2019) [+] Identification of adaptive response mechanisms in breast cancer by information theory and proteomics (2019) [+] INVESTIGATING TUMOR INITIATION AND INVASION IN PREMALIGNANT BREAST CANCER WITH SPATIAL SINGLE CELL GENOMICS (2019) [+] Optimal control models of epithelial-mesenchymal transition for the design of pancreas cancer combination therapy (2019) [+] Developing Bioinformatic and Microfluidic Single Cell Methods for Studying Intratumoral Heterogeneity in Acute Myeloid Leukemia (2019) [+] Impact of chromosomal instability on sensitivity to microtubule-targeting drugs in breast cancer (2019) [+] Uncovering the Biology of Resistance to Tyrosine Kinase Inhibitors in EGFR Mutant Lung Cancer Patient-Derived Models. (2019) [+] Characterization of high-grade serous ovarian cancer subtypes via single-cell profiling (2019) [+] Subpopulations of Pancreatic Cancer Cells Defined by Glycan Markers (2019) [+] Studies on the effects of a novel intermittent therapy on intratumoral clonal architecture and resistance (2019) [+] Translating Intestinal Radioprotection by EGLN Inhibition to Improve Clinical Outcomes in Unresectable Pancreatic Cancer (2019) [+] Credentialing a Cross-Species Platform to Investigate Cancer Therapy-Associated Cardiovascular Toxicity (2019) [+]
	L1D337 (1.4)	L1T10 (18%): liquid_biopsy (1%), circulating_tumor (1%), stratify (1%), blood-based (1%), risk_stratification (1%) L1T24 (11%): a-dependent (0%), p95c (0%), hayward (0%), lievchip (0%), qname-pro (0%) L1T158 (6%): screening (5%), management (3%), surveillance (3%) L1T188 (6%): biomarkers (14%), early_stage (9%), blood (8%), biomarker (8%) L1T129 (5%): markers (11%), prognostic (9%), prognosis (5%) L1T97 (5%): early_detection (14%), diagnosis (13%), detection (9%), diagnostic (8%)	P53 &FIBROCYSTIC DISEASE--INCREASED BREAST CANCER RISK (1992) [+] MULTIPARAMETER FLOW CYTOMETRIC ANALYSIS OF SOLID TUMORS (1992) [+] SECONDARY PREVENTION OF LIVER CANCER IN HAIMEN, CHINA (1993) [+] CYCLIN D1 AS BIOMARKER OF BREAST CANCER RISK (1999) [+] GENETIC MARKERS OF BLADDER CANCER PROGRESSION (2001) [+] Prognostic Markers for Primary Cutaneous Melanoma (2002) [+] ORAL CANCER: MOLECULAR PROFILES &CLINICAL OUTCOMES (2003) [+] Molecular Analysis of Human Breast Cancer (2003) [+] Molecular Classification of Endometrial Carcinomas (2004) [+] Protein Biomarkers of Cancer Risk in Older Persons (2005) [+] Melanoma RAS/BRAF Mutation--Heterogeneity-Risk-Prognosis (2005) [+] Multianalyte Assay For Early Diagnosis Of Ovarian Cancer (2005) [+] Molecular Classification of Suspicious Thyroid Tumors (2005) [+] Discovery of Biomarkers for Lung Cancer Metastasis (2005) [+] Peripheral Blood Molecular Staging of Breast Cancer (2006) [+] Extending and Interpreting Molecular Portraits of Cancer (2006) [+] Chip-Based Diagnosis of Problematic Liver Tumors (2006) [+] KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA (2006) [+] Validation of Prognostic and Diagnostic molecular tests in Mesothelioma (2006) [+] Proteomic Analysis of Serum in Liver Cancer (2007) [+] Molecular Determinants of Oral Tongue Cancer Metastasis (2008) [+] Risk Prediction for Breast Cancer: A Tissue-Based Strategy (2008) [+] Integrative Metabolomics of Prostate Cancer Progression (2008) [+] Molecular Characterization of Stage I Lung Cancer (2008) [+] Biomarker Discovery for the Classification of Melanoma (2008) [+] Development and Validation of a Panel of Breast Cancer for the Early Diagnosis of (2008) [+] Molecular signatures of melanoma histology and progression: A Population Based A (2009) [+] Design and Validation of a Biomarker-enhanced System to Predict RCC Progression (2010) [+] Detection of Carcinomas (2011) [+] Multicenter Genetic, Epigenetic &Expression Analysis of DCIS outcome predictors (2011) [+] Non-invasive Biomarker Panels for Early Detection of Lung Squamous Cell Carcinoma (2011) [+] A Novel Approach for the Routine Screening for Ovarian Cancer (2012) [+] Mechano-Visual Phenotyping of Cancer: From Onset Through Disease Progression (2012) [+] Multi-phase Microfluidic Devices for Characterization of Circulating Tumor Cells (2012) [+] Epidemiologic factors and survival by molecular subtypes of ovarian cancer (2013) [+] (PQA4) Point-of-Care Test of Exposure to Hepatocellular Carcinoma Risk by V-Chip (2013) [+] Early detection of pancreatic cancer in diabetics (2014) [+] Collagen structural changes as an early biomarker for breast carcinoma (2015) [+] FFPE Validation of a Survival Gene Signature in HPV-Negative Oral Cavity Cancer (2015) [+] Discovery and verification of novel biomarkers of colorectal cancer recurrence (2015) [+] Using Stromal Markers to Improve Risk Stratification of Ductal Carcinoma in Situ (2015) [+] Identification of DNA methylation markers for risk of metastasis in localized pro (2015) [+] A New Lab Based Algorithm for HCC Surveillance in Patients with Cirrhosis (2015) [+] Genomic and Morphologic Predictor of High-Risk DCIS (2016) [+] Transforming the diagnosis and care of patients with CTCL using TCR sequencing (2016) [+] Early Detection of Ovarian Cancer Through Epigenetic Factors in the WHI (2016) [+] Computerized histologic image predictor of cancer outcome (2016) [+] Real-time monitoring of circulating pancreatic tumor cells and clusters (2016) [+] Redefining Normal: personalized CA125 cutpoints for ovarian cancer screening (2016) [+] Circulating plasma tumor DNA as a biomarker for early stage breast cancer (2016) [+] Early Detection of Hepatocellular Carcinoma (2016) [+] Individualizing colorectal cancer patient care using the host and tumor telomere phenotype (2016) [+] A partnership to enable clinical ctDNA testing for breast cancer recurrence (2016) [+] Multiplexed isoform quantification in HER2-positive breast cancer (2016) [+] 3D Prostate Histochemometry to Predict Disease Recurrence (2016) [+] Development of cell-free DNA assays for HCC screening and liquid biopsy (2016) [+] Metabolomic Strategies for Discovery and Validation of Biomarkers of Colorectal Cancer Recurrence (2017) [+] Development of a Four-Class, Molecular Subtyping Diagnostic for HPV-negative Head and Neck Cancer (2017) [+] Circulating DNA methylation biomarkers in micrometastatic breast cancer (2017) [+] Molecular markers of risk of subsequent invasive breast cancer in women wth ductal carcinoma in situ (2017) [+] Translation of a Clinical Molecular Diagnostic Assay for Bladder Cancer (2017) [+] A population-based approach to single CTC analysis in metastatic breast cancer outcome (2017) [+] The UCLA Center in Early Detection of Liver Cancer (2018) [+] A microfluidic blood-based test to monitor treatment response in glioblastoma (2018) [+] Earlier Detection of Cancers using Non-Plasma Based Liquid Biopsies (2018) [+] Comprehensive minimal residual disease tracking in cancer (2018) [+] Lipid nanoprobe integrated microdevice for extracellular vesicle isolation and duplex sequencing based mutation detection for non-invasive lung cancer diagnosis (2018) [+] Circulating Biomarkers and Imaging for Early Detection of Pancreatic Cancer (2018) [+] Interrogating malignant gliomas using released tumor DNA in cerebrospinal fluid (2018) [+] A comprehensive liquid biopsy platform for detection and prognostication in early stage breast cancer (2018) [+] Discovery and validation of early molecular breast cancer risk markers in benign breast disease (2018) [+] Quantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal Carcinoma (2018) [+] Multiregional imaging phenotypes and molecular correlates of aggressive versus indolent breast cancer (2018) [+] Precision Risk Stratification and Screening for HCC among Patients with Cirrhosis in the United States (2018) [+] Background free amplified single-molecule FISH for in situ and flow cytometric applications (2018) [+] Profiling genome-wide circulating ncRNAs for the early detection of lung cancer (2018) [+] Molecular complete response in blood as a predictor for pathologic complete response after neoadjuvant therapy for breast cancer (2018) [+] Lung Cancer Screening via Ultrasensitive and Cost-efficient Analysis of Tumor DNA Signatures in Blood (2018) [+] Computerized Histologic Risk Predictor (CHiRP) for Early Stage Lung Cancers (2018) [+] Radiogenomic Biomarkers of Breast Cancer Recurrence (2018) [+] Risk Stratification for and Early Detection of Liver Cancer (2018) [+] Predicting Breast Cancer Risk after Benign Percutaneous Biopsy (2018) [+] Precision Screening for Hepatocellular Carcinoma in Patients with Cirrhosis (2018) [+] Pathway Specific Functional Biomarkers for the Early Detection of Liver Cancer (2018) [+] NOVEL STRATEGIES TO IMPROVE LIVER CANCER SURVEILLANCE UPTAKE AND EARLY DETECTION (2018) [+] Liquid Biopsy for treatment stratification of IDH1.R132H and EGFRvIII mutant gliomas (2018) [+] Deep Ovarian Cancer Metabolomics (2018) [+] Statistical Methods For Quantitative Immunohistochemistry Biomarkers (2019) [+] Microengineered Technologies for Quantitative, Multiplexed and Spatially Resolved Measurement of miRNA in Tissue Sections (2019) [+] Use of Circulating MicroRNAs for Early Detection and Risk Assessment for Pancreatic Cancer (2019) [+] HistoTools: A suite of digital pathology tools for quality control, annotation and dataset identification (2019) [+] 3D carbon-nanotubes integrated microdevice for extracellular vesicle isolation and in situ sample preparation towards noninvasive pancreatic cancer diagnosis (2019) [+] Biomarker screening algorithms for the improved early detection of hepatocellular carcinoma (2019) [+] Circulating lipid and miRNA markers for early detection of breast cancer among women with abnormal mammograms (2019) [+] Pre-analytical factors affecting ctDNA analysis in early and locally advanced breast cancer (2019) [+] Multimodal Biomarkers For Oropharyngeal Cancer (2019) [+] Translation of a biomarker panel for the early detection of hepatocellular carcinoma (2019) [+] Plasma and saliva biomarkers of disease status in HPV related oropharynx cancer (2019) [+] Colorectal cancer risk factors, risk prediction and blood-based biomarker by tumor consensus molecular subtype (2019) [+]
	L1D290 (1.6)	L1T46 (19%): sera (4%), glycans (4%), glycan (4%), glycoforms (4%), glycoproteins (3%) L1T10 (12%): candidate_biomarkers (4%), workflows (3%), glycan_structure (2%), glycomics (2%), glycomic (2%) L1T97 (7%): early_detection (15%), diagnostic (11%), detection (10%) L1T188 (6%): biomarkers (17%), biomarker (12%), samples (11%), early_stage (10%), blood (9%) L1T114 (5%): hepatocellular_carcinoma_hcc (10%), hcc (9%), liver_cancer (7%), cirrhosis (6%) L1T156 (3%): method (8%), methods (7%), spots (5%), extraction (4%), quantitative (4%)	DIAGNOSTIC ASSAY FOR 1, I ANTIGENS IN BREAST CARCINOMA (1986) [+] TUMOR ANTIGEN CA125 IN OVARIAN CANCER PATIENTS (1986) [+] URINARY HCG FREE B-SUBUNIT/FRAGMENT--GYNECOLOGIC CANCER (1988) [+] TECHNOLOGIES FOR IDENTIFYING PROTEINS SECRETED BY TUMORS (1997) [+] EARLY DETECT/CHARACTERIZATION OF TUMOR CELLS IN BLOOD (1999) [+] Novel Approaches to Detect Virus-Cancer Associations (2002) [+] Identification of Early Markers for Ovarian Cancer (2003) [+] Liquid Proteomics for Marker Screening of Ovarian Cancer (2003) [+] Autoantibodies in NSCLC as Markers for Disease (2003) [+] Molecular Diagnostics for Malignant Effusion (2004) [+] Protein Microarrays for the Humoral Response in Cancer (2004) [+] Early antibody markers of HCC (2005) [+] Detection and Diagnosis of Pancreatic Cancer (2005) [+] Pancreatic Cancer Protein Biomarkers for Early Detection (2006) [+] Identification of Altered Glycan and Glycoproteins in Viral Induced Liver Cancer (2006) [+] Discovery and validation of novel serological biomarkers of colon cancer (2006) [+] Tumor-Associated Antigens in Early Stage Serous Carcinoma (2006) [+] MUC-1 related cancer immunity: determinants and predictive significance (2006) [+] R01-Proteomic characterization of alternate splicing and cSNP protein isoforms (2006) [+] Molecular Classification of Primary Cutaneous Melanoma (2007) [+] Distinctive Glycan Fingerprints of Pancreatic Cancer for Plasma Detection (2009) [+] Liver Cancer and the Role of Protein Hyper-Fucosylation (2009) [+] Glycan Biomarkers of Prostate Cancer in Prostatic Fluids (2009) [+] Markers for HCV-related HCC: plasma profiling, targeted strategies and validation (2009) [+] Identification of ovarian cancer plasma biomarkers (2009) [+] Glycans in Hepatocellular Carcinoma (2009) [+] Serum glycoprotein markers of cancer using an ion mobility/mass spec approach (2011) [+] Biomarkers of Opisthorchis viverrini-induced cholangiocarcinoma (2011) [+] Validation of an Antibody Test for Early Diagnosis of Ovarian Cancer (2011) [+] A+PSA Assay for Improved Prostate Cancer Diagnosis and Risk Assessment (2012) [+] Serum Glyco-Markers of Early Hepatocellular Carcinoma Using a Mass Spec Approach (2012) [+] 3-Dimensional profile of circulating miRNA for early cancer detection (2015) [+] Protein and proteolytic activity biomarkers of early stage pancreatic cancer (2017) [+] LC-MS Analysis of Site Specific Protein Glycoforms (2018) [+] Isolation and Assessment of Blood-Circulating Cancer Exosomes with LSS and SERS Lab on a Chip Optical Spectroscopic Instrument (2018) [+] Glycomics Laboratory for the Development of Ovarian Cancer Biomarkers (2018) [+] Screening of Glycan Markers in Serum for Early Detection of HCC in Different Etiologies of Disease (2018) [+] Effect of methodological and biological variability on molecular profiling of extracellular vesicles in cancer detection (2018) [+] Glycosylation and Immune Evasion in Urologic Tumors (2019) [+] Simplified Glycan Profiling Workflows of Captured Immune Glycoproteins and Cells (2019) [+] Glycopathology of HCC: identification of the source cells of serum fucosylation (2019) [+] O-glycoproteins in the progression of liver disease (2019) [+]
	L1D261 (1.5)	L1T159 (31%): families (7%) L1T127 (11%): linkage_analysis (4%), genetic_markers (3%), familial_aggregation (2%), genetic_epidemiology (2%), candidate_genes (2%) L1T157 (7%): mutations (14%), genetic (11%) L1T57 (6%): family_history (8%)	GENETIC EPIDEMIOLOGY OF CHILDHOOD SARCOMA (1985) [+] INHERITANCE OF DISCRETE COLORECTAL ADENOMATOUS POLYPS (1985) [+] GENETIC EPIDEMIOLOGY OF MALE AND FEMALE BREAST CANCER (1986) [+] HEREDITARY NONPOLYPOSIS COLORECTAL CANCER RESOURCE (1986) [+] PATHOLOGY DISCRIMINANTS AND CANCER CONTROL IN HNPCC (1987) [+] INHERITANCE &MARKERS OF COLORECTAL CANCER &POLYPS (1987) [+] GENETIC MAPPING OF FAMILIAL MEDULLARY THYROID CARCINOMA (1988) [+] CONTROL OF COLON CANCER THROUGH FAMILIAL RISK ASSESSMENT (1988) [+] GENE PROBES IN THE FAMMM (1988) [+] PLASMA LIPIDS AND FAMILIAL BREAST CANCER (1989) [+] LINKAGE STUDIES IN HEREDITARY BREAST CANCER (1989) [+] CANCER RISK OF ATAXIA-TELANGIEGTASIA HETEROZYGOTES (1990) [+] BREAST CANCER AMONG BLACK WOMEN--G &E INTERACTIONS (1991) [+] EPIDEMIOLOGIC AND GENETIC STUDIES OF BREAST CANCER (1992) [+] MOLECULAR EPIDEMIOLOGY OF WILM'S TUMOR (1992) [+] LOSS OF HETEROZYGOSITY IN BILATERAL BREAST CANCER (1993) [+] GENETIC ANALYSIS OF OVARIAN CANCER (1993) [+] GENE/ENVIRONMENT STUDY OF FAMILIAL COLORECTAL CANCER (1994) [+] GENETIC EPIDEMIOLOGY OF HEREDITARY COLONIC CANCERS (1994) [+] MAPPING COLORECTAL CANCER SUSCEPTIBILITY LOCI (1994) [+] POPULATION BASED GENETIC ANALYSIS OF BREAST CANCER (1994) [+] GENETIC AND ENVIRONMENTAL DETERMINANTS OF BREAST CANCER (1994) [+] GENETIC/EPIDEMIOLOGY STUDY OF EPITHELIAL OVARIAN TUMORS (1994) [+] PREVENTION OF HEREDITARY BREAST AND OVARIAN CANCER (1994) [+] BPH AND PROSTATE CA IN 5A-REDUCTASE-2 DEFICIENT CARRIERS (1994) [+] HEREDITARY BREAST CANCER--GENETIC AND MOLECULAR STUDIES (1994) [+] MOLECULAR GENETIC STUDY--COLORECTAL CANCER EPIDEMIOLOGY (1994) [+] PROSTATE CANCER MOLECULAR GENETICS IN AFRICAN AMERICANS (1995) [+] 5ALPHA REDUCTASE GENOTYPE, RACE AND PROSTATE CANCER RISK (1995) [+] INHERITED MSH2/MLH1 MUTATIONS IN COLON CANCER SUBGROUPS (1995) [+] CANCER RISK ASSESSMENT--CLINICAL AND MOLECULAR TOOLS (1995) [+] GENETIC ANALYSIS USING THE GILDA RADNER REGISTRY (1995) [+] GENETIC MAPPING OF NON-BRAC1 BREAST AND OVARIAN CANCER (1995) [+] RESEARCH IN CANCER EPIDEMIOLOGY AND BIOSTATISTICS (1995) [+] FAMILIAL AGGREGATION AND COAGGREGATION OF CANCER (1996) [+] COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER (1996) [+] PREVALENCE OF BRCAL--A POPULATION BASED STUDY (1996) [+] GENETIC AND MOLECULAR EPIDEMIOLOGY OF GLIOMAS (1996) [+] BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK (1996) [+] GENETIC MECHANISM OF BRCA1 LINKED OVARIAN TUMORIGENESIS (1996) [+] ETIOLOGY OF EARLY BREAST MALIGNANCY (1996) [+] ECOGENETICS OF PANCREATIC CANCER--FAMILY REGISTRY (1997) [+] ETIOLOGIC HETEROGENEITY IN LATE ONSET BREAST CANCER (1997) [+] INHERITED BREAST CANCER IN CHINESE WOMEN (1997) [+] LOCALIZATION OF SUSCEPTIBILITY LOCI IN PROSTATE CANCER (1997) [+] DEFECTIVE DNA MISMATCH REPAIR IN ENDOMETRIAL CANCERS (1997) [+] EVALUATION OF PREDICTORS FOR RECURRENT ADENOMAS (1997) [+] ANDROGEN PATHWAY POLYMORPHISMS AND PROSTATE CANCER RISK (1997) [+] MOLECULAR GENETICS OF HNPCC (1997) [+] GENETIC/EPIDEMIOLOGY OF BREAST/PROSTATE CANCER (1997) [+] GENETIC EPIDEMIOLOGY OF BREAST CANCER--BRCA1 AND BRCA2 (1998) [+] MOLECULAR EPIDEMIOLOGY OF OVARIAN CANCER (1998) [+] BRCA1 AND BRCA2 IN AFRICAN-AMERICAN AND LATINO FAMILIES (1998) [+] CANCER AND MORTALITY IN NEUROFIBROMATOSIS BY GENOTYPE (1999) [+] ANDROGEN RECEPTOR AND PROSTATE CANCER RISK IN CHINESE (1999) [+] MAMMOGRAPHIC DENSITY &RISK OF HEREDITARY BREAST CANCER (1999) [+] GENETIC EPIDEMIOLOGY OF PROSTATE CANCER (1999) [+] GENETICS OF PROSTATE CANCER SUSCEPTIBILITY (1999) [+] POPULATION BASED STUDIES OF BRCA1 (1999) [+] PREDISPOSING/MODIFYING GENES IN HEREDITARY COLON CANCER (1999) [+] NATURAL HISTORY OF HEREDITARY BREAST CANCER (2000) [+] RISK ESTIMATION AND MODIFIER GENES IN INHERITED CANCER (2000) [+] The Risk of Cancer in Fanconi Anemia Heterozygotes (2001) [+] PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION (2001) [+] INHERITED MSH6 MUTATIONS IN DIVERSE COLORECTAL CANCERS (2001) [+] P53 in BBD and Breast Cancer Risk: A Multicenter Cohort (2002) [+] Genetics of Breast Cancer in Blacks (2002) [+] A Genetic Linkage Study of Testicular Cancer (2004) [+] Modifiers of Cancer Risk in BRCA 1/2 Mutation Carriers (2004) [+] GENETIC LINKAGE IN COLORECTAL CANCER FAMILES (2004) [+] Gene Interactions, Estrogen, and Risk of Breast Cancer (2004) [+] The role of the ATM gene in familial breast cancer (2005) [+] Prognosis in BRCA1 Associated Breast Cancer (2005) [+] Ovarian Cancer and Mismatch Repair Deficiency (2005) [+] Epidemiology of Syndromic GI Stromal Tumors (2007) [+] BRCA2 missense mutations and breast cancer (2007) [+] DNA Damage-Response Defects in Prostate Cancer Risk (2007) [+] A genome-wide association study for breast cancer in BRCA1 mutation carriers (2008) [+] Validation and extension of the PREMM Model for mismatch repair gene mutations (2008) [+] The Meningioma Consortium: Genome-Wide Association Study (2010) [+] Development of a comprehensive model for colorectal cancer risk prediction (2012) [+] Genome-Wide Association Study of Mammographic Density (2012) [+] Classifying DNA Mismatch Repair Gene Variants of Unknown Significance (2013) [+] Risk and penetrance of mutations from breast cancer testing panels. (2014) [+] Determinants of genetic penetrance in identical twins with breast cancer (2016) [+] The contribution of RAD51C and RAD51D to breast and ovarian cancer (2018) [+] Combined NGS tumor-based detection of germline Lynch syndrome mutations and prognostic classification of endometrial cancers (2018) [+] Precision approaches to refining TP53-associated cancer risk (2019) [+]
	L1D269 (1.5)	L1T24 (15%): telomere_length (4%), mutagen_sensitivity (3%), telomeres (3%), telomere_maintenance (2%), telomere (2%) L1T127 (11%): polymorphisms (6%), genetic_susceptibility (4%), xpd (3%) L1T57 (10%): environmental_exposures (3%), case-control_study (3%), family_history (2%), risk_factors (2%) L1T1 (7%): dna_repair (9%) L1T21 (6%): cohort (5%), subgroups (3%), largest (3%), gender (3%), matched (2%) L1T106 (5%): cases (13%), exposure (11%), controls (11%), etiology (7%)	CARCINOGEN DOSIMETRY AND ONCOGENE ACTIVATION (1985) [+] FOLLOW-UP OF PATIENTS X-IRRADIATED FOR SCALP RINGWORM (1986) [+] MUTAGEN SENSITIVITY IN HIGH BREAST CANCER RISK PATIENTS (1987) [+] MULTIPLE PRIMARY CANCERS AND MUTAGEN HYPERSENSITIVITY (1991) [+] ROLE OF DNA REPAIR IN SUSCEPTIBILITY TO SKIN CANCER (1992) [+] P53 MUTATIONAL SPECTRUM IN LUNG TUMORS FROM NONSMOKERS (1993) [+] GENETIC SUSCEPTIBILITY TO LUNG CANCER (1993) [+] DRUG METABOLIZING ENZYMES--RISK FACTORS IN BLADDER CA (1994) [+] GENETIC EPIDEMIOLOGY OF LUNG CANCER (1995) [+] HUMAN SUSCEPTIBILITY TO GENETIC DAMAGE AND SKIN CANCER (1995) [+] MOLECULAR EPIDEMIOLOGY OF CUTANEOUS MALIGNANT MELANOMA (1996) [+] MUTAGEN SENSITIVITY &PROGRESSION IN BARRETTS ESOPHAGUS (1996) [+] MOLECULAR EPIDEMIOLOGY OF DNA REPAIR IN MELANOMA (1996) [+] MOLECULAR EPIDEMIOLOGY AND PREVENTION OF BREAST CANCER (1997) [+] IDENTIFICATION AND CONTROL OF CANCER RISK (1997) [+] MUTAGENICITY OF AZT IN CHILDREN OF HIV-INFECTED WOMEN (1997) [+] MARKERS FOR LUNG CARCINOGENESIS IN BRONCHIAL EPITHELIUM (1997) [+] GENETIC SUSCEPTIBILITY TO LUNG CANCER (1997) [+] IN VIVO GENTOXICITY TO HEMOPOIETIC STEM CELLS (1998) [+] GENETIC SUSCEPTIBILITY TO BLADDER CANCER (1999) [+] MOLECULAR EPIDEMIOLOGY OF NON-MELANOMA SKIN CANCER (1999) [+] ALPHA 1 AD CARRIERS AND LUNG CANCER RISK (2000) [+] METABOLIC GENOTYPES &ONCOGENIC DAMAGE IN BREAST CANCER (2000) [+] TELOMERASE AS A PROGNOSTIC INDICATOR FOR WILMS TUMOR (2000) [+] GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY (2001) [+] Gene Environment Interaction in Head and Neck Cancer (2001) [+] Molecular Epidemiology of Melanoma (2002) [+] Host factors and etiology of leukemia (2002) [+] Interaction of Radiation, BRCA1/2, and Breast Cancer (2002) [+] Genetic Susceptibility Modifiers in Renal Cell Carcinoma (2003) [+] DNA Repair Gene Polymorphysms and Pancreatic Cancer (2003) [+] Renal cancer genomic alterations and environmental risk (2003) [+] Molecular Biomarkers as Predictors of Hodgkin's Disease (2003) [+] Quantitative Gene Expression in Human Lung Epithelium (2003) [+] Molecular Epidemiology of Smoking &Breast Cancer (2003) [+] Genetics of Tobacco and Alcohol Related Cancers (2003) [+] Repair &Prevention of DNA Damage &Breast Cancer Risk (2003) [+] Molecular Epidemiology of Secondary Lung Cancer (2003) [+] Lung cancer molecular markers by sex: intergroup study (2004) [+] Chromosome 6p21-24 Markers in HIV-Related Kaposi Sarcoma (2004) [+] Molecular Studies of Bone Marrow Failure (2004) [+] Indoor Tanning Use, DNA Repair and Risk of Melanoma (2004) [+] Genetic Predictors for DNA Repair Phenotype in CMM (2004) [+] Factors for Epigenetic Silencing of Lung Cancer Genes (2004) [+] Radiation Sensitivity, DNA Repair and Second Cancers (2004) [+] DNA Repair, Skin Cancer and Overall Cancer Risk (2005) [+] Molecular Epidemiology of Colorectal Cancer Subtypes (2005) [+] TGF-beta pathway variants and breast cancer in families (2005) [+] Solar Exposure and Melanoma Survival (2005) [+] Breast Cancer, Radiation and the ATM-CHEK2 Pathway (2005) [+] Gender Differences in Bladder Cancer Risk Factors (2006) [+] TGF-beta pathway polymorphisms and colon cancer risk (2006) [+] Chromosomal Aberrations and Risk for Familial Lung Cancer (2006) [+] Parental genotypes and exposures in sporadic retinoblastoma (2007) [+] Prospective Study of DNA Repair Gene Variants in Breast Cancer (2007) [+] Genetic Instability &Risk for Esophageal Carcinoma (2008) [+] Gene-environment EBV Interactions in the Etiology of Nasopharyngeal Carcinoma (NP (2008) [+] Allergic Condition Susceptibility Polymorphisms and Glioma Risk (2008) [+] Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma (2008) [+] The Epidemiology of Molecular Alterations in Mesothelioma (2008) [+] Telomere length, telomere maintenance gene polymorphisms, and bladder cancer risk (2008) [+] Telomere length, telomere maintenance genes and cancer risk (2008) [+] Telomere dysfunction, chromosome 9 instability and bladder cancer risk (2009) [+] Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer (2009) [+] Role of Genetic Susceptibility in Therapy-related Subsequent Malignancies (2010) [+] Molecular Epidemiology of Pediatric Germ Cell Tumors (2011) [+] Telomeres and lung cancer incidence and survival (2011) [+] Epigenetic Changes Link COPD and Lung Cancer (2011) [+] The Role of Telomere Shortening in MDS-AML Pathogenesis (resubmission) (2012) [+] Genome-wide association study of cutaneous squamous cell carcinoma (2013) [+] (PQB4) Age-cancer interplay of genome and epi-genome in human lung (2013) [+] Methylation and mutations in RB1 and variants of synthetic folic acid metabolism (2015) [+] (PQB-1) Telomere maintenance defects and thyroid second cancer in childhood cancer survivors (2015) [+] DNA Repair Capacity Assays for Lung Disease Risk Assessment (2018) [+] Cancer Genetics of Short Telomere Syndromes (2018) [+] Using Clonal and Non-Clonal UV Signature Mutations to Predict Skin Cancer Risk (2019) [+]
	L1D347 (1.3)	L1T121 (16%): pancreatic_cancer (7%), kras (6%), pda (4%), pancreatic (4%) L1T99 (10%): organoid (3%), patient-derived (2%), organoids (2%), targeted_therapies (2%), vulnerabilities (2%) L1T49 (7%): drive (6%), mouse_models (5%), driving (4%), therapeutic_targets (4%), driven_by (3%) L1T50 (6%): our (3%), test (2%), we (2%) L1T15 (4%): subtype (5%), lethal_disease (4%), dismal_prognosis (3%), therapies (3%), dismal (3%) L1T157 (4%): genetic (12%), mutations (11%) L1T130 (4%): lung_cancer (20%), lung (11%), lung_adenocarcinoma (10%)	THYROID-SPECIFIC PTC ONCOGENE (1993) [+] c-Kit Mutations and Their Role in Tumor Biology (2002) [+] Mutant mouse models of exocrine pancreatic cancer (2004) [+] Mouse Model for Human Pancreatic Ductal Adenocarcinoma (2004) [+] Embryonic Signaling Pathways in Pancreatic Cancer (2004) [+] The Role of Beta-catenin Signaling in Malignant Melanoma (2005) [+] Hedgehog Inhibitors in Pancreas Cancer (2005) [+] Preclinical Modeling of Latent Breast Cancer in Mice (2005) [+] Epigenetic Effect of the Microenvironment on Stem Cell Plasticity and Function (2007) [+] Lung Epithelial-Mesenchymal Interactions in Adenocarcinoma Invasion (2007) [+] Kras-Induced Cellular Plasticity in Pancreatic Cancer (2008) [+] Therapeutic Targets in Alveolar Rhabdomyosarcoma (2008) [+] TGF-beta Signaling in Pancreatic Cancer (2008) [+] Smoking and pancreatic cancer (2008) [+] TGF-beta Signaling in Pancreatic Cancer Progression (2009) [+] Targeting Oncogenic ALK Signaling in Neuroblastoma (2009) [+] Phosphatidylinositol 3-kinase and prevention of pancreatic cancer (2009) [+] Molecular Events in the PI3K/Akt Pathway in Thyroid Cancer (2009) [+] Studying the initiation, progression and therapy of lung cancer in mouse models (2009) [+] Hedgehog and EGF interaction: a novel therapeutic approach for pancreatic cancer (2009) [+] Role of CREB in Lung Cancer Development (2010) [+] Investigating Oncogenic Cooperation between BMI-1 and EWS-FLI1 (2010) [+] The GNAQ pathway as a therapeutic target in uveal melanoma (2010) [+] Analysis of the Cellular Origins of Breast Cancer (2010) [+] Genetic Approaches to Pancreatic Cancer Progression (2010) [+] Dissecting Hedgehog, TGF beta and BMP Signaling During Pancreatic Tumorigenesis (2011) [+] Role of PKC iota in metaplasia and initiation of pancreatic cancer (2011) [+] Cellular diversity and clinical relevance of stem cells in pancreatic cancer (2011) [+] Nicotine, nicotinic receptors and lung cancer (2011) [+] Identification and Characterization of Gene Fusions in Lung Adenocarcinoma (2011) [+] RON Receptor in Pancreatic Cancer Biology and Therapy (2011) [+] A Novel Lineage Specific Metastasis Suppressor Pathway in Lung Cancer (2012) [+] Dissecting Tumor Heterogeneity by Analyzing Signaling Pathway Requirements. (2012) [+] IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer (2012) [+] Defining a Role for c-KIT in Melanoma (2013) [+] TXNIP as a Key Regulator of Thyroid Cancer Metabolism and Aggressiveness (2013) [+] Cancer-associated fibroblast in the regulation of bladder cancer stem cells (2013) [+] Molecular Dissection of Lung Cancer Progression and Metastasis (2013) [+] Structure-Functions Studies of Twist1-induced Radioresistance in Lung Cancer (2013) [+] (PQB6) Genetics of Subclonal Evolution in Pancreatic Cancer (2013) [+] PDG Links Stem Cell Niche to Pancreatic Epithelial Renewal, Repair and Cancer (2013) [+] Sirt2 Directs Kras IR Cell Resistance and Tumorigenesis (2014) [+] Fingerprinting Invasive Membrane Protrusions to Discover Metastatic Signatures (2014) [+] Epigenetic regulation of pancreatic cancer (2014) [+] The Yap-Tead transcriptional complex in Kras-induced Pancreatic Ductal Adenocarci (2014) [+] Sox9 signaling in lung adenocarcinoma (2014) [+] Identifying Mechanisms of Sox2-Driven Squamous Cell Lung Cancer (2014) [+] Histone Methyltransferases as a Target for Lung Cancer Prevention (2014) [+] Novel Experimental Therapeutics for Pancreatic Cancer (2014) [+] Targeting BET Bromodomain in Pancreatic Cancer (2014) [+] Pancreatic Cancer Vulnerabilities Downstream of Cooperating Oncogenic Mutations (2014) [+] Crucial Microenvironmental Cofactors for Pancreatic Cancer Pathogenesis (2014) [+] Novel mechanisms of oncogenic transformation in lung cancer (2014) [+] Iron addiction and the biology of ovarian cancer (2014) [+] Evaluation of the BAP1 tumor suppressor gene in renal cell carcinoma (2014) [+] Stellate cells and their progenitor precursors in pancreas cancer progression (2014) [+] Investigation of tumor suppressive miR-148a in IDH mutant gliomas (2014) [+] Novel Therapeutics Targeting INPP5A Pathway in Squamous Cell Carcinoma (2014) [+] PAX3 pathways in melanoma (2015) [+] The role of wild-type KRAS in the context of tumor profession and metastasis (2015) [+] The Role of post-translational activation of Myc in pancreatic cancer (2015) [+] Genetic analysis of ras mutation specificity in skin and lung cancer (2015) [+] A novel miR-198 replacement therapy for pancreatic cancer (2015) [+] Musashi-mediated control of pancreatic cancer growth and progression (2015) [+] Investigating the cell of origin for bladder cancer (2015) [+] Ubiquilin1 regulates EMT and metastasis of human lung adenocarcinoma (2015) [+] Exploitation of RAS signaling to develop therapy and early detection strategies for PDA (2015) [+] (PQ4A) Metabolic Plasticity of Pre-Malignant Cells During Tumor Progression (2015) [+] Clinical Significance of Pancreatic Cancer Differentiation and Dedifferentiation (2015) [+] Oncogenic Function of Ca2+ Channel Orai1 in Esophageal Carcinogenesis (2015) [+] Developing a pharmacologic approach to treat LKB1 mutant NSCLC patients (2016) [+] PKD1 signaling in the initiation of pancreatic cancer (2016) [+] Therapeutic targeting of Kras-driven Lung Adenocarcinoma (2016) [+] Developmental studies to inform clinical stratification and targeting of SHH MB (2016) [+] Suppression of pancreatic tumorigenesis by the PTF1 transcription factor network (2016) [+] Notch signaling in small cell lung carcinoma (2016) [+] Integrated Signaling in Pancreatic Cancer Progression (2016) [+] Molecular and cellular mechanisms of SCLC metastasis (2016) [+] Comprehensive genetic dissection of druggable KRAS targets (2016) [+] Molecular Dissection of an Arntl2 induced pro-metastatic secretome (2016) [+] (PQ1) Epigenetic effects of the premalignant field (2016) [+] (PQ1) Progression of the airway field of injury to Kras mutant lung cancer (2016) [+] Role of enhancer elements in regulating prometastatic transcriptional programs in osteosarcoma (2016) [+] Role of GATA2 signaling network in Lethal Prostate Cancer (2016) [+] Thrombin-dependent mechanisms of pancreatic ductal adenocarcinoma disease (2017) [+] Defining the non-myogenic origins of pediatric rhabdomyosarcoma (2017) [+] JAK1 Signaling in Pancreatic Cancer Initiation and Progression (2017) [+] Exosomes in Cancer Therapy (2017) [+] Transcriptional Regulation of Lung Cancer Identity (2017) [+] The role of PCDH7 in lung cancer pathogenesis (2017) [+] Role of PD2/Paf1 in Pancreatic Acinar to Ductal Metaplasia (2017) [+] Wnt/?-catenin Signaling in Pancreatic Oncogenesis (2017) [+] Nrf2 Regulation of Ductal Pancreatic Cancer Etiology and Treatment Response (2017) [+] Notch signaling in liposarcoma (2017) [+] Frizzled 9 loss and regulation in preventing the progression of pre-malignant lung lesions (2017) [+] Sialylation-dependent mechanisms driving pancreatic cancer progression (2018) [+] Molecular dissection of Lkb1-mediated tumor suppression (2018) [+] CSHL-JAX Patient-Derived Models of Pancreatic Cancer as Systems for Investigating Tumor Heterogeneity (2018) [+] MAPK pathway modulation in thyroid tumorigenesis (2018) [+] The Role of RHOA in Diffuse Gastric Cancer (2018) [+] Molecular Events in the PI3K/AKT Pathway in Thyroid Cancer (2018) [+] BRMS1-mediated suppression of metastases in p53 mutant lung adenocarcinoma (2018) [+] Targeting novel therapeutic vulnerabilities in LKB1 mutant tumors. (2018) [+] Exploiting KRAS addiction for lung cancer therapy (2018) [+] Molecular mechanisms of SCLC initiation and detection in mice and humans (2018) [+] Dissecting the Spectrum, Prevalence, and Molecular Mechanisms of Enhancer Hijacking in Medulloblastoma (2018) [+] The Role of Protein Kinases in NRF2-driven Lung Squamous Cell Carcinoma (2018) [+] Epigenetic mechanisms of transcriptional activation of a novel oncogenic ALK variant in cancer (2018) [+] Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells (2018) [+] Phenotype Interactions in SCLC Development and Detection (2018) [+] Investigating the metastatic drive in pancreas cancer (2018) [+] Genomic and Functional Identification of Chemotherapy Resistance Mechanisms in Small Cell Lung Cancer (2018) [+] New models and therapeutic approaches in alveolar rhabdomyosarcoma (2018) [+] Exploring Collateral Lethality for Development of Cancer Therapeutics (2018) [+] Tissue-specific genetic interactions in cancer (2018) [+] (PQ4) - Tools for simultaneous disruption of multiple epigenetically silenced genes for studying their roles in tumorigenesis using ex vivo human and mouse colon organoid and in vivo mouse models (2018) [+] UBAP2, A New Molecule in Pancreatic Cancer Progression (2018) [+] Molecular Mechanisms of Large Oncosome-Induced Prostate Cancer Progression and Metastasis (2019) [+] Targeting aberrant enhancer landscapes in pancreatic cancer (2019) [+] Targeting SNP BRMS1v2 A273V/A273V to reduce metastases in lung adenocarcinoma (2019) [+] Exploiting POU2F3 addiction in the tuft cell variant of small cell lung cancer (2019) [+] Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer (2019) [+] STAT3 is a Critical Regulator of Tumor Cell Plasticity (2019) [+] Cellular Epigenetic Heterogeneity as a Predeterminant of Malignant Transformation Potential (2019) [+] Elucidating and targeting subtype-specific driver in pancreatic cancer (2019) [+] Defining Transcriptional Regulators of Melanoma Initiation using Zebrafish (2019) [+] The origins of metabolic reprogramming in prostate cancer (2019) [+] Elucidating the Role of MALAT1 Somatic Driver Mutations in Colorectal Cancer (2019) [+] Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cells (2019) [+] Defining tumor cell and host adaptations in cancer progression (2019) [+] Exploring the epigenetic control of pancreatic cancer subtypes (2019) [+] Lineage heterogeneity and plasticity in lung cancer (2019) [+]
	L1D342 (1.3)	L1T13 (11%): nanoparticles (3%), endosomal (2%), delivery_platform (2%), sirnas (2%), nanoparticle-based (2%) L1T167 (8%): cachexia (12%), cancer_cachexia (11%), muscle_wasting (10%), muscle (9%), skeletal_muscle (9%) L1T78 (7%): micrornas (5%), muscle_stem_cells (4%), mirna (3%), aberrantly-expressed (3%), satellite_cells (3%) L1T144 (5%): metastasis (12%), metastatic (10%) L1T137 (4%): promotes (4%), prevents (3%), we_find (3%), suppresses (3%), found_that (3%) L1T50 (4%): cancer (3%), significant (2%), our (1%) L1T15 (4%): tnbc (5%), cancer-related_deaths (5%), shorter_survival (4%), triple_negative_breast_cancer (3%), currently_there_are (3%) L1T184 (4%): therapeutics (15%), targeting (10%) L1T49 (3%): mouse_models (5%), poor_prognosis (5%), axis (4%), knockdown (3%), can_be_targeted (3%) L1T177 (3%): show_that (8%), not_only (7%), but_also (7%), target (7%), novel (7%)	ACTIVATION SPECIFIC C ERBB 2 DETECTION IN BREAST CANCER (1992) [+] LIPIDS AND B2-ADRENERGIC STIMULATION IN CANCER CACHEXIA (1993) [+] TARGETED GENE DELIVERY FOR LUNG CANCER GENE THERAPY (1995) [+] CATIONIC LIPID/P53 GENE THERAPY IN LUNG CANCER PATIENTS (2000) [+] Identifying Genes that Cause Lung Cancer to Progress (2003) [+] RNAi-Based Therapy of Hepatocellular Carcinoma (2005) [+] INHIBITING SURFACE HSP90 TO LIMIT METASTASIS (2005) [+] Tumor-Targeting Oligonucleotides (2006) [+] Transposon Mediated Gene Therapy for Colorectal Cancer (2007) [+] Cachexia in ApcMin/+ mice: The role of IL-6 (2008) [+] Roles of TIP-1 in Cancer Radiotherapy (2008) [+] Nutrition and Anabolic Interventions in Cancer Cachexia (2008) [+] Engineering Triggered Nanomechanical Therapeutics (2009) [+] Protein-DNA Drug Carriers for Tumor Targeting (2009) [+] Identification of Novel Cancer Selective Compounds in 3D Tumor Organoid Assays (2009) [+] Manipulation of STAT3 Signaling for Muscle Preservation in Cancer Cachexia (2010) [+] Targeting Pancreatic Cancer Using Peptide Chemistry: From Bench to Bedside (2010) [+] MicroRNA Expression Profiling Circuits for Detection and Destruction of Cancer (2011) [+] Imaging and targeting metastatic disease (2012) [+] Breast microcalcifications and their role in breast cancer bone metastasis (2012) [+] Development of anti-CXCR4 compounds to block breast cancer metastasis (2012) [+] (PQD6) Muscle stem cells and cancer cachexia (2013) [+] STRESS UNDERMINES IMMUNE STIMULATION: MECHANISMS & BIOLOGICAL SIGNIFICANCE (2013) [+] Regulation of molecular thermal ablative resistance in hepatocellular carcinoma (2013) [+] PQB-3: Discovery and validation of the driving mediators of cancer cachexia (2014) [+] Exploiting the Tumor Microenvironment to Block Breast Cancer Bone Metastasis (2014) [+] (PQD6)The Role of Immune Homeostasis in Protection from Cancer Cachexia (2014) [+] Aptamer-siRNA gene knockdown to treat epithelial triple negative breast cancer (2015) [+] PQB3: Mechanisms & Targeting of Sonic Hedgehog Signaling in Muscle Wasting of Cancer Cachexia (2015) [+] RNA Therapeutics for Targeted Treatment of Colon Cancer (2015) [+] miRNAs:Safe and effective therapeutic adjuvants for treating drug resistant TNBC (2015) [+] Cellular Basis for Radiation induced acceleration of sarcopenia in juvenile cancer survivors (2017) [+] Therapeutic miRNA Modulation of Hepatocellular Carcinoma Using Ultrasound Guided Drug Delivery (2017) [+] Targeting the Metabolic Basis of Cachexia in Pancreatic Cancer (2017) [+] Significance of Inhibiting Long Non-coding RNAs in Advanced Breast Cancer (2017) [+] Development of a novel therapeutic agent that exploits specific vulnerabilities in claudin low breast cancer (2017) [+] (11) Diet Modification to Augment Radiation for Breast Cancer Brain Metastases (2018) [+] Therapy for Metastatic breast cancer based on micro RNA silencing (2018) [+] Ligand-mediated, vehicle-free delivery of small RNAs (2018) [+] Novel approach to attenuate small cell lung cancer growth and metastasis (2018) [+] Clinical significance and mechanism of action of exosomal microRNAs in Neuroblastoma chemoresistance. (2018) [+] IRAK4 As a Novel Immunotherapeutic Target in Pancreatic Ductal Adenocarcinoma (2018) [+] Smart nanoparticles regulating oncogenic IncRNA for breast cancer therapy (2019) [+] Multifunctional siRNA/antibody nanocarriers to treat metastatic triple-negative breast cancer (2019) [+] Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia (2019) [+] Whitlockite nanoparticle-based immunotherapy for bone metastasis (2019) [+] Exploiting the Twist1 network in cancer cachexia (2019) [+] Modulating dietary zinc to prevent cachexia and improve survival in cancer (2019) [+] Parathyroid Tumor Clonal Status as a Biomarker in Primary Hyperparathyroidism (2019) [+]
	L1D378 (1.5)	L1T56 (18%): braf (5%) L1T45 (9%): signaling (7%), pi3k (3%) L1T99 (7%): targeted_therapies (6%), druggable (4%) L1T49 (6%): pharmacological_inhibition (5%), therapeutic_target (4%), therapeutic_strategies (3%), driven_by (3%), highly_aggressive (3%) L1T15 (4%): therapies (4%), upfront (3%), targeted_therapeutics (3%), disease_progression (3%), effective_therapies (3%) L1T194 (4%): therapy (13%), combination_with (8%) L1T117 (4%): resistance (19%), acquired_resistance (13%), resistant (9%)	Apoptosis in Melanoma Progression and Chemoresistance (2004) [+] Identifying determinants of chemotherapeutic response in vivo (2007) [+] Determinants of signaling network regulation in combinatorial targeted therapies (2008) [+] Targeting BRAF and MEK in tumors with BRAF and RAS mutations. (2008) [+] Akt3 Signaling as a Therapeutic Target (2008) [+] Validating Syk as a Target for AML Therapy (2009) [+] Proteomic biomarkers of ALK+ lymphoma (2010) [+] Combination Therapy that Targets Glutamate Signaling in Melanoma (2010) [+] The ALK receptor tyrosine kinase as a therapeutic target in neuroblastoma (2011) [+] The Role of BRAF Mutation in Thyroid Cancer Invasion (2011) [+] MAP Kinase Signaling in Lymphoma: A Novel Therapeutic Paradigm (2012) [+] Targeting the LKB1-AMPK PATHWAY in Melanoma: Mechanism and Preclinical Evaluation (2012) [+] FOXD3 up-regulation and ERBB3 signaling as an adaptive response to RAF inhibitors (2012) [+] Improved therapeutic approaches for hematological disorder treated with tyrosine (2012) [+] Targeting Focal Adhesion Kinase in Thyroid Cancer (2012) [+] A role for c-Abl/Arg in melanoma progression (2012) [+] Stat3 Signaling in Pancreas Cancer (2012) [+] PAK Kinases Regulate Melanoma Chemoresistance and Metastasis (2013) [+] Targeting Translation Dependence in Colorectal Cancer Progression (2013) [+] Inhibiting VHL-positive kidney cancer (2013) [+] Negative feedback signaling in tyrosine kinase-driven leukemia (2013) [+] (PQD1) Response and Resistance to Inhibitors of Ras Effectors in Blood Cancers (2013) [+] PDK1 as a Novel Target in Melanoma (2013) [+] Targeting the p110beta Isoform of PI3 Kinase in Pten Null Tumors (2013) [+] Mechanisms of resistance to ponatinib therapy in chronic myeloid leukemia (2014) [+] Towards The Chemotherapy-Free Treatment of Follicular Lymphoma (2014) [+] ALK Rearrangements in Aggressive Thyroid Cancer (2014) [+] (PQC2) Plasticity Of The.PI3K Network In Early Dormancy (2014) [+] Targeted therapies in mutant BRAF melanoma (2014) [+] Mechanisms of PAK1 activation, signaling and tumor resistance (2014) [+] A New Treatment Paradigm for ALK-Driven Cancers Exploiting Oncogene Overdose (2014) [+] Unraveling resistance to PI3K-alpha inhibitors in breast cancer (2015) [+] REGULATION OF UVEAL MELANOMA CELL FATE BY THE PKC PATHWAY VIA MITF (2015) [+] Mutant BRAF-regulated transcription factors in melanoma progression (2015) [+] Targeting the cytokine circuitry of KRAS-driven lung cancer (2015) [+] Dual targeting of XPO1 and BTK in B cell malignancies (2015) [+] gp130 as a novel therapeutic target in ovarian cancer (2015) [+] Epigenetic Gene Regulation by JAK1 Kinase in Diffuse Large B-Cell Lymphoma (2015) [+] Phosphatase activation as therapeutic strategy for Chronic lymphocyic leukemia (2015) [+] Mechanisms of resistance to ALK inhibitors in ALK-rearranged lymphoma (2015) [+] Mechanistic studies of cancer cell adaptive response to PI3K/AKT inhibition (2015) [+] Exploiting proteotoxic stress in therapy-refractory HER2+ breast cancers (2015) [+] Selectively Targeting Oncogenic NRAS in Cancer (2015) [+] Harnessing beneficial off-target effects of kinase inhibitors in lung cancer (2015) [+] RIP1/3 Kinases as New Targets in Malignant Mesothelioma (2015) [+] Molecular mechanisms of BRAF inhibitor induced UPR and autophagy (2015) [+] Natural product-based modulators of 4E-BP1 phosphorylation (2016) [+] Therapeutic resistance and tumor heterogeneity in BRAF mutant colorectal cancer (2016) [+] The role of EGFR as a mechanism of therapeutic resistance in gene fusion positive lung cancer. (2016) [+] Targeting AKT-Mutant Human Cancers (2016) [+] Therapeutic efficacy of the CRL inhibitor MLN4924 in NF2 mutant mesothelioma (2016) [+] Molecular and Cellular Mechanisms of Resistance to mTORC1 Inhibition in the Skin (2016) [+] Development of Quinoxaline Based IKKbeta Inhibitors for Kras Driven Cancers (2016) [+] Nucleoporin NUP205-driven Novel Pathway in Melanoma Tumor Growth and Metastasis (2016) [+] Selectively targeting apoptosis in PIK3CA mutant colorectal cancers (2016) [+] The role of PTEN feedback mechanism in cancer (2016) [+] A NOVEL DRUGGABLE GENETIC VULNERABILITY PATHWAY IN MELANOMA (2016) [+] Kinase Inhibition in Kidney Cancer (2016) [+] Role of MAST1 kinase in cisplatin resistant cancers (2017) [+] Elucidating and Leveraging the mTOR Negative Feedback Pathway in Breast Cancer (2017) [+] Targeting BPTF in the Therapy of BRAF-mutant Melanoma (2017) [+] Mechanism-based strategies to target oncogenic BRAF signaling (2017) [+] Targeting TGFbeta/PDK4 to Overcome Drug Resistance in Colorectal Cancer (2017) [+] Inhibition of brain metastasis by blocking MAPK12 driver kinase functions (2017) [+] Optimizing biologically-based rational polytherapy in ALK+ lung cancer (2017) [+] Targeting bidirectional signaling in lung stroma and cancer cells (2017) [+] Targeting TERT in Melanoma (2017) [+] Experimental Therapeutics by targeting Spleen Tyrosine Kinase (2017) [+] Targeting the kinome in K-ras driven colorectal cancers (2017) [+] Development of SHP2 inhibitors for targeted anti-cancer therapy (2017) [+] Characterization of YAP as a rational companion target in lung cancer (2017) [+] Development of a Dual and Selective Small Molecule Inhibitor of EGFR and PI3 Kinase to Treat BRAF Mutant Colorectal Cancer (2018) [+] A druggable dependency in low-MITF/high-AXL melanoma: preclinical efficacy and mechanism of action in a key treatment-resistant subclass. (2018) [+] Dissecting KRAS oncoprotein signaling with allele specific inhibitors (2018) [+] Translation addiction and targeting in colon cancer (2018) [+] Targeting Wnt-dependent colorectal cancer (2018) [+] Targeting the Rac1 signaling pathway in malignant melanoma (2018) [+] Targeting FAK and Src in thyroid cancer (2018) [+] Understanding tumor addiction to TRK fusions and sensitivity to TRK inhibition (2018) [+] GMPS-GMPR axis melanoma progression and therapy. (2018) [+] Tailoring Therapy to Pancreatic Cancer Subtypes (2018) [+] Targeting Abl kinases in BRAF-driven melanomas (2018) [+] Exploiting the distinct genomics and signaling of colorectal cancers to effectively target ERK (2019) [+] Targeting Drug-Resistant Cancer Stem Cell Niches of Gastrointestinal Stromal Tumor (2019) [+] Development of BRAF Dimer Inhibitors to Treat Drug Resistant Melanoma (2019) [+] G alpha-q/11 Signaling and Inhibition in Ocular Melanoma (2019) [+] Combating Resistance of Pancreatic Cancer with a First-in-Class Dual Targeted PI3K/EGFR Inhibitor (2019) [+] Identifying and targeting evolutionary trajectories in cancer (2019) [+] Targeting the Unfolded Protein Response in Leukemia Biology and Chemotherapy Resistance (2019) [+] Energy reprogramming-regulated oncopathways and drug resistance in triple negative breast cancer (2019) [+] Investigation of CXCR7 signaling in EGFR TKI resistant NSCLC (2019) [+] Targeting Hippo pathway in melanoma (2019) [+] Molecular mechanisms and therapeutic targeting of PI3K-p110beta/PTEN signaling in breast cancer and cancer immunity (2019) [+]
	L1D380 (1.4)	L1T82 (29%): immunotherapy (5%), immune (4%), immunotherapies (2%) L1T50 (7%): however (2%), approaches (1%), cancer (1%), ici (1%), but (1%) L1T99 (6%): landscape (5%), predictive_biomarkers (4%), transcriptome (3%), mutational_burden (3%) L1T101 (5%): t_cells (9%) L1T33 (3%): non-responders (5%), comprehensive (3%), have_revolutionized (3%), overarching_goal (3%), integrated (3%)	Analysis of Patient Tumor Responses to Apo2L/TRAIL (2006) [+] Host's Genes that Control Lymphocyte Infiltration of Tumors (2008) [+] Clinical Impact of B7-H Immune Cell Coregulators in Renal Cell Carcinoma (2009) [+] Role of autophagy in tumor cell death (2010) [+] Discovery and Validation of Tumor Immunoevasion Mechanisms (2011) [+] Complementary Signaling Pathways In Hodgkin Lymphoma and Related Malignancies (2011) [+] Proinflammatory T Regulatory Cells in Colon Cancer (2012) [+] Strategies for Distinguishing Success in Immunotherapy Treatments (PQ20) (2012) [+] Rational Sequencing of PD-1 and CTLA-4 Antibodies in Metastatic Melanoma (2013) [+] (PQA2) MAMMALIAN REGENERATION, HIGH FAT DIETS, AND BREAST CANCER: A COMMON LINK? (2013) [+] The B7x pathway in the tumor microenvironment (2014) [+] Obesity affects immunity to kidney cancer (2014) [+] Engineering alpha fetoprotein and glypican-3 to develop hepatoma (HCC) vaccines (2014) [+] Biomarkers and Resistance Mechanisms in Melanoma T-cell Therapy (2014) [+] Targeting tumor endothelium for cancer surveillance and immunotherapy (2015) [+] Response and Acquired Resistance to PD-1 Blockade (2015) [+] Credentialing Mouse Models for Immune System Therapy Research (2015) [+] DEVELOPMENT OF GENOMICS BASED PERSONALIZED CANCER IMMUNOTHERAPY (2015) [+] IDO2 Targeting in Pancreatic Cancer (2015) [+] Applicability of Mouse Breast Cancer Models to Tumor-Immune Network Investigation (2015) [+] Congenic Mouse Medels of Melanoma for the Characterization of Tumor Immune Responses (2016) [+] Reprogramming the tumor microenvironment via self-amplified RNA (SafeR) circuits (2016) [+] Integrative systems approach to identify local oncogenic modulation of the IL12 axis (2016) [+] (PQ7) Quantitative in vivo optical imaging of tumor heterogeneity (2016) [+] Improving Diagnosis and Management of Cancer Immunotherapy-Induced Hypophysitis (2016) [+] Integrated Discovery Pipeline for Tumor Neoantigens (2016) [+] Germline and somatic variants associated with melanoma immunophenotype (2016) [+] (PQ3) The role of damaged DNA in inter-individual variation of tumor immunity (2016) [+] Leukemia Specific Splice Isoforms as Neo-Antigens for T-Cell Immunotherapy (2016) [+] Correlates of antitumor immunity in colorectal cancers and anti PD1 therapy (2016) [+] (PQ5) Investigation of intertumoral and intratumoral heterogeneity of mitochondrial apoptotic sensitivity (2016) [+] Towards True Precision Oncology: Validation of a Comprehensively Humanized, Autologous Mouse Model (2017) [+] (PQ3) Cellular and Molecular Mechanisms Driving Myeloid Compartment Variation in Human Triple Negative Breast Cancer (2017) [+] Spatiotemporal regulation of T cell fate decisions in cancer (2017) [+] Elucidating genetics of response to immune checkpoint blockade in lung cancer (2017) [+] Development of an autologous humanized model of melanoma exploring human thymic education capacity (2017) [+] Linking the microbiome and immune-checkpoint in melanoma by RNF5 (2017) [+] Coordinating tumor differentiation and immune suppression with the metabolic state and treatment outcome (2017) [+] (PQ3) Disruption of immune surveillance by aneuploidy and aberrant MHCII expression (2017) [+] Developing a Human in Mouse Cancer Model with a Completely Humanized Stroma (2017) [+] Imaging tumor associated macrophage (TAM) function (2017) [+] Immune epigenetic biomarkers of survival in glioma epidemiology (2017) [+] Molecular and immune drivers of immunotherapy responsiveness in prostate cancer (2018) [+] Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors (2018) [+] (PQ10) Enhancing responses to immune checkpoint blockade in melanoma via modulation of the microbiome (2018) [+] Mechanisms of Tumor Derived Neutrophil Induced Apoptosis in Lymphocytes (2018) [+] (PQ2) PD-L1/PD-1 signals in aged hosts undergoing cancer immunotherapy (2018) [+] Macrophage phenotype polarization in clinical neoplasia (2018) [+] Targeting alternative splicing for TCR discovery in small cell carcinomas (2018) [+] Stimulating Neo-Antigen Specific T Cell Responses in Head and Neck Cancers (2018) [+] Advancing the translatability of mouse models for cancer immunotherapy (2018) [+] Directing the metabolic fate of CAR T cells (2018) [+] The Role of Epithelial-Mesenchymal Transition in Re-Wiring KRAS Mutant Lung Cancer (2018) [+] Single Cell Genome-Wide Myeloid Response Profiling in Immunotherapy (2018) [+] (8) Genomic determinants of the T-cell regulome in immune checkpoint blockade (2018) [+] Fecal Microbiota Transplant and PD-1 blockade in Melanoma (2018) [+] (PQ8) Predicting immune-related toxicity in the adjuvant melanoma setting with checkpoint inhibition (2018) [+] High-throughput in vivo genetics for immunotherapy target discovery (2018) [+] Tumor-intrinsic signaling pathways restrict anti-tumor immunity in hepatocellular carcinoma (2018) [+] Determinants of prostate cancer sensitivity to PD-1 blockade (2018) [+] In Situ characterization and manipulation of tumor immune cell metabolomics using implantable microdevices (2018) [+] Cassette exons in neoplastic pro-B-cells: implications for immunotherapy (2018) [+] Harnessing protease activity for predictive monitoring of cancer immunotherapy (2019) [+] Mechanisms of Exosome Driven Immunoregulation of Cancer Progression (2019) [+] Deciphering the Achilles Heel of Cancer Immunotherapy (2019) [+] Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors (2019) [+] Defining the features of T cell response to tumor and self-antigens as predictors of response to checkpoint therapy (2019) [+] Reverse-engineering precision liver cancer chemoprevention (2019) [+] Defining how obesity shapes immunity and the success of cancer immunotherapy (2019) [+] Phase 1/2 Study of Modern Immunotherapy in BCG-Relapsing Urothelial Carcinoma of the Bladder - (ADAPT-BLADDER) (2019) [+] Regulators of Cancer Immunotherapy Response (2019) [+] Cutaneous T cell lymphoma: a paradigm for dissecting susceptibility and resistance to checkpoint inhibition therapy (2019) [+] Linking insertional mutagenesis and cell function to improve CAR T cell therapy (2019) [+] Defining mechanisms of immunotherapy resistance in head and neck squamous cell carcinomas (2019) [+] Polymerase-mediated ultramutagenesis and carcinogenesis in mice (2019) [+] Identification of Druggable Targets to Complement Melanoma Therapy (2019) [+] Targeting epigenetic heterogeneity to improve lung cancer immunotherapy response (2019) [+] Targeting adrenergic stress pathways to Increase tumor sensitivity to radiation and promote development of an anti-tumor immune response (2019) [+] Single Cell Methods for Bioeffector Discovery and Analysis (2019) [+] (PQ8) Patient- and tumor-specific biomarkers and mechanisms that predict irAEs resulting from checkpoint inhibition (2019) [+] The molecular and immune evolution in the progression of lung neoplasia to invasive adenocarcinoma (2019) [+] Functional Activation of Low Affinity TILs (2019) [+] Robust Immuno-prevention Strategies for High-Risk Oral Epithelial Dysplasia (2019) [+] Understanding and Overcoming Resistance to Cancer Immunotherapy Due to Defective Antigen Presentation (2019) [+] Defining the impact of intra-tumoral morphologic, immune and mutational heterogeneity in urothelial carcinoma (2019) [+]
	L1D316 (1.4)	L1T5 (15%): oncosome-associated (0%), indigenously (0%), onco-pig (0%), gcp1 (0%), digicount (0%) L1T10 (8%): ctcs (2%), cystic (2%), circulating_tumor (2%), nomogram (2%), ipmns (2%) L1T121 (8%): pancreatic_cancer (8%), pancreatic (6%), ipmn (4%) L1T113 (7%): biopsies (5%), indolent (5%), grading (4%), gleason_score (4%), gleason (4%) L1T14 (5%): imaging (6%) L1T97 (5%): detection (10%), early_detection (9%), detect (7%), biopsy (7%), diagnosis (6%) L1T158 (3%): assessment (5%), screening (4%), oncology (3%), management (3%), team (3%)	BIOCHEMICAL STUDIES ON OPTIMAL CORNEAL PRESERVATION (1987) [+] NEW MARKERS FOR DETCTION &EVALUATION OF BLADDER TUMORS (1988) [+] ACTIVATION-SPECIFIC C-ERBB-2 DETECTION IN BREAST CANCER (1994) [+] MRI TO ASSESS RESPONSE OF BREAST CANCER BONE METASTASES (1995) [+] BIOMORPHOMETRY OF HUMAN PROSTATIC CANCER (1996) [+] ANATOMIC AND BIOLOGIC STAGING OF BREAST DISEASE WITH MRI (1997) [+] Diagnosis of IM Nodal Metastases in Breast Cancer (2001) [+] Optical Spectroscopy of Ovarian Cancer (2003) [+] EPS Markers in the Early Detection of Prostate Cancer (2004) [+] Pharmacodynamics of Gemcitabine by MRS in Pancreatic CA (2005) [+] High-speed reliable detection of cancer cells in blood (2006) [+] Predicting Metastasis in Melanoma (2006) [+] "Molecular Signatures of Lethal and Indolent Prostate Cancer" (2006) [+] Markers of Early Pancreatic Cancer (2006) [+] Towards a non-invasive molecular test for bladder cancer (2007) [+] Characterizing the Evolution of Pre-malignant Tissues at High Risk for Malignancy (2008) [+] Molecular Markers for the Diagnosis of Pancreatic Cancer (2008) [+] Aptamer Based Technology for Molecular Analysis of Leukemia (2008) [+] Genetic progression of pancreatic mucinous cystic neoplasms to invasive carcinoma (2009) [+] Circulating Tumor Cell Capture &Analysis in a Multi-Center Prostate Cancer Trial (2009) [+] Infrared microscopy for a systems approach to prostate pathology (2010) [+] PET Imaging of KRAS2 Activation to Guide EGFR Targeting in Cancer Therapy (2010) [+] DCE MRI to Improve Prostate Cancer Identification and Characterization (2010) [+] A bifunctional nanomedicine for both specific imaging and targeting therapy of an (2010) [+] Oncopigs as a better model for human cancer (2010) [+] Comprehensive Prostate Cancer Characterization by Genomic and Transcriptomic Prof (2011) [+] External validation of GEMCaP, a prognostic DNA biomarker set for CaP recurrence (2011) [+] Novel molecular imaging approaches to monitor gene and cell-based therapies (2011) [+] VPAC1 Recpetor-Targeted PET Imaging of Prostate Cancer (2012) [+] Single-cell phenotyping for therapeutic stratification in pancreatic cancer (2012) [+] Breast Cancer Bone Metastasis (2013) [+] Using Markers to Improve Pancreatic Cancer Screening (2013) [+] [PQC-3] A Metabolic Pathway Activation Marker for Prostate Cancer Prognosis (2014) [+] Biomarker validation for intraductal papillary mucinous neoplasms of the pancreas (2014) [+] Validating a mouse model of ovarian cancer for early detection through imaging (2015) [+] Labeling nanobodies with 18F residualizing labels for HER2 specific PET imaging (2015) [+] Employing mouse models to translate early detection of pancreas cancer (2015) [+] Validation of pancreatic cancer biomarkers in large prospective cohorts (2015) [+] Ultrasound Molecular Imaging to Assess Therapeutic Response (2015) [+] Risk-stratification of Prostate Cancers via Field Carcinogenesis Nanocytology (2015) [+] First in-human PET imaging studies of NIS reporter [18F]BF4 (2016) [+] Histologic and Immunohistochemical Biomarkers for Heavily Treated Metastatic Prostate Cancer. (2016) [+] Optimizing Ultrasound Enhanced Delivery of Therapeutics (2016) [+] Early detection of ovarian cancer by serum marker and targeted ultrasound imaging (2016) [+] Developing silastic-silicone for the local delivery of hormonal therapy to prevent and treat breast cancer (2017) [+] A blood test to identify prostate cancer patients at risk for visceral metastasis (2017) [+] The Development And Progression Of IPMN To PDA In The Context Of Inactivated Activin Signaling (2017) [+] Label free microfluidic isolation, characterization and ex vivo expansion of CTCs (2017) [+] Reconstituting human pancreatic cancer development for translational research (2017) [+] High-throughput palmitoyl-proteomics profiling of extracellular vesicles for identification of biomarkers for early detection of clinically significant prostate cancer (2017) [+] Hypoxia-derived molecular MSI signatures to predict breast cancer outcome (2017) [+] Translational Applications in an Animal Model of Pancreatic Cystic Neoplasm and Cancer (2018) [+] Non-invasive Quantification of Dose-Exposure-Response of PD-L1 Therapeutics at the Tumor (2018) [+] Development and Application of a Porcine Model of Pancreatic Cancer (2018) [+] Multi-site Gastrointestinal Cancer Detection by Stool DNA Methylation (2018) [+] Molecular Digital CytoImaging for Leukemia Drug Screening (2018) [+] Tumor immune and glycan biomarkers for progressive prostate cancer (2018) [+] Using Radiogenomics to Noninvasively Predict the Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Uncover Hidden Biology (2019) [+] Imaging and circulating DNA markers to assess early response and predict treatment failure patterns in lung cancer (2019) [+] PRedictiOn Algorithms for the DeTECTion of Early Stage Pancreatic Cancer (PRO-TECT) (2019) [+] Monitoring neoadjuvant chemotherapy of breast cancer using 3D subharmonic aided pressure estimation (2019) [+] MRI Imaging and Biomarkers for Early Detection of Aggressive Prostate Cancer (2019) [+] Hyperpolarized C-13 MRI for Early Detection of Aggressive Prostate Cancer in Active Surveillance Patients (2019) [+] Real time fine needle assessment of architectural heterogeneity in prostate cancer (2019) [+] Development and Validation of Prognostic Radiomic Markers of Response and Recurrence for Patients with Colorectal Liver Metastases (2019) [+] Pilot study of an implantable microdevice to test multiple drug responses in prostate cancer patients (2019) [+]
	L1D362 (1.4)	L1T5 (9%): ca-dinucleotide (1%), aneusomy (1%), event-free (1%), 5x109 (1%), mirna-cancer (1%) L1T82 (6%): immune (8%), immunotherapy (4%) L1T58 (5%): overall_survival (8%) L1T127 (5%): genotype (5%), genetic_variation (5%), genetic_variants (5%), snps (5%), genetic_factors (3%) L1T129 (4%): prognosis (15%), prognostic (10%) L1T50 (4%): we (2%), context (1%), our (1%), has_focused_on (1%), we_propose (1%) L1T10 (4%): signatures (4%), immune_profiles (3%), molecular_signatures (2%), multiplex (2%), circulating_tumor (2%) L1T188 (3%): predict (17%), biomarkers (15%) L1T149 (3%): non-hodgkin_lymphoma_nhl (5%), nhl (5%), leukemia_b-cll (5%), diffuse_large_b-cell_lymphoma (5%), chronic_lymphocytic (5%) L1T150 (3%): survival (24%), we_hypothesize_that (13%) L1T101 (3%): immune_response (17%) L1T136 (3%): patients (23%), outcome (15%), patients_with (12%)	PROGNOSTIC INDICATORS IN LOCALIZED COLON CANCER (1997) [+] DETERMINANTS OF CLINICAL OUTCOME/TOXICITY IN HISPANICS (1999) [+] Genetic Determinants of Lung Cancer Survival (2001) [+] B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSION (2001) [+] Immunogenetics of Non-Hodgkin Lymphoma Survival (2002) [+] Pharmacogenetics: Breast Cancer Treatment and Prognosis (2003) [+] Prognostic Molecular Markers of Colorectal Cancer (2003) [+] Stress, the Immune System and Basal Cell Carcinoma (2005) [+] Isolation of human tumor cells in dormant cancer (2005) [+] Pharmacogenetics of Hormonal Therapy for Breast Cancer (2006) [+] Surgery and the Mechanisms of Lymph Node Metastases in Cutaneous Melanoma (2007) [+] Breast Cancer Survival: Lifestyle and Genetic Determinants (2007) [+] Inflammation Pathways in Breast Cancer (2007) [+] Regulation of SULT1A1 in Human Breast (2008) [+] RRM1 in the Management of Lung Cancer (2008) [+] Regulatory T Cell Function in Ovarian Cancer (2009) [+] Molecular Epidemiology of non-Hodgkin Lymphoma Survival (2009) [+] Role of the BCR in B Cell Chronic Lymphocytic Leukemia (2009) [+] Effects of Low Dose CT Radiation on Lung Tumorigenesis (2009) [+] Biobehavioral Influences and the Ovarian Tumor Microenvironment (2009) [+] Immune dysregulation by psychosocial distress (2010) [+] Molecular epidemiology/functional analysis of microRNAs in Non-Hodgkin's lymphoma (2011) [+] Molecular biomarkers of airway and lung linking COPD and Lung Cancer (2011) [+] Molecular epidemiology of non-Hodgkin lymphoma prognosis and prevention (2012) [+] Development of Breast Cancer Risk Model Based on Estrogen Metabolomics (2012) [+] Mitochondrial DNA and Ovarian Cancer Risk and Survival (2012) [+] New and integrated perspectives on modification of tamoxifen effectiveness (2013) [+] Epigenetic miRNA, SNP Signatures, and their Functions in Lung Cancer Outcomes (2014) [+] Novel immunological biomarkers ovarian cancer prognosis (2015) [+] Predicting clinical outcome in individuals with small CLL B cell clones (2015) [+] The Epidemiology of Immune Responses in Colorectal Cancer (2015) [+] Host factors, tumor microenvironment and survival in a multiethnic study of Hodgkin lymphoma patients (2016) [+] Prospective immune profiling using methylation markers and pancreatic cancer risk (2016) [+] Biological implications of breast cancer protective variants in Latin American women with high Indigenous American ancestry (2016) [+] Modulation of host intrinsic immunity to reduce prostate cancer disparity (2016) [+] HIV induced anti-cancer HERV immunity in prostate, breast and colon cancers (2016) [+] (PQ3) Immune epigenetic biomarkers of bladder cancer outcomes (2017) [+] A model for predicting response to PD-1 inhibitors in NSCLC (2017) [+] Immune biological differences between Triple Negative Breast Cancer in African American and non-African American women and potential immunotherapy opportunities to improve treatment outcome (2017) [+] Vitamin D and Follicular Lymphoma (2017) [+] Evaluating the protective effect of a tissue selective estrogen complex (TSEC) in women with newly diagnosed ductal carcinoma in situ (2017) [+] Comprehensive characterization of prostate stromal gene expression and association with lethal prostate cancer (2018) [+] (8) Genetics of Immune Related Adverse Events and Response to Immunotherapy (2018) [+] Nrf2, immune cells and lung cancer (2019) [+] The immune contexture of colorectal adenomas and serrated polyps (2019) [+] (PQ11) Immune modulatory effects of white button mushroom in prostate cancer - A translational research (2019) [+] A Noninvasive Integrated Genomic Approach for Early Cancer Detection and Risk Stratification after Transplantation (2019) [+] Aggressive prostate cancer of African Americans is correlated with regulation of Immunoregulatory Genes in stroma (2019) [+]
	L1D370 (1.4)	L1T103 (23%): parp_inhibitors (5%), homologous_recombination_hr (3%), parp_inhibitor (3%), parp (2%) L1T1 (9%): dna_repair (11%), dna_damage (10%), repair (6%) L1T99 (5%): vulnerabilities (5%), high-grade_serous_ovarian_cancer (4%), targeted_therapies (3%), hgsoc (3%), chemoresistant (3%) L1T194 (4%): therapy (13%), chemotherapy (11%) L1T117 (4%): sensitize (11%), cisplatin (11%), resistance (10%), sensitizes (8%) L1T107 (4%): efficacy (15%), combination (9%) L1T15 (3%): therapies (6%), xenograft_models (4%), triple_negative_breast_cancer (3%)	NOVEL DOUBLE STRAND BREAK PRODUCING COMPOUNDS (1999) [+] Biomodulation of anticancer drugs targeting DNA (2007) [+] NF-kB1-p50 in the response to DNA alkylation damage (2009) [+] Overcoming therapy resistance in GBM (2009) [+] Mechanism-Based Use of Chk1 Inhibitors in Pancreas Cancer (2010) [+] Novel approaches to enhance tumor cell cytotoxicity of alkylating agents (2010) [+] Targeting Somatic Homologous Recombination in Solid Tumors (2010) [+] Targeting the cell cycle in triple negative breast cancer (2011) [+] Targeting the ATR pathway in p53-deficient cancers (2011) [+] Improving etoposide treatment of Ewing's sarcoma (2011) [+] Selective Sensitization of Pancreatic Cancer to Therapy by Chk1 and PARP1 Inhibit (2012) [+] Studies of DNA interstrand crosslink repair to improve crosslinking drug therapie (2012) [+] Characterizing and Targeting CHD4 Deficiency in Endometrial Cancer (2013) [+] Targeting nucleotide excision repair in combination cancer therapy (2013) [+] Mechanisms of acquired temozolomide resistance in glioblastoma multiforme (2013) [+] Cell-Penetrating Anti-DNA Antibody for Radiosensitization and Cancer Therapy (2013) [+] HLTF gene silencing: a novel determinant of sensitivity to autophagy inhibition (2013) [+] The Regulation of Cisplatin resistance in ovarian cancer (2014) [+] Novel functions of Pyruvate kinase M2 in DNA double-strand break repair (2014) [+] Identifying Biomarkers of Cisplatin Resistance Mechanisms in Ovarian Cancer (2014) [+] MTDH regulates Fanconi anemia repair pathway to mediate drug resistance (2014) [+] Mechanisms of PARP Inhibitor Resistance in Ovarian Cancer (2015) [+] Targeting BRCA Deficient Cells for Killing (2015) [+] Tunable Microchip Sorting of BRCA1 Nuclear Assemblies (2015) [+] CDK12 in Ovarian Cancer (2016) [+] Mechanisms of radioresistance and strategies for radiosensitization in OCCC (2016) [+] Therapeutic strategies for targeting PARP1 in small cell lung cancer (2016) [+] PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM (2016) [+] Targeting Kinesin Family Member 15 for the Treatment of Cancer (2017) [+] Common genetically altered pathways as targets for therapy in pancreatic cancer (2017) [+] Isozyme-selective ALDH Inhibitors for Sensitizing Ovarian Cancer Stem-like Cells to Chemotherapy (2017) [+] Developing novel combination therapies for pancreatic cancer (2017) [+] Averting recurrent and resistant ovarian tumors (2017) [+] The structural function of ATR in development, oncogenesis and cancer therapy (2017) [+] Tumor-selective use of PARP inhibitors against NQO1+ nonsmall cell lung cancer (2017) [+] Rational Combination Therapy with PARP Inhibitors in Triple Negative Breast Cancer (2017) [+] Cell Cycle Blockade and Therapeutic Sensitization (2017) [+] Exploiting mitochondrial heteroplasmy for cancer chemotherapy (2017) [+] Exploiting WEE1/p53 synthetic lethality as a novel therapy in head and neck cancer (2017) [+] Investigating 53BP1 'dephosphorylation' as a critical determinant of PARP (2017) [+] Exploiting Mutant IDH1/2-induced Homologous Recombination Defects in Cancer (2017) [+] Targeting HuR to improve a synthetic lethal therapy for pancreatic cancer (2017) [+] Signature-guided therapy for mismatch repair defective cancers (2017) [+] Parp Function in Prostate Cancer (2017) [+] Mechanisms of tumorigenesis in Brg1 mutant lung cancer (2018) [+] The Inflammasome as a novel mediator and therapeutic target of GI syndrome (2018) [+] Tumor-selective radiosensitization of NSCLC using NQO1 bioactivatable drugs (2018) [+] A novel more effective genotoxic therapy for ovarian cancer (2018) [+] Mechanisms of targeting cellular self-renewal in glioblastoma (2018) [+] DNA repair alterations in metastatic prostate cancer: functional and therapeutic implications (2018) [+] Hedgehog/Gli1-targeted therapies to overcome ovarian cancer chemoresistance and disease recurrence (2018) [+] Target MDM2/MDMX for reducing normal tissue toxicity induced by chemotherapy (2019) [+] Optimizing PARP inhibitor therapy through novel approaches to resolve the molecular mechanisms of response (2019) [+] Inhibition of DNA double strand break repair in TNBC by nitro-fatty acids (2019) [+] RNA-Binding Proteins as Molecular Integrators that Control the Response of HGSOC to Ant-Cancer Therapies (2019) [+] Identify the Mechanisms of LMO2-Mediated Inhibition of Homologous Recombination and Establish PARP-Targeted Synthetic Lethality as a New Therapy for DLBCL (2019) [+] Novel role of APOBEC3 enzymes as key mediators of cisplatin sensitivity through aberrant processing of interstrand crosslinks (2019) [+] Establishing MAGE-A4/RAD18 as a novel cancer-specific chemotherapeutic target (2019) [+] Molecular mechanism and preclinical development of BETi and PARPi combination therapy (2019) [+] Pro-tumorigenic functions of human DNA polymerases eta and kappa during genome duplication under physiological replication stress conditions (2019) [+] Targeting DNA repair in KRAS mutated lung cancer by chemical screening (2019) [+] Inhibition of Translesion Synthesis as a Novel Strategy for Cancer Chemotherapy (2019) [+]
	L1D323 (1.4)	L1T96 (12%): esophageal_adenocarcinoma (4%), adenocarcinoma (3%), esophageal (3%), methylight (3%), dysplasia (2%) L1T108 (8%): methylation (9%), epigenetic_changes (6%), dna_methylation (5%) L1T129 (6%): markers (10%), dna_copy_number (6%) L1T188 (4%): biomarkers (18%), samples (15%), profiles (10%) L1T157 (4%): genomic (10%), genetic (10%), p16 (6%), genome-wide (6%), somatic (6%) L1T97 (4%): diagnosis (20%), detect (13%), detection (12%), early_detection (10%) L1T57 (3%): incident (3%), nested_case-control_study (3%), risk_factors (3%), cdkn2a_p16 (2%), analytic_approaches (2%) L1T58 (3%): wash (5%), anatomic_site (5%), patients_who (4%), ecog (4%), advanced_stage_disease (3%) L1T29 (3%): loh (7%), copy_number_changes (7%), array_cgh (5%), allelic_loss (4%), amplicons (4%) L1T141 (3%): disease (16%), identifying (15%), identify (14%), identified (9%), associated_with (8%)	BLADDER CANCER CHEMOPREVENTION (4HPR)--MOLECULAR STUDIES (1993) [+] P53--MARKER FOR ORAL CAVITY PREMALIGNANCY &CANCER RISK (1995) [+] ENVIRONMENTAL &GENETIC DETERMINANTS OF PROSTATE CANCER (1995) [+] GENETIC BIOMARKERS OF HUMAN SQUAMOUS CELL CARCINOMA (1995) [+] GENETIC ALTERATIONS IN GASTRIC CARCINOMAS (1995) [+] GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER (1996) [+] MOLECULAR CHANGES IN ORAL LESIONS OF CHEMICAL ETIOLOGY (1997) [+] MOLECULAR STUDIES OF ESOPHAGEAL ADENOCARCINOMA (1997) [+] H PYLORI PHENOTYPE AND STOMACH CANCER (1997) [+] HUMAN COLORECTAL INSTABILITOME (1998) [+] EPIDEMIOLOGY OF P16 INACTIVATION IN BARRETTS ESOPHAGUS (1998) [+] Gene Methylation and Therapeutic Response in Lung Cancer (2001) [+] DNA methylation patterns as biomarker for breast cancer (2001) [+] GENETIC ABNORMALITIES EARLY ON THE PATH OF BREAST CANCER (2001) [+] METHYLATION PROFILING IN COLORECTAL CANCER (2001) [+] Genomics: Esophageal Metaplasia-Associated Malignancy (2002) [+] DNA Methylation Markers in Esophageal Adenocarcinoma (2002) [+] DNA Methylation and Ovarian Cancer (2002) [+] Molecular Alterations in Lobular/Ductal Breast Cancer (2002) [+] DNA Methylation Markers in Ovarian Cancer (2002) [+] Tumor Markers and Recurrent Adenomas: A Follow-up Study (2002) [+] Biomarkers in Barrett's Tumorigenesis (2003) [+] Biomarkers to Assess Selenium Chemoprevention for NSCLC (2003) [+] Specific Biomarkers in Bladder Cancer Prevention (2003) [+] Screening for Breast Cancer Using Molecular Signatures (2003) [+] Molecular Characterization of Breast Basal-like Tumors (2003) [+] Genomic Analysis of ER Negative Breast Cancer (2003) [+] METHYLATION PROFILING AND RISK OF COLORECTAL CANCER (2003) [+] Patterns of Somatic Gene Alterations in Oral Cancer (2004) [+] Prevalence and Progression of Monoclonal Gammopathies (2004) [+] Methylated Genes as Serum Biomarkers for Lung Cancer (2004) [+] Biomarkers for the Progression of Head and Neck Squamous Cell Carcinoma (2006) [+] Development of DNA Methylation Markers for Early Detection of Lung Cancer (2006) [+] APC mutation and breast cancer: Prevention by curcumin (2006) [+] Pathogenesis of Ovarian Serous Borderline Tumors (2007) [+] Genomic and Functional Analysis of Oral Cancer Development (2007) [+] DNA Methylation Changes During Development and Progression of Lung Adenocarcinoma (2007) [+] Pathogenetics of a Clinically-favorable Prostate Cancer Subtype (2008) [+] Epigentic Alterations in Pre-malignant Tissue of the Bladder (2008) [+] Biomarkers for Esophageal Cancer Progression and Prognosis (2008) [+] Amplicons in Oral Dysplasia (2008) [+] Global genetic and epigenetic approaches to progression of PCa (2009) [+] Interaction of germline and somatic changes in PCa progression (2009) [+] microRNA expression profiling of benign breast tissue and breast cancer risk (2010) [+] The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer (2011) [+] Integrative epigenomic/genomic profiling and biomarker discovery in HPV+ and HPV- (2011) [+] Redefining Langerhans Cell Histiocytosis as a Myeloid Dysplasia and Identifying B (2011) [+] miRNA and colorectal cancer: associations with tumor phenotype and survival (2012) [+] Onset and biomarkers for progression of monoclonal gammopathies (2012) [+] Urinary matrix metalloproteinases and breast cancer risk in a prospective cohort (2012) [+] (PQA1) Aspirin and Inflammation: Mutations, Genes, Pathways and Prevention (2013) [+] Microbiomes in Human Pancreatic Cancer (2013) [+] Prospective Study of Human Oral Microbiome and Pancreatic Cancer Risk (2014) [+] Molecular Discriminators in Benign Breast Tissue for Future Risk of ER positive a (2014) [+] Serrated Colorectal Cancer: An Emerging Disease Subtype (2015) [+] Extent and Significance of Bacterial DNA Integrations in the Human Cancer Genome (2015) [+] An integrative approach to identify causal epigenetic markers for breast cancer (2015) [+] Foregut Microbiome and Risk of Gastric Intestinal Metaplasia, and Gastric Cancer Risk (2016) [+] (PQ1) Characterization of Premalignant Fields in a Murine Model of Head and Neck and Esophageal Cancers (2016) [+] Genomics and Mechanisms of Esophageal Carcinogenesis (2016) [+] Bacterial correlates of colorectal cancer subgroups and survival (2018) [+]
	L1D371 (1.4)	L1T17 (37%): aml (5%), leukemia (4%), acute_myeloid_leukemia_aml (4%) L1T131 (4%): self-renewal (14%), stem_cells (9%) L1T99 (4%): targeted_therapies (7%), targeted_therapy (6%) L1T49 (4%): drives (4%), mouse_models (3%), drive (3%), recapitulate (3%), therapeutic_targets (3%) L1T50 (4%): primary (3%), our (2%), still (2%), context (1%)	LOSS OF NEGATIVE SIGNALING BY THE GCSFR IN AML (1999) [+] Molecular Studies of Severe Congenital Neutropenia (2001) [+] Functional Characterization of MLL Gene Fusions (2002) [+] Cellular and Molecular Studies of Leukemic Stem Cellss (2002) [+] Molecular Analysis of Del(9q) Acute Myeloid Leukemia (2006) [+] Loss of FLJ13639 Expression in Acute Leukemia (2006) [+] Distinct acute myeloid leukemia subclasses with CEBPA mutations (2007) [+] Identifying genetic mechanisms in T-ALL with an inducible Sleeping Beauty system (2008) [+] Isolation and small molecule targeting of Ewing's Sarcoma stem cells (2008) [+] Fanconi Anemia stem cells allow molecular characterization of acute leukemia (2008) [+] CLONAL DOMINANCE OF HEMATOPOIETIC STEM CELLS EXPRESSING MUTANT CSF3R (2009) [+] Targeting PML for leukemia therapy. (2010) [+] The Role of the APC Tumor Suppressor Gene in Hematopoiesis and Leukemogenesis (2010) [+] Development of Inhibitors of the Leukemia Fusion Protein CBFbeta-SMMHC (2010) [+] Discovering chemical tools for acute myelogenous leukemia (2010) [+] Novel Biologically Targeted Therapy Against the Mer and Axl Receptor Tyrosine Kin (2010) [+] The role of microRNAs in leukemic initiation and maintenance (2011) [+] Regulation of hematopoietic stem cell and progenitor cell proliferation by Runx1 (2011) [+] Pre-BCR and STAT5 Signaling in Acute Lymphoblastic Leukemia (2011) [+] Molecular and Cellular Mechanisms of Chronic Myelomonocytic Leukemia (CMML) (2011) [+] Transponson-based screens for genes involved in acute lymphoblastic Leukemia (2011) [+] Infectious origins of childhood leukemia (2011) [+] MicroRNA in Acute Myeloid Leukemia (2011) [+] DNMT3A MUTATIONS IN ACUTE MYELOID LEUKEMIA (2011) [+] Discovery of New Targets and Pathways for T-ALL Therapy (2012) [+] Role of PGDH in leukemia pathogenesis (2012) [+] Targeting non-classical oncogenes as therapy for T-ALL (2012) [+] Oncogene Cooperativity in Leukemia Stem Cells (2012) [+] Erythropoietin and Breast Cancer Stem Cells (2012) [+] CHARACTERIZATION AND TARGETED THERAPY OF T-ALL DEFICIENT FOR PTEN AND INK4A/ARF (2012) [+] DISCOVERY OF SMALL MOLECULAR ACTIVATORS OF NR4A ORPHAN NUCLEAR RECEPTORS (2012) [+] Targeted Elimination of Cancer Stem Cells for AML Therapy (2013) [+] Role of TET2 mutations in malignant transformation and acute myeloid leukemia (2013) [+] Targeting the MLL-WDR5 protein-protein interaction (2013) [+] Cellular and molecular basis of microRNA-29a Induced Acute Myeloid Leukemia (2013) [+] Polysomy 21 in Acute Lymphoblastic Leukemia (2013) [+] Role of a Novel Homeobox Transcription Factor (HLX) in Acute Myeloid Leukemia (2013) [+] Targeted Therapy for AML Stem Cells (2013) [+] Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia (2013) [+] Targeting BCL6 in tyrosine kinase-driven leukemia (2013) [+] Aging-associated alterations in adaptive landscapes and the evolution of leukemia (2013) [+] Novel Targeted Therapy for AML (2013) [+] Genetic Dissection of Acute Myeloid Leukemia. (2014) [+] HDAC8 Mediated Regulation of Acute Myeloid Leukemia Pathogenesis and Maintenance (2014) [+] Targeting the G-CSF/STAT3 signaling pathway in neuroblastoma cancer stem cells (2014) [+] Role of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignancies (2014) [+] A Mouse Model of DNMT3A-Associated Hematologic Malignancy (2014) [+] Function of the PR domain of the MDSI-EVI1 in MLL fusion protein leukemogenesis (2014) [+] Pathogenetic Mechanism and Clinical Targeting of CSF3R-Driven Cancer (2014) [+] Metabolic pathways in leukemia (2015) [+] Direct coregulation of Notch1 by Zmiz1 in T-cell leukemia (2015) [+] Characterizing MSI2 in leukemia (2015) [+] Discovery and Development of a Selective pan-FLT3-ITD Kinase Inhibitor Clinical Candidate for the Treatment of FLT3-ITD-Driven AML (2015) [+] Molecular understanding of cytokine-Ras signals in leukemic bone marrow (2015) [+] CSF2 receptor mediated actions in t(8;21) leukemia (2015) [+] Targeting Chk1 in Acute Myeloid Leukemia (2015) [+] Molecular mechanisms of myeloid suppressor genes on chromosome 5 (2015) [+] CHARACTERIZATION OF THE MOLECULAR INTERPLAY BETWEEN HOXA9 AND OGT IN ACUTE LEUKEMIA (2015) [+] The genomic pathogenesis of Follicular Lymphoma (2015) [+] Assay Development for NSD1 Methyltransferase Inhibitor Discovery (2015) [+] (PQ5) Mitochondria in Leukemic Stem Cell Disease Progression (2016) [+] Personalized therapy for AML patients with a newly identified genetic alteration (2016) [+] Biologic and Therapeutic Significance of miR-155 in AML (2016) [+] A rapid spontaneous murine model of CN-AML (2016) [+] Aberrant signaling in acute myeloid leukemia (2016) [+] Origins of BRAF-mutant hematologic malignancies and their therapeutic resistance (2016) [+] Characterization and targeting of leukemia stem cell metabolism (2016) [+] Targeting CRLF2 and Ikaros Alterations to Reduce Health Disparities in Childhood Leukemia (2016) [+] Targeting CK2 oncogenic pathway to overcome drug resistance in high-risk leukemia (2017) [+] Cohesin Mutations in Acute Myelogenous Leukemia (2017) [+] The role and mechanism of FTO in leukemogenesis and drug response (2017) [+] Oncogenic pathways and therapeutic targets in T cell acute lymphoblastic leukemia (2017) [+] Molecular characterization and targeting of NT5C2 mutations in acute lymphoblastic leukemia (2017) [+] Mechanisms of KLF4 suppression in pediatric leukemia (2017) [+] The cohesin complex as a tumor suppressor in myeloid leukemia (2017) [+] Targeting TET1 signaling to treat acute myeloid leukemia (2017) [+] Characterization of the Role of ADAR1 in Oncogenic Transformation of Progenitors (2017) [+] Targeting microRNAs to eradicate leukemia stem cells (2017) [+] In Vivo Functional Analysis of Chromosome 7q22 Deletions in Myeloid Malignancies (2017) [+] Mechanisms of Formation and Progression of Preleukemic Stem Cells (2017) [+] Integration of epigenetic and non-coding RNA mechanisms in leukemia (2018) [+] Structure and function of genome plasticity in human cancer (2018) [+] Targeting NAMPT in Acute Myeloid Leukemia (2018) [+] MLL Family Histone Methyltransferases in Myeloid Leukemia (2018) [+] Identification and targeting of pathways separating healthy stem cell aging from malignant transformation (2018) [+] Targeting blastic plasmacytoid dendritic cell neoplasm (BPDCN) (2018) [+] KDM5 histone lysine demethylases as potential novel myeloid tumor suppressors (2018) [+] Multispecific targeting incorporating cytokine receptor pathways in high risk pediatric acute leukemias to improve durability of adoptive cell therapy-induced remissions (2018) [+] Targeting the menin-MLL1 complex for new therapeutics (2018) [+] Understanding Ikaros molecular functions for targeted therapies of pre-B ALL (2018) [+] The pathogenesis of chromosome 7q deletions in juvenile myelomonocytic leukemia (2018) [+] The phosphatase PRL3 as a MYC target and pro-survival oncogene in Acute Lymphoblastic Leukemia (2018) [+] Enhancer Dysregulation in AML (2019) [+] Targeted Small Molecule Inhibitors for Inv(16) Leukemia (2019) [+] Developing and credentialing patient-derived xenograft models to advance therapeutic approaches for chronic myelomonocytic leukemia (2019) [+] MYC activation in tumor progression of neuroblastoma (2019) [+] The role of glutaminolysis as a therapeutic target in T-ALL (2019) [+] Targetable epigenetic mechanism driving Cutaneous T cell Lymphoma (2019) [+] PPM1D in Clonal Hematopoiesis and Malignancies (2019) [+] The role and mechanism of METTL3/METTL14-mediated RNA modification in the pathogenesis and drug-resistance of AML (2019) [+] The histone demethylase JMJD1C in human Acute Myeloid Leukemia (2019) [+] Pre-BCR and STAT5 Signaling in Acute Lymphoblastic Leukemia (2019) [+] A collaborative approach to analyze and target the EWS-FLI1 transcription factor in patients with Ewing sarcoma (2019) [+] Clonal Hematopoiesis, Aging and Genome Stability in PPM1D Mutants (2019) [+]
	L1D292 (1.4)	L1T178 (16%): relapse (6%), minimal_residual_disease_mrd (3%), relapsed (3%), clinical_outcome (3%) L1T58 (8%): at_diagnosis (4%), overall_survival (4%), newly_diagnosed (4%), calgb (3%), patients_who (2%) L1T17 (7%): aml (6%), acute_myeloid_leukemia_aml (5%), leukemia (4%), bone_marrow (3%) L1T93 (6%): trials (5%), clinical_trials (5%), clinical_trial (4%), regimens (4%), patients_enrolled (3%) L1T129 (5%): markers (9%), samples_from (7%), prognostic (6%) L1T136 (5%): patients_with (25%), patients (24%), outcome (17%) L1T149 (4%): lymphoma (6%), dlbcl (6%), cll (5%), diffuse_large_b-cell_lymphoma (4%), lymphomas (4%)	CLINICAL APPLICATIONS/FLOW CYTOMETRY IN HEAD/NECK CANCER (1986) [+] MINIMAL RESIDUAL DISEASE IN LYMPHOBLASTIC LEUKEMIA (1986) [+] MINIMAL RESIDUAL DISEASE IN LYMPHOMAS WITH THE T-14-18 (1989) [+] MECHANISMS OF DRUG RESISTANCE IN ACUTE MYELOID LEUKEMIA (1990) [+] IMMUNOGLOBULIN GENE ARRANGEMENT/EXPRESSION IN LEUKEMIA (1991) [+] MULTIMODALITY TREATMENT &CLINICAL-BIOLOGICAL CORRELATES (1991) [+] CORRELATES AND TREATMENT OF PANCREATIC CARCINOMA (1991) [+] STRATEGIES FOR TREATMENT OF ACUTE PROMYELCOYTIC LEUKEMI (1992) [+] NOVEL COMBINATION THERAPY OF STAGE IV NEUROBLASTOMA (1993) [+] MINIMAL DISEASE AND OUTCOME OF TRANSPLANTS FOR LYMPHOMA (1993) [+] MONITORING THERAPY OF LOW-GRADE LYMPHOMA BY PCR (1993) [+] PHASE I STUDIES FOR PATIENTS WITH BREAST CANCER (1994) [+] CYCLOSPORINE ENHANCEMENT OF PACLITAXEL IN LUNG CANCER (1996) [+] MVAC IN BLADDER CANCER BASED ON P53 STATUS (1997) [+] RANDOMIZED ADJUVANT THERAPY OF HEAD AND NECK CANCER (1998) [+] THERAPY-RELATED LEUKEMIA--CLINICAL/BIOLOGIC PREDICTORS (1998) [+] MOLECULAR MECHANISMS OF ANTIMICROTUBULE AGENTS (1999) [+] TEL/AML1 FUSION IN PEDIATRIC ALL (1999) [+] TREATMENT RESPONSE MARKERS IN ADVANCED LARYNGEAL CANCER (1999) [+] MOLECULAR MARKERS OF PROGNOSIS IN COLON CANCER (2000) [+] BIOMARKERS OF TREATMENT RELATED LEUKEMIA (2000) [+] RESIDUAL DISEASE DETECTION IN ALL USING FLOW CYTOMETRY (2000) [+] MONITORING OF RESIDUAL DISEASE IN PEDIATRIC ALL (2000) [+] Genomic Markers of Colon Cancer Progression (2001) [+] Cystathionine B Synthase and ARA C Therapy for Leukemia (2001) [+] Genomic Profiling of Childhood de novo and Relapsed AML (2001) [+] CCNU in NSCLC Patients with Methylation of the MGMT Gene (2001) [+] ROLE OF IGF SIGNALING UPON EWINGS SARCOMA PATIENT (2001) [+] Molecular Approach in Predicting 5 Fluorouracil Efficacy (2001) [+] Significance of Genetic Alterations in Neuroblastoma (2002) [+] DNA methylation as a diagnostic marker in AML (2002) [+] B-CLL Biology: Impact of Combination Therapy (2002) [+] Adult Hodgkin's Disease and Epstein Barr Virus (2002) [+] Prognostic Markers in Trials for Head and Neck Cancer (2003) [+] Correlative Studies of erbB-2/HER2 and p53 in CALGB Pro. (2003) [+] Molecular Epidemiology of Esophageal Cancer Prognosis (2004) [+] Microarray Analysis of Responsiveness of CTCL IL-12 (2004) [+] Determinants of Response to ZD1839 (2004) [+] Molecular Mechanisms in Gastrointestinal Stromal Tumor (2004) [+] Arsenic Trioxide in Primary Curative APL Therapy (2004) [+] Molecular &Genetic Determinants of Outcome in Breast Ca (2004) [+] Blood Test Detects Change from HER2- to+in Breast Cancer (2005) [+] Preoperative chemotherapy for breast cancer (2005) [+] GENETIC PREDICTORS OF LEUKEMIA THERAPY RESPONSE (2005) [+] Lung Cancer Chemoradiation: Predictors of Survival (2005) [+] Molecular Studies of Down Syndrome Leukemia (2005) [+] EGFR Mutations in non-Small Cell Lung Cancer (2005) [+] Biology/prognostic implications of Flt3 mutations in AML (2005) [+] Predicting Melanoma Response to BAY 43-9006/Chemotherapy (2005) [+] Clinical Significance of Residual Myeloid Leukemia (2006) [+] Gene expression profiling vs MRD assessment in Myeloma (2006) [+] Biochemical markers of bone turnover in metastatic prostate cancer (2006) [+] Impact of Chemo-Immunotherapy in Relapsed/Refactory B-CLL (2006) [+] Targeted therapy in ex vivo medulloblastoma/PNET (2006) [+] Randomized study of combined epigenetic therapy (2007) [+] Molecular Basis Of Renal Cell Carcinoma Response to SU11428 (2007) [+] Prognostic Models in Diffuse Large B-Cell Lymphoma (2007) [+] Signal transduction inhibitor therapy for Lymphoma (2007) [+] Identification of Biomarkers for Early Detection of Renal Cell Carcinoma (2008) [+] Incorporating FLT3 inhibitors into AML treatment regimens (2008) [+] Predictive Markers in Metastatic Renal Cancer (2008) [+] Predictive Biomarkers of Adjuvant Trastuzumab in the HER2+N9831 Intergroup Trial (2008) [+] Pharmacogenomics of cytosine arabinoside (Ara-C) and acute myelogenous leukemia (2008) [+] Expression profiling of renal cell carcinoma utilizing tissue from CALGB 90206 (2008) [+] Proteomic analysis of api2-MALT1 positive gastric MALT lymphoma (2009) [+] Molecular targets in diffuse large B cell lymphoma (2009) [+] HDAC Inhibitors and CTCL (2009) [+] Genotype and phenotype predictors in therapy response in renal cell carcinoma (2009) [+] Drug Resistant Pathways in Relapsed Acute Lymphoblastic Leukemia(ALL) (2010) [+] Genome-Wide Predictors of Treatment-Related Toxicities (2011) [+] VEGF Gene Amplification/Haplotype as Biomarkers for Bevacizumab in Breast Cancer (2011) [+] Models to predict prognosis and benefit from adjuvant therapy in renal cell carci (2011) [+] Sapacitabine therapy to create synthetic lethality in DNA repair-deficient CLL (2012) [+] Discovery and Optimization of AML Prognostic Biomarkers (2012) [+] The Genetics of Post-Transplant Relapse in Myeloid Malignancy (2013) [+] Targeted Therapy for Lymphoid Malignancies (2013) [+] CHEK1 and WEE1 Inhibition as Therapeutic Strategies in AML (2013) [+] Identifying Cell Stress Proteins that Predict Clinical Response in Pediatric AML (2013) [+] Inhibition of Hedgehog Signaling in Gli-1+Adeno CA of the Esoph or GE junction (2013) [+] Optimizing 131I-mIBG Therapy for Children with Advanced Neuroblastoma (2013) [+] Pharmacokinetics and pharmacogenomics for 13-cis retinoic acid in neuroblastoma (2013) [+] An Epigenetic Strategy for Restoring Carboplatin Sensitivity in Ovarian Cancer (2014) [+] (PQD5) Avatar-directed Treatment for Ovarian Cancer (2014) [+] Protein-coding and non-coding RNA biomarkers for early detection of CLL (2014) [+] Molecular Evaluation of Targeted Therapies in Lymphoid Malignancies (2014) [+] Molecular Diagnostics for Risk Stratification and Monitoring of Neuroblastoma (2014) [+] Deep sequencing for minimal residual disease detection in Acute Lymphoblastic Leu (2014) [+] Predicting Clinical Outcome After Traditional and Ibrutinib-based Therapy In Chronic Lymphocytic Leukemia (2015) [+] Pharmacogenomics of Microtubule Targeting Agents (2015) [+] Monitoring disease progression in follicular lymphoma with next-gen sequencing (2015) [+] MYC as a Biomarker in Aggressive Non-Hodgkin Lymphoma (2015) [+] The identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma (2015) [+] Improving BTK Directed Therapy for CLL (2015) [+] Improving risk allocation and developing novel therapies for children with T-ALL (2015) [+] Novel Biomarkers to Risk-Stratify AML Patients with NPM1^Pos/FLT3-IT^Neg Genotype (2016) [+] Genetic Predictors of Early Clinical Failure in Diffuse Large B Cell Lymphoma (2017) [+] Mechanisms mediating resistance to ibrutinib in Non-Hodgkin's lymphoma (2017) [+] APPLYING ERROR-CORRECTED SEQUENCING TO DETECT MINIMAL RESIDUAL IN THE AAML 1031 STUDY (2017) [+] Epigenomic markers of circulating cell-free DNA and treatment outcome in multiple myeloma (2018) [+] Advancing biological and clinical applications of genomic Minimal Residual Disease detection in AML (2018) [+] DNA Methylation Inhibitor Therapy for Testicular Cancer (2018) [+] Tumor and host markers of clinical outcomes after MIBG therapy in neuroblastoma (2018) [+] Evolution and clinical impact of clonal hematopoiesis of indeterminate potential in breast tumor microenvironment (2019) [+] Targeting apoptosis in high-risk AML and MDS with BCL-2 inhibitor Venetoclax and optimized 10-day Decitabine regimen (2019) [+] A Genomic Framework for Molecular Risk Prediction & Individualized Lymphoma Therapy (2019) [+] Genetic and Epigenetic Biomarkers for B-cell Lymphoma (2019) [+] Optimizing HER2-targeting using RNA- and DNA-based predictive algorithms (2019) [+]
	L1D270 (1.4)	L1T91 (31%): glioma (6%), brain_tumors (5%), brain (5%), gbm (4%), gliomas (4%) L1T139 (4%): gene_therapy (6%), gene_delivery (5%), adenovirus (5%), oncolytic (4%), systemically_delivered (3%) L1T13 (4%): without_damaging (3%), drug_delivery (3%), delivery_vehicles (2%), enb-trail (2%), engrafts (2%) L1T42 (3%): engineered (13%) L1T55 (3%): migration (7%), invasive_behavior (5%), upar (4%), proteases (4%), cell_invasion (4%) L1T194 (3%): therapy (13%), therapeutic (8%), treat (7%), chemotherapy (6%) L1T107 (3%): efficacy (13%), effective (11%), strategies (7%)	EXPERIMENTAL CNS TUMORS: PATHOGENESIS AND TREATMENT (1985) [+] RADIOBIOLOGY OF METASTASIS CONTROL (1985) [+] OXYGEN RADICALS, NEUROTRANSMITTERS AND NEURAL TUMORS (1989) [+] THERAPY &MIGRATION OF HUMAN MALIGNANT ASTROCYTOMAS (1990) [+] EFFECT OF ANTIMICROTUBULE AGENTS ON GLIOBLASTOMA (1992) [+] NOVEL TREATMENT OF BRAIN TUMORS (1997) [+] PHASE II STUDY FOR TREATMENT OF PEDIATRIC BRAIN TUMORS (1997) [+] TUMOR SPECIFIC TARGET FOR THERAPEUTIC DELIVERIES (1998) [+] UB-PROTEOLYSIS OF ALKYLTRANSFERASE IN GLIOMA THERAPY (1998) [+] MULTIPLE GENE CARRIER ADENOVIRAL CONSTRUCTS FOR GLIOMAS (1999) [+] TAXOL BRAIN DELIVERY (1999) [+] MECHANISM OF INDUCTION OF MALIGNANT GLIOMAS (2000) [+] Transduction of Tumor Suppressor Proteins into Gliomas (2001) [+] Pancreatic Cancer Treatment Using Surgery &Gene Therapy (2002) [+] Cell Type-Specific Viral Translation in the CNS (2002) [+] Suppression of glioma invasion by a bicistronic constuct (2003) [+] Role of TFPI-2 in human gliomas invasiveness (2003) [+] Use of Beta-Lapachone for Lung Cancer Chemotherapy (2003) [+] Influence of P-glycoprotein in treating brain tumors (2004) [+] Imaging Signaling Changes in Cancer and Treatment (2004) [+] Targeting Glioma by Anti-MMPs-2 and -9 DNAzymes (2005) [+] Cath B and muPAR siRNA constructs regressed glioma growth (2005) [+] Imaging of gene expression in glioblastoma (2006) [+] Efficacy and toxicity of TRAIL against gliomas (2006) [+] Bone Marrow Stem Cells: Novel Treatment of Human Glioma (2006) [+] Lactate Transport as a Therapeutic Target in Glioma (2006) [+] Transgenic in vivo delivery of MDA7/IL24 for maligannt glioma therapy (2008) [+] Polynuclear Platinums in Targeted and Combination Glioma Therapy (2008) [+] Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation (2009) [+] Improving Delivery of Molecularly-Targeted Therapy to Invasive Glioma Cells (2010) [+] Developing diagnostic and therapeutic stem cells for cancer therapy (2010) [+] Multimodality approach to hepatic colorectal metastases (2010) [+] Engineered HGF-NK1 antagonists for Met-targeted cancer imaging and therapy (2010) [+] Acidic Phospholipid-Selective Treatment for Neuroblastoma (2011) [+] Cdk4/6 Inhibitor Therapy for Glioblastoma Multiforme (2012) [+] MicroRNA Therapy for Lymph Node Metastatic Breast Cancer (2012) [+] Modeling and microsystems approach to glioma invasion (2013) [+] Molecular Target Variation Across Environments and at Margins of Glioblastoma (2013) [+] Targeting Ferritin in Glioblastoma (2013) [+] In vivo imaging of encapsulated stem cells in mouse models of tumor resection (2013) [+] Prevention and treatment of brain micrometastases of breast cancer (2013) [+] Indirubins: novel anti-invasive and anti-angiogenic drugs for malignant gliomas (2013) [+] BMP4 Engineered Mesenchymal Stem Cell Therapy for Glioblastoma (2015) [+] Therapeutically Exploiting a Newly Isolated Neural-like Stem Cell Against GBM (2015) [+] Nanoparticle modified Human Fat Derived Mesenchymal Stem Cells for Brain Cancer (2016) [+] In vivo imaging of Stem cell loaded oncolytic viruses for cancer therapy (2016) [+] Targeted Delivery of Brain Penetrating DNA Nanoparticles to Brain Tumors (2016) [+] Fate and efficacy of targeted therapies for metastatic tumors (2016) [+] Systemic RNA interference to reactivate p53 tumor suppression (2017) [+] MSC-Derived Exosomes and MicroRNA in Glioma Therapy (2018) [+] Fluorinated macrocyclic peptides as BBB penetrating agent for improved GBM treatment (2019) [+] Modeling BRAF-fusion driven pediatric brain tumors in the mouse (2019) [+] Characterization of Onalespib, A novel long acting Hsp90 inhibitor, as a chemo and radiosensitizer in Adults with Newly Diagnosed Glioblastoma (2019) [+]
	L1D376 (1.3)	L1T92 (15%): p53 (8%), tumor_suppressor_p53 (6%) L1T50 (8%): cancer (3%), our (1%), many (1%), has (1%), test (1%) L1T26 (7%): degradation (6%), ubiquitination (4%), cullin (3%), skp2 (3%) L1T168 (6%): tumorigenesis (14%), tumor_suppressor (11%) L1T48 (5%): human_cancers (8%), functions (5%) L1T49 (5%): mechanistically (4%), mouse_models (4%), our_proposed_studies (4%), we_discovered (3%), oncogenic_mutations (3%) L1T137 (4%): restoring (7%), promotes (6%), impairs (4%), prevents (4%), suppressing (4%)	Mdm2 in Lymphoma Development (2003) [+] Validation of a New Target for Prostate Cancer Therapy (2004) [+] Role and therapeutical potential of Cdk4/6 in B-lymphoma (2006) [+] p53-Independent Pathways in Mdm2-Mediated Transformation (2007) [+] Cooperation of oncogenic mutations in the control of malignancy (2007) [+] Rac GTPases as Targets in Lymphomagenesis (2007) [+] INTEGRATION OF ONCOGENIC SIGNALS BY THE NUCLEOLAR ARF-NPM NETWORK (2008) [+] Chemoresistance and Motility: Role of Mutant p53 and NF-kB2 in Cancer (2008) [+] Role of Autophagy in Cancer (2008) [+] Genetic pathways of replicative senescence and its function in tumorigenesis (2009) [+] Characterization and drug targeting of the PML tumor suppressor in lung cancer (2009) [+] The role of deregulated protein synthesis control in Myc-induced tumorigenesis (2009) [+] Role of UVRAG-mediated Autophagy in Tumor Suppression (2009) [+] The contribution of protein translation to tumorigenesis (2010) [+] The Role of Cul4A in Genome Stability and Cancer Development (2010) [+] Mechanisms and Treatment of PTEN Mutant Prostate Tumorigenesis (2010) [+] Molecular interactions and restoration strategies of PTEN and p53 in gliomas (2010) [+] Targeting the MYC Oncogene with CDK Inhibitors (2010) [+] Coordinately regulated alternative splicing in DNA damage and cancer (2010) [+] The Study of the Circadian Rhythm in p53 Signaling (2010) [+] Regulation of Myc-Mediated Tumorigenesis (2011) [+] THE ROLE OF NEDD4-1 IN IGF-1R SIGNALING (2011) [+] Alternative Mechanisms to Inactivate p53 During Oncogenesis (2011) [+] Tumorigenic Role of the CUL4A Ubiquitin Ligase (2011) [+] Dual Targeting of the p53 pathway for development of anti-cancer therapy (2012) [+] Role of PTEN in Chromosome Segregation and its Importance for Tumor Suppression (2012) [+] Molecular mechanisms of B cell malignant transformation (2012) [+] The role of senescent cells in late-life tumorigenesis (2013) [+] Angiogenin-induced RNA cleavage in cancer (2013) [+] Novel regulation of PI3K/Akt to direct targeted breast cancer therapies (2013) [+] PDLIM2 as a cancer and chemosensitizing target (2013) [+] Cell Fate Control by Integrated E2F, FoxO and PI3K Signaling in Retinoblastoma (2013) [+] Targeting stabilized mutant p53 protein (2013) [+] The role of MDM2-MTBP axis in cancer metastasis (2014) [+] Stabilizing nuclear p27kip1 as a therapeutic target for endometrial cancer (2014) [+] elF4E-Dependent Translation Control in the Oncogenic Stress Response and Cancer (2014) [+] P53 survival target DDR1 kinase in DNA damage response and carcinogenesis (2015) [+] p53-Mediated Tumor Immune Surveillance (2015) [+] The role of the LZTR1 ubiquitin ligase in stem cells and cancer (2015) [+] Ceramide signaling in the regulation of cellular response to folate stress (2015) [+] Dissecting Skp2 functions in pRb and p53 doubly deficient tumorigenesis (2016) [+] Development of Zinc Metallochaperones as Mutant p53 Targeted Anti-cancer Drugs (2016) [+] Understanding the role of ?B-Ras proteins in tumorigenesis (2016) [+] Targeting the APC/Cdc20 E3 ubiquitin ligase for chemoradiation sensitization (2016) [+] Studies on thymidylate synthase as a tumor-promoting oncogene for development of new allosteric inhibitors for cancer treatment (2016) [+] Control of Protein Synthesis by the UPS Under Stress (2016) [+] REGULATION OF TUMOR SUPPRESSION BY ARF (2016) [+] p53 Variants in Cancer Risk and Therapy (2016) [+] Targeting interplay between KLF4 and PRMT5 in carcinogenesis (2016) [+] CDK2 and Cancer: Mechanisms and Opportunities (2016) [+] Induction of Tumor Cell Dormancy by Ribosomal Intergenic Spacer Noncoding RNA (2016) [+] Regulation of non-proteolytic ubiquitination in cancer chemoresistance and progression (2017) [+] Targeted inhibition of ribosomal RNA synthesis in LKB1-deficient cancers (2017) [+] The role of chronic stress in regulation of mutant p53 and tumorigenesis (2017) [+] Novel therapeutics for targeting checkpoint dysfunction in cancer (2017) [+] Role of Senescent Cells in Radiation-induced Pulmonary Fibrosis (2017) [+] Understanding Spatially Regulated Tumor-Inhibitory Function of Profilin-1 and its Deregulation in Breast Cancer (2017) [+] Deconstructing the multi-faceted roles of Rb in tumor progression (2018) [+] New Vulnerabilities in MYC-Driven Breast Cancer (2018) [+] Tumor suppression, p53 and retrotransposons (2018) [+] Activating p53 for colorectal cancer prevention (2018) [+] Control of mutant p53 stability via the mevalonate pathway-DNAJA1 axis (2018) [+] G3BP1 Suppresses SPOP Ubiquitin Ligase to Promote Prostate Tumorigenesis (2018) [+] Employing CRISPR inactivation screening and in vivo models towards improving treatments for SCLC (2019) [+] Vulnerability of SCLC based on bi-allelic genetic inactivation of RB1 and TP53 (2019) [+]
	L1D328 (1.3)	L1T152 (28%): ovarian_cancer (7%), ovarian (7%), ovary (4%) L1T44 (7%): prostate_cancer (12%), prostate (9%), prostate_cancers (8%) L1T129 (4%): prognostic (6%), specimens_from (5%), specimens (5%), gene_expression_profiling (4%), markers (4%) L1T144 (4%): metastatic (12%), metastasis (11%), metastases (7%), metastatic_disease (7%) L1T165 (3%): carcinoma (9%), epithelium (6%), epithelial (6%), invasive_carcinoma (6%), epithelial_cells (6%) L1T113 (3%): men (17%) L1T29 (3%): chromosome (4%), 8q (3%), mutational_events (3%), on_chromosome (3%), tsg (2%)	MOLECULAR MECHANISMS FOR PROSTATE CANCER CELL GROWTH (1990) [+] HER-2 NEU PROTO-ONCOGENE IN OVARIAN &ENDOMETRIAL CANCER (1991) [+] TRUNCATED C-ERBB RECEPTORS IN WOMEN WITH OVARIAN CANCER (1992) [+] MOLECULAR PATHWAY TO PROSTATE CANCER (1992) [+] GROWTH REGULATION &TRANSFORMATION OF OVARIAN EPITHELIUM (1992) [+] ANTIONCOGENES IN CARCINOGEN-INDUCED PANCREATIC CANCER (1993) [+] MOUSE MODELS OF OVARIAN TUMOR DEVELOPMENT (1993) [+] OVARIAN CARCINOMA--ROLE OF LAMININ AND ITS RECEPTORS (1993) [+] PATHOGENESIS OF HUMAN PROSTATE CARCINOMAS (1993) [+] GENETIC CHANGES INVOLVED IN OVARIAN CANCER INITIATION (1993) [+] MOUSE MODELS FOR PROSTATE CARCINOGENESIS (1994) [+] PROSTATE CANCER &VITAMIN D--RECEPTORS, RESPONSES &RACE (1995) [+] MECHANISMS OF METASTASIS IN EXPERIMENTAL PROSTATE CANCER (1995) [+] SIGNIFICANCE OF MICROMETASTASES IN PROSTATE CANCER (1995) [+] MOLECULAR STAGING OF PROSTATE CANCER (1996) [+] DEVELOPMENT OF MOLECULAR MARKERS FOR PROSTATE CANCER (1996) [+] HORMONE REGULATED GENE IN OVARIAN CARCINOGENESIS (1997) [+] SIGNAL TRANSDUCTION MOLECULE IN OVARIAN CARCINOGENESIS (1998) [+] Y2, A NOVEL OVARIAN CANCER TUMOR SUPPRESSOR GENE (1998) [+] NOVEL PROSTATE CANCER GENE AND MONOCLONAL ANTIBODY (1998) [+] MRI STUDIES OF ANGIOGENESIS IN OVARIAN CANCER (1998) [+] EXPRESSION OF CYCLIN E IN GYNECOLOGIC MALIGNANCIES (2000) [+] INFLAMMATION AND ATROPHY IN PROSTATE CARCINOGENESIS (2001) [+] PROSTATE CANCER METASTATIC COLONIZATION--ROLE OF MKK4 (2001) [+] Genes important in breast cancer metastasis (2001) [+] hAR Alterations and Androgen Independent Prostate Cancer (2001) [+] Modes of Prostate Ca Progression--role of p53 Pathway (2001) [+] Acrogranin Function in the Ovary (2002) [+] Regulation of CSF-1 in Ovarian Cancer (2002) [+] Epithelial Positioning Organization and Ovarian Cancer (2002) [+] Modeling Prostate Cancer by Conditional Gene Targeting (2002) [+] Molecular biomarkers of selenium chemoprevention (2002) [+] Novel Molecular Profiling of Prostate Cancer Signatures (2002) [+] Molecular Pathogenesis of Ovarian Endometrioid Adenocarc (2002) [+] Molecular Strategies for Gastric Carcinoid Surgery (2003) [+] PTEN and the Molecular Genetics of Endometrial Cancer (2003) [+] KLF6 Gene and Clinical Correlates in Prostate Cancer (2003) [+] Diagnostic Therapeutic Targets in Prostate Cancer (2003) [+] Gonadotropins &Cox-2 in Ovarian Cancer Prevention (2003) [+] Molecular Changes Associated with PCa bone metastases (2003) [+] Tumor metastasis: Biobehavioral mechanisms (2004) [+] Defining the role of Id1 in melanoma development (2004) [+] PTEN and Prostate Cancer Progression (2004) [+] characterization of ovarian cancer in a mouse model (2004) [+] THE ROLE OF PROTEIN KINASE C IN ENDOMETRIAL CANCER (2004) [+] HOX genes in ovarian neoplasia (2004) [+] Role of Cell Mediators in Asbestos-SV40 Carcinogenesis (2005) [+] Loss of Vitamin A Metabolism in Ovarian Oncogenesis (2005) [+] Modeling ovarian carcinoma by defined genetic alterations (2005) [+] Validation of genomic targets in melanoma (2005) [+] CaP Metastasis Biomarkers: Validation/Genomics/Biology (2005) [+] Molecular analysis of metastatic prostate cancer in mice (2005) [+] CELL NON-AUTONOMOUS MODE OF TUMOR SUPPRESSION BY BRCA1 (2006) [+] Towards Understanding Prostate Cancer Heterogeneity (2007) [+] Vascular Leukocytes influence the tumor microenvironment (2007) [+] PTTG Role in Ovarian Tumorigenesis and Matastasis (2007) [+] MicroRNAs in Human Ovarian Cancer (2009) [+] Polyclonal Intestinal Tumors: Formation, Progression, and Significance (2009) [+] Alternative splicing and epithelial-mesenchymal plasticity in prostate tumors (2009) [+] Intervention models for thyroid proliferative disease using a bioactive food comp (2009) [+] Defining a Pre-Malignant Phenotype in Fallopian Tube Epithelium (2009) [+] Role of the Mullerian Tract in Ovarian Cancer Development (2009) [+] The Role of HEF1 in Ovarian Cancer Development, Progression, and Metastasis (2009) [+] Multifunctional roles of homeobox gene DLX4 in ovarian cancer (2010) [+] Novel Biomarkers in Ovarian Cancer (2010) [+] Role of the BMP SMADs in Oncogenesis (2010) [+] Novel prostate cancer oncogenes identified by transposon mutagenesis (2010) [+] Initiation and evolution of the ovarian cancer microenvironment (2011) [+] Role of Kallikrein 6 expression and secretion in colon cancer (2012) [+] Role of Transcriptional Corepressor CtBP1 in Prostate Cancer Progression (2012) [+] Estrogen Receptors in Human Prostate Stem-Progenitor Cells (2013) [+] Mechanism of PIN development in Abi1/Hssh3bp1 KO mouse (2013) [+] The FGF18/FGFR4 amplicon: Novel therapeutic biomarkers for ovarian cancer (2013) [+] Defining the temporal sequence of PI3K pathway mutations in bladder cancer (2014) [+] Steroid Hormones Regulate Ovarian Cancer Progression and Metastasis (2014) [+] PHIP as a Biomarker of Triple-Negative Melanoma (2014) [+] Origins of Ovarian Carcinoma (2015) [+] Ovarian Cancer Chemoprevention (2015) [+] Credentialing Ovarian Cancer Models in the Context of the Dualistic Pathway Paradigm (2016) [+] The Hippo/YAP Signaling Pathway in Ovarian High Grade Serous Carcinoma (2016) [+] The Germ Cell Gene TDRD1 As A Novel Prostate Cancer Biomarker (2017) [+] Vitamin D and Progestins for the Chemoprevention of Fallopian Tube/Ovarian Cancer (2018) [+] Pre-metastatic Omental Niche Formation in Ovarian Cancer (2018) [+] Ovarian Epithelial Cancer Progenitor Cell Population (2018) [+] Analysis of epithelial heterogeneity in prostate development and cancer (2019) [+] Modeling Factors Associated with Risk of High-Grade Serous Carcinoma in Mice (2019) [+] Targeting p53 conformational defects to arrest carcinogenesis (2019) [+] Systems analysis of aggressive prostate cancer pathology (2019) [+] Dynamic Interactions of the Ovarian-Fallopian Axis in High Grade Serous Ovarian Cancer (2019) [+] Prostate Cancer Health Disparity: Role of PDEF (2019) [+]